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公开(公告)号：EP2718263A1
公开(公告)日：2014-04-16
申请号：EP11827762.3
申请日：2011-09-28
发明人： ZHANG, Zhaoyong
IPC分类号： C07D211/90
CPC分类号： C07D401/12
摘要： Disclosed is a method for preparing benidipine hydrochloride, which comprising: 1) during the pre-treatment stage including acylchloridizing the main ring of dihydropyridine and then linking the side chain to synthesize directly benidipine hydrochloride, ultrasound technology is introduced, and the reactant material is dispersed and dissolved by untrasound to increase reaction rate; and/or 2) during the post-treatment stage, ultrasound technology is introduced and crude crystals or product obtained by heating to dryness of benidipine hydrochloride obtained via the method described above or any other synthetic routes is dissolved once more and then highly purified benidipine hydrochloride is obtained by untrasound.
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公开(公告)号：EP2718263B1
公开(公告)日：2016-04-20
申请号：EP11827762.3
申请日：2011-09-28
发明人： ZHANG, Zhaoyong
IPC分类号： C07D401/12
CPC分类号： C07D401/12
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公开(公告)号：EP2718263A4
公开(公告)日：2015-01-21
申请号：EP11827762
申请日：2011-09-28
发明人： ZHANG ZHAOYONG
IPC分类号： C07D401/12
CPC分类号： C07D401/12
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4.发明公开METHOD FOR PURIFICATION OF CALCIUM CHANNEL BLOCKERS OF DIHYDROPYRIDINE TYPE AND PREPARATION OF NANOPARTICLES THEREOF 审中-公开PROCEDURE FOR CLEANING二氢吡啶钙通道阻滞剂和纳米颗粒的制作THEREOF
公开(公告)号：EP2700632A4
公开(公告)日：2014-09-03
申请号：EP12773774
申请日：2012-04-14
发明人： CHEN QIONG
IPC分类号： C07D211/90 , B01D9/02 , B01J19/10 , C07C303/44 , C07C309/04
CPC分类号： C07D211/90 , B01D9/0081
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5.发明公开METHOD FOR PURIFICATION OF CALCIUM CHANNEL BLOCKERS OF DIHYDROPYRIDINE TYPE AND PREPARATION OF NANOPARTICLES THEREOF 审中-公开PROCEDURE FOR CLEANING二氢吡啶钙通道阻滞剂和纳米颗粒的制作THEREOF
公开(公告)号：EP2700632A1
公开(公告)日：2014-02-26
申请号：EP12773774.0
申请日：2012-04-14
发明人： CHEN, Qiong
IPC分类号： C07D211/90 , C07C309/04 , C07C303/44 , B01D9/02 , B01J19/10
CPC分类号： C07D211/90 , B01D9/0081
摘要： A method for purification calcium ion channel blocker medicament of dihydropyridine type and pharmaceutically acceptable salts thereof through the ultrasonic crystallization technology and direct preparation of nanoparticles thereof.
摘要翻译： 一种用于通过超声波结晶技术及其二氢吡啶类和药学上可接受的盐的纯化钙离子通道阻断剂的药物和直接制备纳米颗粒的方法，其。
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