公开(公告)号：EP3438094A1

公开(公告)日：2019-02-06

申请号：EP17773212.0

申请日：2017-03-28

申请人： Precedo Pharmaceuticals Co., Ltd. ,  Hefei Gracevo Bio-Medicine Co., Ltd

发明人： LIU, Qingsong ,  LIU, Jing ,  WANG, Qiang ,  WANG, Beilei ,  LIU, Feiyang ,  QI, Shuang ,  QI, Ziping ,  ZOU, Fengming ,  CHEN, Cheng ,  WANG, Wenchao ,  HU, Chen ,  LIU, Xiaochuan ,  WANG, Wei ,  WANG, Aoli ,  WANG, Li ,  HU, Zhenquan ,  REN, Tao

IPC分类号： C07D211/44 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D401/14 ,  C07D409/14 ,  A61K31/45 ,  A61K31/4545 ,  A61K31/454 ,  A61P35/00 ,  A61P35/02

摘要： The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof. The compound itself in the present invention or in combination with at least one therapeutic agent can be used for preventing or treating diseases, disorders or symptoms caused by the adjustment of the activity of tyrosine kinase C-KIT, or affected by the activity of the tyrosine kinase C-KIT or involving in the activity of the tyrosine kinase C-KIT, especially cancers or other cell proliferation diseases.