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公开(公告)号：EP3438094A1
公开(公告)日：2019-02-06
申请号：EP17773212.0
申请日：2017-03-28
发明人： LIU, Qingsong , LIU, Jing , WANG, Qiang , WANG, Beilei , LIU, Feiyang , QI, Shuang , QI, Ziping , ZOU, Fengming , CHEN, Cheng , WANG, Wenchao , HU, Chen , LIU, Xiaochuan , WANG, Wei , WANG, Aoli , WANG, Li , HU, Zhenquan , REN, Tao
IPC分类号： C07D211/44 , C07D401/04 , C07D413/04 , C07D413/14 , C07D401/14 , C07D409/14 , A61K31/45 , A61K31/4545 , A61K31/454 , A61P35/00 , A61P35/02
摘要： The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof. The compound itself in the present invention or in combination with at least one therapeutic agent can be used for preventing or treating diseases, disorders or symptoms caused by the adjustment of the activity of tyrosine kinase C-KIT, or affected by the activity of the tyrosine kinase C-KIT or involving in the activity of the tyrosine kinase C-KIT, especially cancers or other cell proliferation diseases.
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2.发明公开
公开(公告)号：EP4417687A1
公开(公告)日：2024-08-21
申请号：EP21960423.8
申请日：2021-11-22
发明人： LIU, Qingsong , HE, Yuying , HUANG, Tao , CHEN, Cheng
CPC分类号： Y02A50/30 , C12Q1/02 , C07D475/12 , C07D475/00 , C12N5/06
摘要： A culture medium for primary ovarian cancer cells, an in vitro culture method and an application thereof. The culture medium contains: an MST1/2 kinase inhibitor; a Rho kinase inhibitor, which is selected from at least one among Y27632, Fasudil and H-1152; an insulin-transferrin-selenium supplement; insulin; prostaglandin E2; an epidermal growth factor; gastrin; an insulin-like growth factor-1; cholera toxin; amphiregulin; N2; and B27. Compared with existing culture methods, the in vitro culture using said culture medium has higher amplification efficiency. Using the culture medium for the culturing of primary ovarian cancer cells may maintain the morphological structure and pathological features of primary tissues, and improve the success rate and survival rate of the cultured primary ovarian cancer cells.
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公开(公告)号：EP3466952A1
公开(公告)日：2019-04-10
申请号：EP17805907.7
申请日：2017-06-05
发明人： LIU, Qingsong , LIU, Jing , LI, Xixiang , WANG, Aoli , QI, Ziping , WU, Hong , WU, Jiaxin , WANG, Wenchao , HU, Chen , CHEN, Cheng , WANG, Li , WANG, Beilei
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/519 , A61P35/00 , A61P35/02 , A61P17/06 , A61P13/08
摘要： The present invention provides a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. The present invention also provides a pharmaceutical composition comprising the compound of formula (I), as well as the use and method for preventing or treating FLT3-related conditions, especially conditions related to mutant FLT3 kinase (particularly, FLT3/ITD mutant kinase).
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4.发明公开
公开(公告)号：EP4403626A1
公开(公告)日：2024-07-24
申请号：EP21957266.6
申请日：2021-10-26
发明人： LIU, Qingsong , HU, Jie , CHEN, Cheng , HUANG, Tao
摘要： A primary cell culture medium for culturing primary lung cancer epithelial cells, a culture method using the primary cell culture medium, and an application thereof in drug efficacy evaluation and screening. The culture medium contains an MST1/2 kinase inhibitor, a ROCK kinase inhibitor, a fibroblast growth factor, at least one additive selected from a B27 additive and an N2 additive, an epidermal growth factor, transferrin, gastrin, and a TGFβ type I receptor inhibitor.
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公开(公告)号：EP4286514A1
公开(公告)日：2023-12-06
申请号：EP21921968.0
申请日：2021-02-05
发明人： LIU, Qingsong , HE, Yuying , CHEN, Cheng , HUANG, Tao , REN, Tao , WANG, Wenchao , WANG, Li
摘要： Disclosed are a culture medium and a culture method for in vitro expansion of primary cells of intestinal cancer. The culture medium comprises an initial culture medium, a Rho protease inhibitor, an antibiotic, gastrin, A8301, a non-essential amino acid, cholera toxin, an insulin-like growth factor-1, nicotinamide, insulin, fetal bovine serum, and an additive selected from at least one of a B27 additive and an N2 additive. By using the culture medium, effective and rapid expansion of the primary cells of intestinal cancer can be achieved. The expanded cells maintain the pathological characteristics of patients, and the culture success rate and the cell expansion rate of the primary cells of intestinal cancer are improved, which provide a research foundation for personalized treatment of the patients.
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6.发明公开
公开(公告)号：EP4137565A1
公开(公告)日：2023-02-22
申请号：EP20930874.1
申请日：2020-04-23
发明人： LIU, Qingsong , HU, Jie , WANG, Wenchao , CHEN, Cheng , REN, Tao , WANG, Li
摘要： Provided are a primary cell culture medium that contains a combination of an MST1/2 kinase inhibitor and a ROCK kinase inhibitor and is used for culturing primary esophageal squamous cell carcinoma epithelial cells, and a culture method using the primay cell culture medium. In the culture method, the primary cell culture medium is used to culture primay cells on a culture vessel coated with an extracellular matrix glue, so that the primary cells prolilferate rapidly. A cell model obtained by using the primary cell culture medium and the primary cell culture method of the present invention can be used for the efficacy evaluation and screening of drugs.
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7.发明公开
公开(公告)号：EP4400582A1
公开(公告)日：2024-07-17
申请号：EP21956476.2
申请日：2021-09-16
发明人： LIU, Qing Song , WANG, Wen Liang , HUANG, Tao , CHEN, Cheng
摘要： A culture medium for hepatoma organoid culture, comprising an MST1/2 kinase inhibitor, at least one cell culture additive selected from N2 and B27, a hepatocyte growth factor, an ITS cell culture additive, Y27632, dexamethasone, Neuregulin-1, insulin, an epidermal cell growth factor, GlutaMAX, and non-essential amino acids. The application further relates to a hepatoma organoid culture method and an application thereof. By using the culture medium for hepatoma organoid, effective and rapid expansion of the hepatoma organoid can be achieved, and the organoid obtained by such expansion maintains the pathological characteristics of a patient, improves the culture success rate and the expansion rate of the hepatoma organoid, and provides a research basis for individualized treatment of the patient.
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公开(公告)号：EP4389875A1
公开(公告)日：2024-06-26
申请号：EP21953875.8
申请日：2021-08-31
发明人： LIU, Qing Song , HE, Yu Ying , CHEN, Cheng , HUANG, Tao , REN, Tao , WANG, Wen Chao , WANG, Li
IPC分类号： C12N5/00 , C12N5/0781
摘要： Provided are a culture medium and a culture method for human primary acute myeloid leukemia cells. The culture medium for human primary acute myeloid leukemia cells contains a glutamine additive, non-essential amino acids, human interleukin-6, human interleukin-7, human interleukin-3, recombinant human FLT3 Ligand, a recombinant human macrophage colony stimulating factor and a human stem cell factor. Acute myeloid leukemia cells can be cultured with higher amplification efficiency and longer in-vitro culture time by using the culture medium and culture method. Also provided are human primary acute myeloid leukemia cells cultured in vitro by using the culture medium, and the use thereof for curative effect evaluation and screening of drugs.
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9.发明公开
公开(公告)号：EP4368706A1
公开(公告)日：2024-05-15
申请号：EP21948946.5
申请日：2021-07-28
发明人： LIU, Qing Song , HU, Jie , HUANG, Tao , CHEN, Cheng
摘要： A primay cell culture medium for culturing primary lung cancer epithelial cells, containing an MST1/2 kinase inhibitor, a ROCK inhibitor, fibroblast growth factor 7, at least one additive of B27 additive and N2 additive, hepatocyte growth factor, insulin-like growth factor 1, interleukin 6, and a TGFβ type I receptor inhibitor. The invention also relates to a culture method using the primary cell culture medium and its application in the efficacy evaluating and screening of drugs. In the culture method, the primary cell culture medium is used to culture primay cells in a culture vessel coated with an extracellular matrix gel, to make the primary cells expend rapidly. A cell model obtained using the primary cell culture medium and the primary cell culture method can be used for the efficacy evaluating and screening of drugs.
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10.发明公开
公开(公告)号：EP4105320A1
公开(公告)日：2022-12-21
申请号：EP20918987.7
申请日：2020-02-26
发明人： LIU, Qingsong , HU, Jie , CHEN, Cheng , WANG, Wenchao , WANG, Li
IPC分类号： C12N5/09
摘要： Provided are a culture medium and cultivation method of rapidly expanding primary cells of esophageal squamous carcinoma in vitro, and the use thereof in screening drugs. The culture medium comprises an initial culture medium selected from DMEM/F12, DMEM, F12, or RPMI-1640, a Rho protease inhibitor, an antibiotic, insulin, an N2 additive, insulin-like growth factor 1, a non-essential amino acid, and optionally, hydrocortisone, optionally, glutamine, and optionally, bovine pituitary extract.
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