公开(公告)号：EP1986645A1

公开(公告)日：2008-11-05

申请号：EP07716991.0

申请日：2007-01-24

申请人： Array Biopharma, Inc. ,  Aicher, Thomas Daniel ,  BOYD, Steven Armen ,  Chicarelli, Mark Joseph ,  Condroski, Kevin Ronald ,  Hinklin, Ronald Jay ,  Singh, Ajay ,  Turner, Timothy Mark ,  Rustam, Ferdinand Garrey

发明人： AICHER, Thomas, Daniel ,  BOYD, Steven, Armen ,  CHICARELLI, Mark, Joseph ,  CONDROSKI, Kevin, Ronald ,  HINKLIN, Ronald, J. ,  SINGH, Ajay ,  TURNER, Timothy, Mark ,  RUSTAM, Ferdinand, Garrey

IPC分类号： A61K31/427 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04 ,  A61P3/10 ,  A61K31/428

CPC分类号： C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

摘要： Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase. (Formula I) wherein R2, L, Z, Y, G and R1 are as defined in the claims.

摘要翻译： 提供可用于治疗和/或预防由葡萄糖激酶活性水平不足（例如糖尿病）介导的疾病的式I化合物。 还提供治疗或预防葡萄糖激酶活性降低或可通过激活葡萄糖激酶进行治疗的疾病和病症的方法。 （式I）其中R2，L，Z，Y，G和R1如权利要求中所定义。