公开(公告)号：EP4033992A1

公开(公告)日：2022-08-03

申请号：EP20776172.7

申请日：2020-09-23

申请人： Institut Químic de Sarrià CETS Fundació Privada ,  Hospital Clinic De Barcelona

发明人： GIL, Alejandro Aranda ,  GRANADA, Andrés-Amador García ,  LÓPEZ, Jordi Martorell ,  ALONSO, Vicente Riambau

IPC分类号： A61B17/00

公开(公告)号：EP3795090A1

公开(公告)日：2021-03-24

申请号：EP19382814.2

申请日：2019-09-23

申请人： Institut Químic de Sarrià CETS Fundació Privada ,  Hospital Clinic De Barcelona

发明人： Aranda Gil, Alejandro ,  García Granada, Andrés-Amador ,  Martorell López, Jordi ,  Riambau Alonso, Vicente

IPC分类号： A61B17/00 ,  A61F2/06

摘要： The present invention provides a patch deployment device, the device comprising a pusher wire having a proximal end and a distal end; a plurality of deployment wires, wherein each deployment wire: has a first end and a second end, and the first end and the second end are connected to the distal end of the pusher wire; and is configured to be in an unexpanded state when positioned and constrained within a catheter, and configured to self-expand into an expanded state when positioned beyond a distal end of the catheter and not constrained, wherein in the expanded state at least a portion of the wire is positioned substantially within a plane that is substantially perpendicular to the longitudinal axis of the pusher wire and has an asymmetric form when viewed along a direction parallel to the longitudinal axis of the pusher wire.

公开(公告)号：EP3638814A1

公开(公告)日：2020-04-22

申请号：EP18733500.5

申请日：2018-06-05

申请人： The United States of America, as Represented by The Secretary, Department of Health and Human Services Office of Technology Transfer ,  British Columbia Cancer Agency Branch ,  Mayo Foundation for Medical Education and Research ,  Julius-Maximilians-Universitaet Wuerzburg ,  The Board of Regents of the University of Nebraska ,  Oslo University Hospital HF ,  University of Health Network ,  Hospital Clinic De Barcelona ,  Universitat de Barcelona ,  Institut D'Investigacions Biomèdiques August Pi I Sunyer - IDIBAPS ,  Robert Bosch Gesellschaft für medizinische Forschung mbH ,  Oregon Health & Science University ,  City of Hope ,  The Cleveland Clinic Foundation

发明人： STAUDT, Louis M. ,  STEIDL, Christian ,  MOTTOK, Anja ,  WRIGHT, George W. ,  SCOTT, David William ,  RIMSZA, Lisa M. ,  ROSENWALD, Andreas ,  GASCOYNE, Randy ,  GREINER, Timothy ,  WEISENBURGER, Dennis ,  SMELAND, Erlend B. ,  DELABIE, Jan ,  CAMPO GUERRI, Elias ,  OTT, German ,  BRAZIEL, Rita ,  JAFFE, Elaine S. ,  FU, Kai ,  CHAN, Wing C. ,  SONG, Joo ,  COOK, James R.

IPC分类号： C12Q1/6886

公开(公告)号：EP3180446A1

公开(公告)日：2017-06-21

申请号：EP15757005.2

申请日：2015-08-14

申请人： Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca ,  Hospital Clinic De Barcelona ,  Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol

发明人： BARRIL, Sara Marsal ,  CANO, Antonio Julià ,  DE DIOS CAÑETE CRESPILLO, Juan ,  FERRÁNDIZ FORASTER, Carles

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  A61K2039/505 ,  A61K2039/55 ,  C07K16/241 ,  C07K2317/76 ,  C12Q2600/106 ,  C12Q2600/156

摘要： The present invention provides methods for selecting an individual with psoriasis (Ps) or psoriatic arthritis (PsA) who should receive or who is likely to respond to a treatment with an anti-tumor necrosis factor alpha (anti-TNFα) therapy. In addition, provided herein are methods for selecting an individual with Ps or PsA who should receive or who is likely to respond to a therapy that is not an anti-TNFα therapy, e.g., a non-anti-TNFα therapy for the treatment of Ps or PsA. Specifically, the methods of the present invention relate to detecting the presence of distinct alleles of the PDE3A-SLCO1C1 locus which are associated with a clinical response to an anti-TNFα therapy or a non-anti-TNF therapy in patients with Ps or PsA.

摘要翻译： 本发明提供了用于选择应接受或可能对用抗肿瘤坏死因子α（抗TNFα）疗法治疗有反应的银屑病（Ps）或银屑病关节炎（PsA）的个体的方法。 此外，本文提供了用于选择具有Ps或PsA的个体的方法，所述个体应该接受或者可能对不是抗-TNFα疗法的疗法响应，例如用于治疗Ps的非抗TNFα疗法 或PsA。 具体而言，本发明的方法涉及检测PDE3A-SLCO1C1基因座的不同等位基因的存在，其与对Ps或PsA患者的抗TNFα疗法或非抗TNF疗法的临床反应有关。

公开(公告)号：EP2418288A1

公开(公告)日：2012-02-15

申请号：EP10382224.3

申请日：2010-08-09

申请人： Hospital Clinic de Barcelona ,  Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)

发明人： Sánchez Fueyo, Alberto ,  Lozano Salvatella, Juan José ,  Martínez Llordella, Marc ,  Rimola Castella, Antoni ,  Bohne, Félix

IPC分类号： C12Q1/68

CPC分类号： G01N33/84 ,  C12N15/1072 ,  C12Q1/6881 ,  C12Q2600/158 ,  G01N33/6872 ,  G01N33/74

摘要： Method and kit for the diagnosis or prognosis of tolerance in liver transplantation employing liver tissue. The invention refers to a method and kit for the in vitro diagnosis or prognosis of the tolerant state of a patient subjected to a liver transplantation that comprises measuring the expression levels, in vitro, in samples of liver tissue (biopsies), of at least one of the following genes or combination or equivalent thereof: TFRC, CDHR2, HMOX1, MIF, HAMP, IFNG, PEBP1, SLC5A12, ADORA3 and DAB2.

摘要翻译： 方法和试剂盒用于容忍的肝移植用人肝组织中的诊断或预后。 本发明涉及一种用于经受肝移植患者的耐受状态的体外诊断或预后的方法和试剂盒也包括测量在体外的表达水平，在至少一个的肝组织（活检）样品 的下列基因或组合或等同物：TFRC，CDHR2，HMOX1，MIF，HAMP，IFNG，PEBP1，SLC5A12，ADORA3和DAB 2。