公开(公告)号：EP3638814A1

公开(公告)日：2020-04-22

申请号：EP18733500.5

申请日：2018-06-05

申请人： The United States of America, as Represented by The Secretary, Department of Health and Human Services Office of Technology Transfer ,  British Columbia Cancer Agency Branch ,  Mayo Foundation for Medical Education and Research ,  Julius-Maximilians-Universitaet Wuerzburg ,  The Board of Regents of the University of Nebraska ,  Oslo University Hospital HF ,  University of Health Network ,  Hospital Clinic De Barcelona ,  Universitat de Barcelona ,  Institut D'Investigacions Biomèdiques August Pi I Sunyer - IDIBAPS ,  Robert Bosch Gesellschaft für medizinische Forschung mbH ,  Oregon Health & Science University ,  City of Hope ,  The Cleveland Clinic Foundation

发明人： STAUDT, Louis M. ,  STEIDL, Christian ,  MOTTOK, Anja ,  WRIGHT, George W. ,  SCOTT, David William ,  RIMSZA, Lisa M. ,  ROSENWALD, Andreas ,  GASCOYNE, Randy ,  GREINER, Timothy ,  WEISENBURGER, Dennis ,  SMELAND, Erlend B. ,  DELABIE, Jan ,  CAMPO GUERRI, Elias ,  OTT, German ,  BRAZIEL, Rita ,  JAFFE, Elaine S. ,  FU, Kai ,  CHAN, Wing C. ,  SONG, Joo ,  COOK, James R.

IPC分类号： C12Q1/6886

公开(公告)号：EP3445873B1

公开(公告)日：2020-11-04

申请号：EP17724960.4

申请日：2017-04-20

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency Branch ,  Julius-Maximilians-University of Wuerzburg ,  Oregon Health & Science University ,  Hospital Clínic de Barcelona ,  Universitat de Barcelona ,  Oslo University Hospital HF ,  Board of Regents of the University of Nebraska ,  The Cleveland Clinic Foundation ,  Mayo Foundation for Medical Education and Research

发明人： STAUDT, Louis M. ,  SCOTT, David William ,  WRIGHT, George W. ,  ROSENWALD, Andreas ,  ABRISQUETA, Pau ,  BRAZIEL, Rita M. ,  CAMPO GUERRI, Elias ,  CHAN, Wing C. ,  CONNORS, Joseph M. ,  DELABIE, Jan ,  VILLA, Diego ,  FU, Kai ,  GASCOYNE, Randy D. ,  GREINER, Timothy C. ,  JAFFE, Elaine S. ,  JARES, Pedro ,  MOTTOK, Anja ,  OTT, German ,  RIMSZA, Lisa M. ,  SLACK, Graham ,  WEISENBURGER, Dennis D. ,  SMELAND, Erlend B. ,  COOK, James Robert

IPC分类号： A61P7/00 ,  A61P35/00 ,  A61P35/02 ,  C12Q1/6886

公开(公告)号：EP2294420A2

公开(公告)日：2011-03-16

申请号：EP09759517.7

申请日：2009-06-05

申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services ,  British Columbia Cancer Agency Branch ,  UNIVERSITY OF ROCHESTER ,  Oregon Health&Science University ,  Arizona Board of Regents on behalf of The University of Arizona ,  Queen Mary And Westfield College, University Of London ,  Board of Regents of the University of Nebraska ,  University of Rochester ,  Universitat de Barcelona Hospital Clinic ,  Oslo University Hospital HF ,  Julius-Maximilians-University of Wuerzburg

发明人： STAUDT, Louis, M. ,  RIMSZA, Lisa ,  LISTER, Andrew T. ,  WEISENBURGER, Dennis ,  DELABIE, Jan ,  SMELAND, Erlend B. ,  HOLTE, Harald ,  KVALOY, Stein ,  BRAZIEL, Rita M. ,  FISHER, Richard I. ,  JARES, Pedro ,  LOPEZ-GUILLERMO, Armando ,  GUERRI, Elias Campo ,  JAFFE, Elaine S. ,  LENZ, George ,  WYNDHAM, Wilson H. ,  WRIGHT, George ,  DAVE, Sandeep S. ,  GASCOYNE, Randy D. ,  CONNORS, Joseph M. ,  MÜLLER-HERMELINK, Hans-Konrad ,  ROSENWALD, Andreas ,  OTT, German

IPC分类号： G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/57407 ,  G01N2800/52 ,  G01N2800/56

摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.

公开(公告)号：EP2294420B8

公开(公告)日：2015-10-21

申请号：EP09759517.7

申请日：2009-06-05

申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services ,  British Columbia Cancer Agency Branch ,  UNIVERSITY OF ROCHESTER ,  Oregon Health & Science University ,  Arizona Board of Regents on behalf of The University of Arizona ,  Queen Mary And Westfield College, University Of London ,  Board of Regents of the University of Nebraska ,  Universitat de Barcelona Hospital Clinic ,  Oslo University Hospital HF ,  Julius-Maximilians-University of Wuerzburg ,  Hospital Clinic

发明人： STAUDT, Louis, M. ,  RIMSZA, Lisa ,  LISTER, Andrew T. ,  WEISENBURGER, Dennis ,  DELABIE, Jan ,  SMELAND, Erlend B. ,  HOLTE, Harald ,  KVALOY, Stein ,  BRAZIEL, Rita M. ,  FISHER, Richard I. ,  JARES, Pedro ,  LOPEZ-GUILLERMO, Armando ,  GUERRI, Elias Campo ,  JAFFE, Elaine S. ,  LENZ, Georg ,  WYNDHAM, H.Wilson. ,  WRIGHT, George ,  DAVE, Sandeep S. ,  GASCOYNE, Randy D. ,  CONNORS, Joseph M. ,  MÜLLER-HERMELINK, Hans-Konrad ,  ROSENWALD, Andreas ,  OTT, German ,  WING, C Chan

IPC分类号： G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/57407 ,  G01N2800/52 ,  G01N2800/56

摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.

公开(公告)号：EP3594359A1

公开(公告)日：2020-01-15

申请号：EP19170689.4

申请日：2014-11-05

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency Branch ,  Arizona Board of Regents on Behalf of University of Arizona ,  Universitat de Barcelona ,  Hospital Clínic de Barcelona ,  Cleveland Clinic ,  Board of Regents of the University of Nebraska ,  Oregon Health & Science University ,  Julius-Maximilians-University of Wuerzburg ,  Oslo University Hospital HF

发明人： STAUDT, Louis M. ,  WRIGHT, George W. ,  SCOTT, David William ,  CONNORS, Joseph M. ,  GASCOYNE, Randy D. ,  RIMSZA, Lisa ,  CAMPO GUERRI, Elias ,  GREINER, Timothy C. ,  COOK, James Robert ,  FU, Kai ,  WILLIAMS, Paul Michael ,  LIH, Chih-Jian ,  JAFFE, Elaine S. ,  BRAZIEL, Rita M. ,  ROSENWALD, Andreas ,  SMELAND, Erlend B. ,  CHAN, Wing C. ,  OTT, German ,  DELABIE, Jan ,  WEISENBURGER, Dennis ,  TUBBS, Raymond

IPC分类号： C12Q1/68

摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

公开(公告)号：EP3066215B1

公开(公告)日：2019-04-24

申请号：EP14803288.1

申请日：2014-11-05

申请人： The United States of America, represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency Branch ,  Arizona Board of Regents on Behalf of University of Arizona ,  Universitat de Barcelona ,  Hospital Clínic de Barcelona ,  Cleveland Clinic ,  Board of Regents of the University of Nebraska ,  Oregon Health & Science University ,  Julius-Maximilians-University of Wuerzburg ,  Oslo University Hospital HF

发明人： STAUDT, Louis M. ,  WRIGHT, George W. ,  SCOTT, David William ,  CONNORS, Joseph M. ,  GASCOYNE, Randy D. ,  RIMSZA, Lisa ,  CAMPO GUERRI, Elias ,  GREINER, Timothy C. ,  COOK, James Robert ,  FU, Kai ,  WILLIAMS, Paul Michael ,  LIH, Chih-Jian ,  JAFFE, Elaine S. ,  BRAZIEL, Rita M. ,  ROSENWALD, Andreas ,  SMELAND, Erlend B. ,  CHAN, Wing C. ,  OTT, German ,  DELABIE, Jan ,  WEISENBURGER, Dennis ,  TUBBS, Raymond

IPC分类号： C12Q1/68

公开(公告)号：EP3066215A1

公开(公告)日：2016-09-14

申请号：EP14803288.1

申请日：2014-11-05

申请人： The United States of America, represented by the Secretary, Department of Health and Human Services ,  British Columbia Cancer Agency Branch ,  Arizona Board of Regents on Behalf of University of Arizona ,  Universitat de Barcelona ,  Hospital Clínic de Barcelona ,  Cleveland Clinic ,  Board of Regents of the University of Nebraska ,  Oregon Health & Science University ,  Julius-Maximilians-University of Wuerzburg ,  Oslo University Hospital HF

发明人： STAUDT, Louis M. ,  WRIGHT, George W. ,  SCOTT, David William ,  CONNORS, Joseph M. ,  GASCOYNE, Randy D. ,  RIMSZA, Lisa ,  CAMPO GUERRI, Elias ,  GREINER, Timothy C. ,  COOK, James Robert ,  FU, Kai ,  WILLIAMS, Paul Michael ,  LIH, Chih-Jian ,  JAFFE, Elaine S. ,  BRAZIEL, Rita M. ,  ROSENWALD, Andreas ,  SMELAND, Erlend B. ,  CHAN, Wing C. ,  OTT, German ,  DELABIE, Jan ,  WEISENBURGER, Dennis ,  TUBBS, Raymond

IPC分类号： C12Q1/68

CPC分类号： G06F19/20 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/166 ,  G06F19/12

摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

摘要翻译： 本发明涉及用于选择活化的B细胞样弥漫性大B细胞淋巴瘤（ABC DLBCL）受试者，生发中心B细胞样弥漫性大B细胞淋巴瘤（GCB DLBCL）受试者，原发性纵隔 B细胞淋巴瘤（PMBL）受试者，伯基特淋巴瘤（BL）受试者或套细胞淋巴瘤（MCL）受试者，通过分析从受试者获得的数字基因表达数据，例如来自活组织检查样品。

公开(公告)号：EP2294420B1

公开(公告)日：2015-08-12

申请号：EP09759517.7

申请日：2009-06-05

申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services ,  British Columbia Cancer Agency Branch ,  UNIVERSITY OF ROCHESTER ,  Oregon Health & Science University ,  Arizona Board of Regents on behalf of The University of Arizona ,  Queen Mary And Westfield College, University Of London ,  Board of Regents of the University of Nebraska ,  University of Rochester ,  Universitat de Barcelona Hospital Clinic ,  Oslo University Hospital HF ,  Julius-Maximilians-University of Wuerzburg ,  Hospital Clinic

发明人： STAUDT, Louis, M. ,  RIMSZA, Lisa ,  LISTER, Andrew T. ,  WEISENBURGER, Dennis ,  DELABIE, Jan ,  SMELAND, Erlend B. ,  HOLTE, Harald ,  KVALOY, Stein ,  BRAZIEL, Rita M. ,  FISHER, Richard I. ,  JARES, Pedro ,  LOPEZ-GUILLERMO, Armando ,  GUERRI, Elias Campo ,  JAFFE, Elaine S. ,  LENZ, Georg ,  WYNDHAM, H.Wilson. ,  WRIGHT, George ,  DAVE, Sandeep S. ,  GASCOYNE, Randy D. ,  CONNORS, Joseph M. ,  MÜLLER-HERMELINK, Hans-Konrad ,  ROSENWALD, Andreas ,  OTT, German ,  WING, C Chan

IPC分类号： G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  G01N33/57407 ,  G01N2800/52 ,  G01N2800/56

摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.