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    LOW DOSE SINGLE STEP GRATING BASED X-RAY PHASE CONTRAST IMAGING
    4.
    发明公开
    LOW DOSE SINGLE STEP GRATING BASED X-RAY PHASE CONTRAST IMAGING 有权
    NIEDRIGDOSIERTE EINZELSCHRITT-RÖNTGEN-PHASENKONTRASTDARSTELLUNG AUF GRATING-BASIS

    公开(公告)号：EP2400891A1

    公开(公告)日：2012-01-04

    申请号：EP10703260.9

    申请日：2010-02-03

    申请人： Institute Of High Energy Physics ,  Paul Scherrer Institut

    发明人： ZHU, Peiping ,  WU, Ziyu ,  STAMPANONI, Marco

    IPC分类号： A61B6/00 ,  G01N23/04

    CPC分类号： G01N23/04 ,  A61B6/00 ,  A61B6/4291 ,  A61B6/484

    摘要： Phase sensitive X-ray imaging methods can provide substantially increased contrast over conventional absorption based imaging, and therefore new and otherwise inaccessible information. The use of gratings as optical elements in hard X-ray phase imaging overcomes some of the problems that have impaired the wider use of phase contrast in X-ray radiography and tomography. So far, to separate the phase information from other contributions detected with a grating interferometer, a phase-stepping approach has been considered, which implies the acquisition of multiple radiographic projections. Here, an innovative, highly sensitive X-ray tomographic phase contrast imaging approach is presented based on grating interferometry, which extracts the phase contrast signal without the need of phase stepping. Compared to the existing phase step approach, the main advantage of this new method dubbed "reverse projection" is the significantly reduced delivered dose, without degradation of the image quality. The new technique sets the pre-requisites for future fast and low dose phase contrast imaging methods, fundamental for imaging biological specimens and in-vivo studies.

    摘要翻译： 相对于常规的基于吸收的成像技术，相敏X射线成像方法提供了显着增加的对比度，因此提供了新的或其他不可接近的信息。 在硬X射线相位成像中使用光栅作为光学元件克服了在X射线摄影和断层摄影中损害更广泛地使用相位对比度的一些问题。 为了将相位信息与用光栅干涉仪检测到的其他贡献分离，已经考虑了相位步进方法，这意味着获取多个射线照相投影。 在这里，基于光栅干涉法提出了一种创新的，高灵敏度的X射线断层扫描相位成像方法，其提取相位差信号而不需要相位步进。 与现有的相步法相比，这种被称为“反向投影”的新方法的主要优点是显着降低了递送剂量，而不会降低图像质量。