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    PROCESS FOR ISOLATION OF MYCOPHENOLIC ACID
    4.
    发明公开
    PROCESS FOR ISOLATION OF MYCOPHENOLIC ACID 审中-公开
    式分离方法麦考酚酸

    公开(公告)号：EP1786914A1

    公开(公告)日：2007-05-23

    申请号：EP05796231.8

    申请日：2005-09-09

    申请人： Ivax Corporation ,  Ivax Pharmaceuticals S.R.O.

    发明人： CVAK, Ladislav ,  FAUSTMANN, Jiri ,  SATKE, Josef

    IPC分类号： C12P17/04 ,  C07D307/88

    CPC分类号： C12P17/04 ,  C07D307/88

    摘要： Mycophenolic acid can be isolated from fermentation broth easily with low consumption of organic solvents to produce mycophenolic acid that is surprisingly high in purity. The process can be accomplished by addition of a suitable base to the whole fermentation broth, i.e., a suspension obtained by submerged cultivation of a microorganism producing mycophenolic acid, to increase pH of the liquid phase to the value from about (9) to about (13). Mycophenolic acid is thus extracted from the mycelium to the liquid phase and the exhausted mycelium can be separated easily by filtration.

    MEDICAMENT DISPENSING DEVICE WITH A MULTIMATERIAL DIAPHRAGM BOUNDING A PNEUMATIC FORCE CHAMBER
    7.
    发明公开
    MEDICAMENT DISPENSING DEVICE WITH A MULTIMATERIAL DIAPHRAGM BOUNDING A PNEUMATIC FORCE CHAMBER 有权
    随着对气压缸动力捐赠划定多材料REED药物

    公开(公告)号：EP1289589A2

    公开(公告)日：2003-03-12

    申请号：EP01944390.2

    申请日：2001-06-08

    申请人： Ivax Corporation ,  NORTON HEALTHCARE LIMITED

    发明人： HOLROYD, Michael

    IPC分类号： A61M15/00

    CPC分类号： A61M15/0091 ,  A61M15/009 ,  A61M15/0093 ,  A61M15/0096 ,  Y10T156/10

    摘要： A metered dose inhaler for use with a pressurized aerosol container (25) which is preferably breath-actuated. A preload (460) is applied to the internal aerosol valve by an amount sufficient to result in a dose release, but this is prevented by the application of a pneumatic resisting force. The inhaler comprises a release device (520) which, upon actuation, releases the resisting force and allows the preload to actuate the aerosol valve. A metered dose of medicament is then released for inhalation by the patient. The pneumatic resisting force is established by a negative pressure region (600) defined in part by a diaphragm (440). The diaphragm (440) includes a central disk (441) of a first, relatively high stiffness material 'A' and a peripheral ring, coupled by a flexure of a second, relatively low stiffness material 'B'.

    METHODS FOR THE TREATMENT OF MALE AND FEMALE SEXUAL DYSFUNCTION
    9.
    发明公开
    METHODS FOR THE TREATMENT OF MALE AND FEMALE SEXUAL DYSFUNCTION 审中-公开
    方法男性性功能障碍与女性治疗

    公开(公告)号：EP1648471A2

    公开(公告)日：2006-04-26

    申请号：EP04780074.3

    申请日：2004-08-02

    申请人： Ivax Corporation

    发明人： BODOR, Nicholas, S.

    IPC分类号： A61K31/58

    CPC分类号： A61K9/006 ,  A61K9/0056 ,  A61K47/6951 ,  B82Y5/00

    摘要： Use of 17β-[(1-methyl-1,4-dihydro-3-pyridinyl)carbonyloxy]estra-1,3,5(10) trien-3-ol, also known as E2-CDS, in the preparation of a medicament for treating female sexual dysfunction in a female mammal, employing very low doses of the compound which do not elevate average steady-state peripheral estradiol levels to above about 50-60 pg/ml. Also, use of E2-CDS in the preparation of a medicament for treating male sexual function in a male mammal, employing very low doses of the compound which do not substantially elevate average peripheral estradiol levels to above average normal peripheral levels in the male mammal.