公开(公告)号：EP2763677B1

公开(公告)日：2020-02-26

申请号：EP12837804.9

申请日：2012-10-03

Applicant: Janus Biotherapeutics, Inc. ,  Lipford, Grayson, B. ,  Zepp, Charles, M.

Inventor： LIPFORD, Grayson, B. ,  ZEPP, Charles, M.

IPC: A61K31/535 ,  C07D471/00 ,  A01N43/42 ,  A61K31/44

公开(公告)号：EP3183251A1

公开(公告)日：2017-06-28

申请号：EP15833999.4

申请日：2015-08-21

Applicant: Janus Biotherapeutics, Inc.

Inventor： LIPFORD, Grayson B. ,  ZEPP, Charles M.

IPC: C07D475/08 ,  C07D475/00 ,  C07D475/10

CPC classification number: C07D475/08 ,  A61K31/165 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5375 ,  C07D475/00 ,  C07D475/02 ,  C07D475/06

Abstract: Compounds as immune system modulators bearing a pteridine core are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing autoimmunity disease using the same are described.

Abstract translation: 描述了带有蝶啶核心的免疫系统调节剂的化合物。 描述了包含其的药物组合物，其制备方法，以及使用该组合物治疗或预防自身免疫疾病的方法。

公开(公告)号：EP2713737B1

公开(公告)日：2016-04-20

申请号：EP12793946.0

申请日：2012-06-01

Applicant: Janus Biotherapeutics, Inc.

Inventor： LIPFORD, Grayson, B. ,  ZEPP, Charles, M.

IPC: A01N43/90 ,  A61K31/52 ,  C07D473/00 ,  C07D473/24 ,  C07D473/32 ,  C07D473/38 ,  C07D473/40 ,  C07D473/34 ,  C07D473/30

CPC classification number: C07D473/34 ,  C07D473/24 ,  C07D473/30 ,  C07D473/32 ,  C07D473/38 ,  C07D473/40

公开(公告)号：EP2713737A4

公开(公告)日：2014-11-26

申请号：EP12793946

申请日：2012-06-01

Applicant: JANUS BIOTHERAPEUTICS INC

Inventor： LIPFORD GRAYSON B ,  ZEPP CHARLES M

IPC: A01N43/90 ,  A61K31/52 ,  C07D473/00 ,  C07D473/24 ,  C07D473/30 ,  C07D473/32 ,  C07D473/34 ,  C07D473/38 ,  C07D473/40

CPC classification number: C07D473/34 ,  C07D473/24 ,  C07D473/30 ,  C07D473/32 ,  C07D473/38 ,  C07D473/40

公开(公告)号：EP3398948A3

公开(公告)日：2018-12-05

申请号：EP18177058.7

申请日：2015-08-21

Applicant: Janus Biotherapeutics, Inc.

Inventor： LIPFORD, Grayson B ,  ZEPP, Charles M

IPC: C07D475/02 ,  C07D475/06 ,  C07D475/00 ,  C07D475/08 ,  A61K31/519 ,  A61P19/00 ,  A61P17/00 ,  A61P3/00

CPC classification number: C07D475/08 ,  A61K31/165 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5375 ,  C07D475/00 ,  C07D475/02 ,  C07D475/06

Abstract: Compounds as immune system modulators bearing a pteridine core are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing autoimmunity disease using the same are described.

公开(公告)号：EP2763677A4

公开(公告)日：2015-05-20

申请号：EP12837804

申请日：2012-10-03

Applicant: JANUS BIOTHERAPEUTICS INC ,  LIPFORD GRAYSON B ,  ZEPP CHARLES M

Inventor： LIPFORD GRAYSON B ,  ZEPP CHARLES M

IPC: A61K31/535 ,  A01N43/42 ,  A61K31/44 ,  C07D471/00

CPC classification number: C07D471/04

Abstract: The present invention relates to a compound of Formula I: or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.

公开(公告)号：EP2713736A4

公开(公告)日：2014-12-03

申请号：EP12792545

申请日：2012-06-01

Applicant: JANUS BIOTHERAPEUTICS INC

Inventor： LIPFORD GRAYSON B ,  ZEPP CHARLES M

IPC: A01N43/90 ,  A61K31/519 ,  C07D239/00

CPC classification number: C07D475/00 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  C07D475/02 ,  C07D475/06 ,  C07D475/08 ,  C07D475/10 ,  C07D487/04

Abstract: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐，其中符号如说明书中所定义; 包含其的药物组合物; 以及使用其治疗或预防自身免疫性疾病的方法。

公开(公告)号：EP2763677A2

公开(公告)日：2014-08-13

申请号：EP12837804.9

申请日：2012-10-03

Applicant: Janus Biotherapeutics, Inc. ,  Lipford, Grayson, B. ,  Zepp, Charles, M.

Inventor： LIPFORD, Grayson, B. ,  ZEPP, Charles, M.

IPC: A61K31/535 ,  C07D471/00 ,  A01N43/42 ,  A61K31/44

CPC classification number: C07D471/04

Abstract: The present invention relates to a compound of Formula I: or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.

Abstract translation: 本发明涉及式I化合物或其对映异构体，非对映异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中符号如说明书中所定义; 包含其的药物组合物; 以及使用其治疗或预防自身免疫性疾病的方法。

公开(公告)号：EP2713737A1

公开(公告)日：2014-04-09

申请号：EP12793946.0

申请日：2012-06-01

Applicant: Janus Biotherapeutics, Inc.

Inventor： LIPFORD, Grayson, B. ,  ZEPP, Charles, M.

IPC: A01N43/90 ,  A61K31/52 ,  C07D473/00

CPC classification number: C07D473/34 ,  C07D473/24 ,  C07D473/30 ,  C07D473/32 ,  C07D473/38 ,  C07D473/40

Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐，其中符号如说明书中所定义; 包含其的药物组合物; 以及使用其治疗或预防自身免疫疾病的方法。

公开(公告)号：EP2713736A1

公开(公告)日：2014-04-09

申请号：EP12792545.1

申请日：2012-06-01

Applicant: Janus Biotherapeutics, Inc.

Inventor： LIPFORD, Grayson, B. ,  ZEPP, Charles, M.

IPC: A01N43/90 ,  A61K31/519 ,  C07D239/00

CPC classification number: C07D475/00 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  C07D475/02 ,  C07D475/06 ,  C07D475/08 ,  C07D475/10 ,  C07D487/04 ,  Y02A50/411

Abstract: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.