公开(公告)号：EP2416760A1

公开(公告)日：2012-02-15

申请号：EP10772790.1

申请日：2010-05-05

申请人： Alnylam Pharmaceuticals, Inc. ,  Manoharan, Muthiah ,  Rajeev, Kallanthottathil G. ,  Jayaraman, Muthusamy ,  Butler, David ,  Jung, Michael, E.

发明人： MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil, G. ,  JAYARAMAN, Muthusamy ,  BUTLER, David ,  JUNG, Michael, E.

IPC分类号： A61K9/127 ,  A61K31/50

CPC分类号： A61K47/22 ,  A61K9/1272 ,  C07D295/13 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  Y02A50/463

摘要： Disclosed herein are lipid compositions comprising a cationic lipid formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I).