专利检索 ap:"Levine, Bruce L." 第 1 页

1.

发明公开
METHODS FOR IMPROVING THE EFFICACY AND EXPANSION OF CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS 审中-公开
标题翻译：提高表达嵌合抗原受体的细胞的效力和扩展的方法

公开(公告)号：EP3283619A1

公开(公告)日：2018-02-21

申请号：EP16720247.2

申请日：2016-04-15

申请人： Barrett, David Maxwell , Bedoya, Felipe , Ghassemi, Saba , June, Carl, H. , Levine, Bruce L. , Melenhorst, Jan J. , Milone, Michael C. , Powell, Daniel, J. , Singh, Nathan Amar , Zheng, Zoe

发明人： Barrett, David Maxwell , Bedoya, Felipe , Ghassemi, Saba , June, Carl, H. , Levine, Bruce L. , Melenhorst, Jan J. , Milone, Michael C. , Powell, Daniel, J. , Singh, Nathan Amar , Zheng, Zoe

IPC分类号： C12N5/0783 , C07K14/47 , C07K14/705 , C12N5/00 , A61K35/17

CPC分类号： A61K39/0011 , A61K35/17 , A61K38/50 , A61K45/06 , A61K2039/5156 , A61K2039/5158 , C07K14/4748 , C07K14/705 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/28 , C07K2317/622 , C07K2319/00 , C12N5/0636 , C12N2501/2302 , C12N2501/2305 , C12N2501/2307 , C12N2501/2318 , C12Y305/01001 , A61K2300/00

摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.