公开(公告)号：EP3405204A2

公开(公告)日：2018-11-28

申请号：EP16885394.3

申请日：2016-11-01

申请人： RESTEM LLC

发明人： GONZALEZ, Rafael

IPC分类号： A61K35/51 ,  C12N5/02 ,  C12M3/00

CPC分类号： C12N5/0606 ,  C12N5/0665 ,  C12N2501/10 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/13 ,  C12N2501/148 ,  C12N2501/15 ,  C12N2501/165 ,  C12N2501/17 ,  C12N2501/21 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/2303 ,  C12N2501/2304 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2308 ,  C12N2501/2318 ,  C12N2501/25 ,  C12N2502/025 ,  C12N2533/54 ,  C12N2533/90

摘要： The invention provides methods for using Umbilical Cord Lining Stem Cells (ULSCs) to produce therapeutic factors including growth factors, cytokines, chemokines and extracellular matrix components. ULSCs are mesenchymal stem cells isolated from umbilical cord lining. They can be efficiently propagated and expanded in vitro. Under specific conditions ULSCs produce useful therapeutic factors that can be used to treat injuries and degenerative conditions.

公开(公告)号：EP3283619A1

公开(公告)日：2018-02-21

申请号：EP16720247.2

申请日：2016-04-15

申请人： Barrett, David Maxwell ,  Bedoya, Felipe ,  Ghassemi, Saba ,  June, Carl, H. ,  Levine, Bruce L. ,  Melenhorst, Jan J. ,  Milone, Michael C. ,  Powell, Daniel, J. ,  Singh, Nathan Amar ,  Zheng, Zoe

发明人： Barrett, David Maxwell ,  Bedoya, Felipe ,  Ghassemi, Saba ,  June, Carl, H. ,  Levine, Bruce L. ,  Melenhorst, Jan J. ,  Milone, Michael C. ,  Powell, Daniel, J. ,  Singh, Nathan Amar ,  Zheng, Zoe

IPC分类号： C12N5/0783 ,  C07K14/47 ,  C07K14/705 ,  C12N5/00 ,  A61K35/17

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/50 ,  A61K45/06 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K16/28 ,  C07K2317/622 ,  C07K2319/00 ,  C12N5/0636 ,  C12N2501/2302 ,  C12N2501/2305 ,  C12N2501/2307 ,  C12N2501/2318 ,  C12Y305/01001 ,  A61K2300/00

摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

公开(公告)号：EP3405567A1

公开(公告)日：2018-11-28

申请号：EP17742046.0

申请日：2017-01-20

申请人： Fate Therapeutics, Inc.

发明人： ROSEN, Jonathan ,  REZNER, Betsy ,  VALAMEHR, Bahram ,  BJORDAHL, Ryan ,  PERALTA, Eigen

IPC分类号： C12N5/0783 ,  A61K35/17

CPC分类号： A61K35/17 ,  A61K31/00 ,  C12N5/0636 ,  C12N5/0646 ,  C12N2501/06 ,  C12N2501/2312 ,  C12N2501/2318 ,  C12N2501/25 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2503/02 ,  G01N33/505 ,  Y02A50/467 ,  A61K2300/00

摘要： Compounds that either produced a higher proportion or greater absolute number of phenotypically identified nave, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified. Compositions and methods for modulating immune cells including T, NK, and NKT cells for adoptive cell therapies with improved efficacy are provided.

公开(公告)号：EP3310173A1

公开(公告)日：2018-04-25

申请号：EP16800648.4

申请日：2016-05-25

申请人： CELULARITY, INC.

发明人： KARASIEWICZ-MENDEZ, Kathy, E. ,  FRANCKI, Aleksandar ,  TURNER, Jeffrey ,  LAW, Eric ,  PAREDES, Jennifer ,  LABAZZO, Kristen ,  RANA, Hemlata ,  HOFGARTNER, Wolfgang ,  HARIRI, Robert, J.

IPC分类号： A01N63/00 ,  C12N5/00

CPC分类号： C12N5/0605 ,  A61K9/0019 ,  A61K9/0085 ,  A61K35/28 ,  A61K35/50 ,  A61K47/36 ,  A61K47/42 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3895 ,  A61P9/10 ,  C12N5/069 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/2308 ,  C12N2501/2318 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2502/025

摘要： Provided herein are stimulated placental stem cells and methods of treating individuals having diseases or disorders of the circulatory system using stimulated placental cells. The invention also provides methods of inducing angiogenesis using such stimulated cells or populations of cells comprising such stimulated cells.