公开(公告)号：EP1711455A4

公开(公告)日：2007-11-07

申请号：EP05711747

申请日：2005-01-21

Applicant: UNIV PENNSYLVANIA ,  DEGRADO WILLIAM F ,  LIU DAHUI ,  TEW GREGORY N ,  KLEIN MICHAEL L

Inventor： DEGRADO WILLIAM F ,  LIU DAHUI ,  TEW GREGORY N ,  KLEIN MICHAEL L

IPC: C07C211/00 ,  A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78 ,  C07C279/12

CPC classification number: C07C279/12 ,  A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78

公开(公告)号：EP1711455A2

公开(公告)日：2006-10-18

申请号：EP05711747.5

申请日：2005-01-21

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  Degrado, William F. ,  Liu, Dahui ,  Tew, Gregory N. ,  Klein, Michael L.

Inventor： DEGRADO, William F. ,  LIU, Dahui ,  TEW, Gregory N. ,  KLEIN, Michael L.

IPC: C07C211/00

CPC classification number: C07C279/12 ,  A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78

Abstract: The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.