公开(公告)号：EP4452930A1

公开(公告)日：2024-10-30

申请号：EP22850846.1

申请日：2022-12-16

Applicant: Beam Therapeutics Inc.

Inventor： SAGO, Cory Dane ,  HAMILTON, Gregory Lawrence

IPC: C07C233/78 ,  C07C69/612 ,  A61K9/127 ,  A61K47/00 ,  C12N9/22 ,  C12N9/78

公开(公告)号：EP3154934A1

公开(公告)日：2017-04-19

申请号：EP15730461.9

申请日：2015-06-15

Applicant: Université de Lille 2 Droit et Santé ,  Centre Hospitalier Régional et Universitaire de Lille

Inventor： MELNYK, Patricia ,  VERMERSCH, Patrick ,  CARATO, Pascal ,  OXOMBRE-VANTEGHEM, Bénédicte ,  ZEPHIR, Hélène ,  DONNIER-MARECHAL, Marion

IPC: C07C255/57 ,  C07C311/37 ,  C07C211/27 ,  C07C211/29 ,  C07C233/78 ,  C07C235/50 ,  C07C237/20 ,  C07C237/34 ,  C07D209/08 ,  A61P25/00 ,  A61K31/132 ,  A61K31/137 ,  A61K31/165 ,  A61K31/166 ,  A61K31/167 ,  A61K31/18

CPC classification number: C07C233/78 ,  A61K49/00 ,  C07C211/27 ,  C07C211/29 ,  C07C235/50 ,  C07C237/10 ,  C07C237/20 ,  C07C237/34 ,  C07C255/57 ,  C07C255/60 ,  C07C311/37 ,  C07D209/08 ,  C07D209/44

Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.

Abstract translation: 本发明涉及式（I）的新化合物，其药学上可接受的盐或溶剂化物，以及它们的用途。

公开(公告)号：EP3112343A1

公开(公告)日：2017-01-04

申请号：EP15755910.5

申请日：2015-02-27

Applicant: Tohoku University ,  National University Corporation Gunma University ,  Fuso Pharmaceutical Industries, Ltd.

Inventor： KIKUCHI, Haruhisa ,  OSHIMA, Yoshiteru ,  HATTORI, Toshio ,  KUBOHARA, Yuzuru ,  YAMADA, Osamu ,  ZHANG, Jing ,  MATSUSHITA, Yoshihisa ,  KIDA, Shinya

IPC: C07C235/50 ,  A61K31/165 ,  A61K31/166 ,  A61K31/351 ,  A61K31/4045 ,  A61K31/437 ,  A61P1/16 ,  A61P9/10 ,  A61P11/00 ,  A61P13/04 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C233/36 ,  C07C233/62 ,  C07C233/78 ,  C07C235/48

CPC classification number: C07C235/50 ,  A61K31/165 ,  A61K31/166 ,  A61K31/167 ,  A61K31/351 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4045 ,  A61K31/437 ,  A61K31/4409 ,  A61K31/445 ,  C07C233/36 ,  C07C233/62 ,  C07C233/78 ,  C07C235/48 ,  C07C235/60 ,  C07C237/22 ,  C07C237/34 ,  C07C237/42 ,  C07C2101/14 ,  C07C2601/14 ,  C07D205/04 ,  C07D207/16 ,  C07D209/14 ,  C07D211/60 ,  C07D213/81 ,  C07D309/08 ,  C07D333/38 ,  C07D471/04

Abstract: The present invention provides a useful medicament for the treatment and/or prophylaxis of a disease associated with the enhancement of OPN production including cancer, which comprises a compound of formula:

wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , m, n, p, X, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明提供了一种治疗和/或预防与包括癌症在内的OPN产生增强有关的疾病的有用药物，其包含下式的化合物：其中R 1，R 2，R 3，R 4，R 5， R 6，R 7，m，n，p，X和Y如说明书中所定义，或其药学上可接受的盐。

公开(公告)号：EP2448914B1

公开(公告)日：2014-11-26

申请号：EP10725033.4

申请日：2010-06-09

Applicant: Clariant Finance (BVI) Limited

Inventor： KRULL, Matthias ,  MORSCHHÄUSER, Roman

IPC: C07C231/02 ,  C07D209/48 ,  C07C233/65 ,  C07C233/78 ,  C07D213/82

CPC classification number: C07C231/02 ,  B01J19/126 ,  C07D209/48 ,  C07D213/82 ,  C07C233/65 ,  C07C233/78

公开(公告)号：EP2468711A3

公开(公告)日：2012-09-19

申请号：EP12000444.5

申请日：2005-01-21

Applicant: The Trustees Of The University Of Pennsylvania

Inventor： Degrado, William, F. ,  Liu, Dahui ,  Tew, Gregory, N. ,  Klein, Michael, L.

IPC: C07C211/00 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78 ,  C07C279/12

CPC classification number: C07C279/12 ,  A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78

Abstract: The present invention discloses facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers of formula (Ia), compositions thereof, preparation thereof and their use as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy

        R 1 -A 1 -s-A 2 -s-A 1 -R 2      Formula (Ia)

wherein A 1 and A 2 are independently substituted or unsubstituted arylene or heteroarylene, s is absent, or -CH=CH- or C≡C- and R 1 and R 2 are as defined in claim 1. Examples of compounds of formula (Ia) are the following

公开(公告)号：EP2448914A1

公开(公告)日：2012-05-09

申请号：EP10725033.4

申请日：2010-06-09

Applicant: Clariant Finance (BVI) Limited

Inventor： KRULL, Matthias ,  MORSCHHÄUSER, Roman

IPC: C07C231/02 ,  C07D209/48 ,  C07C233/65 ,  C07C233/78 ,  C07D213/82

CPC classification number: C07C231/02 ,  B01J19/126 ,  C07D209/48 ,  C07D213/82 ,  C07C233/65 ,  C07C233/78

Abstract: The invention relates to a continuous method for producing amides of aromatic carboxylic acids by reacting at least one carbonic acid ester of formula (I) R
3 -COOR
4 , wherein R
3 represents an optionally substituted aromatic hydrocarbon group with 5 to 100 carbon atoms and R
4 represents a hydrocarbon group with 1 to 30 carbon atoms, with at least one amine of formula (II) HNR
1 R
2 , wherein R
1 and R
2 independently represent hydrogen or a hydrocarbon group with 1 to 100 C atoms, in a reaction tube the longitudinal axis of which extends in the direction of propagation of the microwaves of a monomode microwave applicator, under microwave irradiation to form carboxamide.

公开(公告)号：EP1711455A4

公开(公告)日：2007-11-07

申请号：EP05711747

申请日：2005-01-21

Applicant: UNIV PENNSYLVANIA ,  DEGRADO WILLIAM F ,  LIU DAHUI ,  TEW GREGORY N ,  KLEIN MICHAEL L

Inventor： DEGRADO WILLIAM F ,  LIU DAHUI ,  TEW GREGORY N ,  KLEIN MICHAEL L

IPC: C07C211/00 ,  A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78 ,  C07C279/12

CPC classification number: C07C279/12 ,  A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78

公开(公告)号：EP1716851A4

公开(公告)日：2007-10-17

申请号：EP05719200

申请日：2005-02-16

Applicant: ISHIHARA SANGYO KAISHA

Inventor： KATO FUMINORI ,  KIMURA HIROHIKO ,  TAMAI KIYOSHI ,  YAMAMOTO KAZUHIRO ,  SANO MITSUO ,  MORI SHINYA ,  OKADA TAKASHI ,  UEKI TOSHIHIKO ,  AZUMA KUMIKO

IPC: A61K31/166 ,  C07D237/20 ,  A61K31/18 ,  A61K31/352 ,  A61K31/401 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4192 ,  A61K31/423 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/47 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61P3/10 ,  A61P5/14 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P17/04 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P27/14 ,  A61P27/16 ,  A61P29/00 ,  A61P37/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07C233/66 ,  C07C233/69 ,  C07C233/71 ,  C07C233/78 ,  C07C311/17 ,  C07C323/42 ,  C07C327/48 ,  C07D207/09 ,  C07D209/04 ,  C07D209/08 ,  C07D209/42 ,  C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D213/81 ,  C07D213/82 ,  C07D213/83 ,  C07D215/20 ,  C07D215/22 ,  C07D231/18 ,  C07D231/20 ,  C07D235/08 ,  C07D237/04 ,  C07D239/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/60 ,  C07D241/12 ,  C07D241/18 ,  C07D249/18 ,  C07D257/04 ,  C07D263/58 ,  C07D277/20 ,  C07D277/36 ,  C07D277/74 ,  C07D311/08 ,  C07D311/46 ,  C07D401/12 ,  C07D471/04

CPC classification number: C07D239/34 ,  C07C233/66 ,  C07C233/69 ,  C07C233/71 ,  C07C233/78 ,  C07C323/42 ,  C07C327/48 ,  C07C2603/74 ,  C07D213/83 ,  C07D239/42

Abstract: The invention provides cytokine production inhibitors useful as preventive or therapeutic agents for diseases accompanied with abnormally enhanced immune function. Cytokine production inhibitors containing as the active ingredient thioamides represented by the general formula (I) or salts thereof: wherein A is N, NO, C-NO2, or C-CN; Hal is halogeno; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, a heterocycle, amino, O, S, SO, or SO2; M2 is amino, O, S, or a single bond; R1 is halogeno, alkyl, or the like; R2 R3, R4 and R5 are each independently H, alkyl, or the like; R6 is halogeno, alkyl, or the like; Cy is cycloalkyl, cycloalkenyl, aryl, or a heterocycle; k, p and q are each independently an integer of 0 to 3; and r is an integer of 0 to 5.

Abstract translation: 提供细胞因子产生抑制剂，作为伴有过度活化免疫功能的疾病的预防或治疗药物。 含有式（I）所示的硫代酰胺化合物或其盐作为活性成分的细胞因子产生抑制剂：其中A为N，NO，C-NO 2或C-CN; 卤素是卤素; M 1是烷基，烯基，炔基，环烷基，环烯基，芳基，杂环基，氨基，O，S，SO或SO 2; M 2是氨基，O，S或单键; R 1是卤素，烷基等; R 2，R 3，R 4和R 5各自独立地为H，烷基等; R 6是卤素，烷基等; Cy是环烷基，环烯基，芳基或杂环基; k，p和q各自独立地为0〜3的整数; r为0〜5的整数。

公开(公告)号：EP1838663A1

公开(公告)日：2007-10-03

申请号：EP05820721.8

申请日：2005-12-21

Applicant: GLAXO GROUP LIMITED

Inventor： BRADLEY, Daniel Marcus, GlaxoSmithKline ,  BRANCH, Clive Leslie, GlaxoSmithKline ,  CHAN, Wai Ngor, GlaxoSmithKline ,  COULTON, Steven, GlaxoSmithKline ,  GILPIN, Martin Leonard, GlaxoSmithKline ,  HARRIS, Andrew Jonathan, GlaxoSmithKline ,  LAI, Justine Yeun Quai, GlaxoSmithKline ,  MARSHALL, Howard Robert, GlaxoSmithKline ,  MACRITCHIE, Jacqueline A., Biofocus Discovery Ltd. ,  NASH, David John, GlaxoSmithKline ,  PORTER, Roderick Alan, GlaxoSmithKline ,  SPADA, Simone, GlaxoSmithKline SpA ,  THEWLIS, Kevin Michael, GlaxoSmithKline ,  WARD, Simon Edward, GlaxoSmithKline

IPC: C07C233/78 ,  A61K31/166 ,  C07C211/27

CPC classification number: C07C235/60 ,  C07C211/27 ,  C07C233/78 ,  C07C235/50 ,  C07C323/62

Abstract: The present invention relates to compounds of Formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.

Abstract translation: 本发明涉及式（I）化合物或其盐或溶剂化物，其在制备用于治疗神经和神经精神病症，特别是精神病，痴呆或注意力缺陷障碍的药物中的用途。 本发明还包括制备这些化合物及其药物制剂的方法。

公开(公告)号：EP1794115A2

公开(公告)日：2007-06-13

申请号：EP05783710.6

申请日：2005-09-09

Applicant: Pfizer Products Incorporated

Inventor： KLEINMAN, Edward Fox, Pfizer Global Res. & Dev. ,  MURRAY, John Charles, Pfizer Global Res. & Dev.

IPC: C07C233/78 ,  A61K31/16 ,  A61P25/28

CPC classification number: C07C233/78 ,  C07D213/81 ,  C07D213/82

Abstract: An N-ethyl hydroxyethyleneamine of formula (I) are disclosed which are useful in treating CNS conditions, including neurodegenerative diseases such as Alzheimer's Disease.