公开(公告)号：EP2380971B1

公开(公告)日：2020-02-12

申请号：EP11159624.3

申请日：2004-03-29

申请人： Mesoblast, Inc.

发明人： Gronthos, Stan ,  Zannettino, Andrew ,  Shi, Songtao

IPC分类号： C12N5/0775 ,  A61K35/28

公开(公告)号：EP2380969B1

公开(公告)日：2018-07-04

申请号：EP11155631.2

申请日：2004-03-29

申请人： Mesoblast, Inc.

发明人： Gronthos, Stan ,  Zannettino, Andrew

IPC分类号： C12N5/00 ,  C12N5/0775 ,  A61K35/28

CPC分类号： C12N5/0663 ,  A61K9/0014 ,  A61K35/28 ,  A61K35/44 ,  A61K38/00 ,  C12N5/0668 ,  C12N5/0691 ,  C12N2500/42 ,  C12N2501/11 ,  C12N2501/135 ,  C12N2501/165 ,  C12N2501/235 ,  C12N2501/39 ,  C12N2506/1392 ,  A61K2300/00

摘要： Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilising a perivascular marker. A new mesenchymal precursor cell phenotype is described characterised by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as MUC 18, VCAM-1 and STRO-1 bri . The perivascular mesenchymal precursor cell is multipotential and is shown to form, vascular tissue, as well as bone marrow dentin and pulp. A method of enriching using cell sorting based on these markers is also described.

公开(公告)号：EP2931876A1

公开(公告)日：2015-10-21

申请号：EP13862555.3

申请日：2013-12-12

申请人： Mesoblast, Inc.

发明人： KIMPTON, Wayne Gregory ,  BAILEY, Simon Reeves ,  ITESCU, Silviu ,  GHOSH, Peter

IPC分类号： C12N5/077 ,  A61K35/28 ,  A61P13/12 ,  A61P9/00 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K9/0019 ,  A61K31/7028 ,  C12N5/0663

摘要： The present disclosure provides a method for treating or preventing endothelial dysfunction in a subject, the method comprising systemically administering to the subject a population of population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.

公开(公告)号：EP2753342A4

公开(公告)日：2015-03-11

申请号：EP12829951

申请日：2012-09-07

申请人： MESOBLAST INC

发明人： ITESCU SILVIU ,  KRISHNAN RAVI

IPC分类号： A61K35/28 ,  A61K35/12 ,  A61P19/08 ,  A61P19/10 ,  C12N5/071 ,  C12N5/077 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K2035/124 ,  C12N5/0663

摘要： The present disclosure provides methods of increasing osteoblastic function in a subject, the method comprising systemically administering to the subject a population of stem cells and/or progeny thereof and/or soluble factors derived therefrom.

公开(公告)号：EP2709634A4

公开(公告)日：2014-12-17

申请号：EP12785672

申请日：2012-05-18

申请人： MESOBLAST INC

发明人： KRISHNAN RAVI ,  ITESCU SILVIU

IPC分类号： A61K35/12 ,  A61K35/28 ,  A61P3/04 ,  C12N5/077

CPC分类号： A61K35/28 ,  C12N5/0663

摘要： The present disclosure provides methods of treating or preventing obesity or causing weight loss or treating or preventing metabolic syndrome comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.

摘要翻译： 本公开提供了治疗或预防肥胖症或引起体重减轻或治疗或预防代谢综合征的方法，包括向受试者施用富含STRO-1 +细胞和/或其后代的细胞群和/或由其衍生的可溶性因子。

公开(公告)号：EP2593115A1

公开(公告)日：2013-05-22

申请号：EP11799996.1

申请日：2011-07-04

申请人： Mesoblast, Inc.

发明人： ITESCU, Silviu ,  SCHUSTER, Michael, David

IPC分类号： A61K35/28 ,  C12N5/077 ,  A61P37/06 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K45/06 ,  A61K2035/122 ,  A61P37/02 ,  C12N5/0663

摘要： A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.

公开(公告)号：EP2294184A4

公开(公告)日：2013-03-06

申请号：EP09794792

申请日：2009-06-29

申请人： MESOBLAST INC

发明人： SCHUSTER MICHAEL DAVID ,  ITESCU SILVIU

IPC分类号： C12N5/0775 ,  A61K35/28 ,  A61K39/395 ,  C07K16/22

CPC分类号： C07K16/22 ,  A61K35/28 ,  A61K2035/124 ,  A61K2039/505 ,  C07K2317/76 ,  C12N5/0663

摘要： The present invention relates to methods of treating or preventing eye diseases, as well as angiogenesis-related diseases, by combination therapy involving administration of cells and a compound that disrupts VEGF-signalling.

公开(公告)号：EP2729155B1

公开(公告)日：2019-10-30

申请号：EP12807117.2

申请日：2012-07-04

申请人： Mesoblast, Inc.

发明人： GHOSH, Peter ,  ITESCU, Silviu

IPC分类号： A61K35/28 ,  A61P19/02 ,  A61P37/06 ,  C12N5/077 ,  C12N5/0789

公开(公告)号：EP2324359B1

公开(公告)日：2018-10-31

申请号：EP09807748.0

申请日：2009-08-18

申请人： Mesoblast, Inc.

发明人： GRONTHOS, Stan ,  ZANNETTINO, Andrew, Christopher, William

IPC分类号： G01N33/50 ,  C07K16/18 ,  C12N5/0775

CPC分类号： C07K16/28 ,  A61K35/28 ,  A61K2035/124 ,  C07K16/18 ,  C07K2317/24 ,  C12N5/0663 ,  G01N33/5044 ,  G01N33/56966 ,  G01N2333/4703

摘要： The present invention relates to a monoclonal antibody designated STRO-4 which specifically binds human and ovine HSP-90beta and its use for enriching multipotential cells such as mesenchymal precursor cells (MPCs).

公开(公告)号：EP2303290B1

公开(公告)日：2018-07-25

申请号：EP09768629.9

申请日：2009-06-25

申请人： Mesoblast, Inc.

发明人： GHOSH, Peter

IPC分类号： A61K35/12 ,  A61K35/28 ,  A61K35/32 ,  A61P19/02 ,  A61P19/04

CPC分类号： A61K35/12 ,  A61K31/726 ,  A61K31/727 ,  A61K31/728 ,  A61K35/28 ,  A61K47/36 ,  A61K2035/124 ,  A61L27/3834 ,  A61L27/3856 ,  A61L27/52 ,  A61L2430/38 ,  C12N5/0663 ,  C12N2501/905 ,  A61K2300/00

摘要： This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1 + multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.