公开(公告)号：EP2195038A1

公开(公告)日：2010-06-16

申请号：EP08806958.8

申请日：2008-08-29

申请人： Omrix Biopharmaceuticals Ltd.

发明人： BECHOR, Edna ,  BAR, Liliana ,  NUR, Israel

IPC分类号： A61L27/22 ,  A61K38/36 ,  C12N5/06

CPC分类号： A61K35/16 ,  A61K35/545 ,  A61K38/1709 ,  A61K38/363 ,  A61L27/3616 ,  A61L27/3804 ,  A61L27/3856 ,  A61L27/3878 ,  A61L2430/38 ,  C12N5/0655 ,  C12N2500/84 ,  A61K2300/00

摘要： The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating, regenerating, repopulating injured Nucleus Pulposus cells/tissue, notochord derived tissue, and/or tissue whose formation is guided by notochordal cells, e.g. spinal intervertebral disc and/or central nervous system such as spine.

摘要翻译： 本发明涉及使用病毒灭活血浆冷沉淀浓缩物（VIPCC），包括用于治疗，再生，重新填充受伤髓核细胞/组织，脊索来源的组织合适的纤连蛋白/纤维蛋白原比率的，和/或组织其形成由脊索引导 细胞，例如 脊柱椎间盘和/或中枢神经系统：如脊柱。

公开(公告)号：EP2034010A1

公开(公告)日：2009-03-11

申请号：EP07115352.2

申请日：2007-08-30

申请人： Omrix Biopharmaceuticals Ltd.

发明人： Bechor, Edna ,  Bar, Lily ,  Nur, Israel

IPC分类号： C12N5/06 ,  A61L27/22 ,  A61L27/50

CPC分类号： A61K35/16 ,  A61K35/545 ,  A61K38/1709 ,  A61K38/363 ,  A61L27/3616 ,  A61L27/3804 ,  A61L27/3856 ,  A61L27/3878 ,  A61L2430/38 ,  C12N5/0655 ,  C12N2500/84 ,  A61K2300/00

摘要： The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating, regenerating, repopulating injured Nucleus Pulposus cells/tissue, notochord derived tissue, and/or tissue whose formation is guided by notochordal cells, e.g. spinal intervertebral disc and/or central nervous system such as spine.

摘要翻译： 本发明涉及使用病毒灭活血浆冷沉淀浓缩物（VIPCC），包括用于治疗，再生，重新填充受伤髓核细胞/组织，脊索来源的组织合适的纤连蛋白/纤维蛋白原比率的，和/或组织其形成由脊索引导 细胞，例如 脊柱椎间盘和/或中枢神经系统：如脊柱。

公开(公告)号：EP1706157A2

公开(公告)日：2006-10-04

申请号：EP04816270.5

申请日：2004-12-13

申请人： Co.Don AG

发明人： JOSIMOVIC-ALASEVIC, Olivera ,  LIBERA, Jeanette ,  SIODLA, Vilma ,  MEISEL, Hans-Jörg

IPC分类号： A61L27/38 ,  C12N5/06

CPC分类号： A61L27/3658 ,  A61F2002/4445 ,  A61F2002/445 ,  A61L27/3612 ,  A61L27/3817 ,  A61L27/3856 ,  A61L2430/38

摘要： The invention relates to a method for the in vitro production of intervertebral disk cartilage cell transplants from patients with diseased intervertebral disk tissue and to the use thereof as transplant material for the treatment of diseased intervertebral disks. The invention also relates to three-dimensional, vital and mechanically stable intervertebral disk cartilage tissue and to the use thereof as transplant material for the treatment of diseased intervertebral disks, and to the testing of active substances. The invention further relates to the produced intervertebral disk cell transplants and the produced intervertebral disk cartilage tissue and therapeutical preparations, e.g. injection solutions which contain said tissue and the cell transplants.

公开(公告)号：EP1673047A1

公开(公告)日：2006-06-28

申请号：EP04785021.9

申请日：2004-09-24

申请人： DePuy AcroMed, Inc.

发明人： SERHAN, Hassan ,  SLIVKA, Michael

IPC分类号： A61F2/44 ,  A61F2/46 ,  A61L27/36

CPC分类号： A61L27/3804 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30293 ,  A61F2002/30588 ,  A61F2002/30601 ,  A61F2002/30971 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2002/4627 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2230/0091 ,  A61F2310/00365 ,  A61L27/3629 ,  A61L27/3658 ,  A61L27/3683 ,  A61L27/3856 ,  A61L2430/38

摘要： A minimally invasive nucleus pulposus augmentation or replacement methods and corsponding devices comprising small intestine submucosa (sis) are disclosed. The method relates to insertion of nucleus pulposus augmentation or replacement materials comprising small intestine submucosa (sis) to help maintain disc height and promote regeneration of the native nucleus pulposus structure. The devices are shaped in an dongated form like strips, cords, braids, tubes, rolls or pellets. They may comprise bioactive factors or seeding cells.

公开(公告)号：EP1610833A2

公开(公告)日：2006-01-04

申请号：EP04720517.4

申请日：2004-03-12

申请人： SDGI Holdings, Inc.

发明人： TRIEU, Hai, H.

IPC分类号： A61L27/38

CPC分类号： A61L27/3834 ,  A61F2/442 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30677 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2210/0004 ,  A61F2250/0098 ,  A61F2310/00365 ,  A61L27/3856 ,  A61L27/3895 ,  A61L2430/38 ,  C12N5/0667 ,  C12N2500/25 ,  C12N2501/105 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/39

摘要： A method of augmenting and/or repairing an intervertebral disc by administering stem cell material into the disc. The stem cells may be undifferentiated cells, or they may be cells that have differentiated and have subsequently been dedifferentiated. The stem cells may be induced to express at least one characteristic of human intervertebral disc cells, such as fibroblast cells, chondrocyte cells, or notochordal cells, by exposing them to agents and/or environments calculated to induce the desired differentiation. In some embodiments, the stem cell material may be provided in conjunction with a collagen-based material, which may be a collagen-rich lattice. The stem cell material may be provided as a stem cell isolate, which may be substantially free of non-stem cell material. Other therapeutic agents may be administered with the stem cell material.

公开(公告)号：EP1585448A1

公开(公告)日：2005-10-19

申请号：EP03815954.7

申请日：2003-12-29

申请人： Abbott Spine

发明人： MEUNIER, Alain ,  SENEGAS, Jacques ,  LE COUEDIC, Régis

IPC分类号： A61B17/70 ,  A61L27/38 ,  A61F2/46

CPC分类号： A61L27/3834 ,  A61B17/7053 ,  A61B17/7062 ,  A61F2/4611 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2002/4627 ,  A61L27/3821 ,  A61L27/3856 ,  A61L2430/38

摘要： The invention relates to a unit for treatment of the degeneration of an injured intervertebral disc arranged between two vertebrae. The treatment unit comprises cells (16) analogous or not to the cells of the intervertebral disc for implantation in said disc and an intervertebral implant (10) comprising an intervertebral wedge (12), for arrangement between two of said vertebrae and means (14) for fixing said wedge to said vertebrae.

公开(公告)号：EP1465489A4

公开(公告)日：2005-09-28

申请号：EP02780657

申请日：2002-11-14

申请人： MEDTRONIC SOFAMOR DANEK

发明人： MCKAY WILLIAM F ,  BODEN SCOTT D ,  YOON SANGWOOK T

IPC分类号： A61K35/12 ,  A61K48/00 ,  A61L27/38 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C12N5/08 ,  C12N5/22 ,  C12N5/16 ,  C12N15/63

CPC分类号： A61K48/005 ,  A61K35/12 ,  A61K35/13 ,  A61K48/00 ,  A61K2121/00 ,  A61L27/3804 ,  A61L27/3856 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/78 ,  C07K16/18 ,  C12N2799/022

摘要： Methods of expressing LIM mineralization protein in non-osseous mammalian cells, such as stem cells or intervertebral disc cells (e.g., cells of the annulus fibrosus, or cells of the nucleus pulposus) are described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding a LIM mineralization protein operably linked to a promoter. Transfection may be accomplished ex vivo or in vivo by direct injection of virus or naked DNA, or by a nonviral vector such as a plasmid. Expression of the LIM mineralization protein can stimulate proteoglycan and/or collagen production in cells capable of producing proteoglycyan and/or collagen. Methods for treating disc disease associated with trauma or disc degeneration are also described.

公开(公告)号：EP3378483A1

公开(公告)日：2018-09-26

申请号：EP18170227.5

申请日：2009-06-25

申请人： Mesoblast, Inc.

发明人： Ghosh, Peter

IPC分类号： A61K35/12 ,  A61K35/28 ,  A61K35/32 ,  A61P19/02 ,  A61P19/04

CPC分类号： A61K35/12 ,  A61K31/726 ,  A61K31/727 ,  A61K31/728 ,  A61K35/28 ,  A61K47/36 ,  A61K2035/124 ,  A61L27/3834 ,  A61L27/3856 ,  A61L27/52 ,  A61L2430/38 ,  C12N5/0663 ,  C12N2501/905 ,  A61K2300/00

摘要： This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1 + multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.

公开(公告)号：EP1464307B1

公开(公告)日：2007-08-22

申请号：EP04251928.0

申请日：2004-03-31

申请人： DePuy Spine, Inc.

发明人： Dimauro, Thomas M. ,  Serhan, Hassan

IPC分类号： A61F2/44 ,  A61L27/38 ,  A61L27/36

CPC分类号： A61L27/3834 ,  A61F2/30965 ,  A61F2/447 ,  A61F2002/0086 ,  A61F2002/2817 ,  A61F2002/30014 ,  A61F2002/30266 ,  A61F2002/30331 ,  A61F2002/30599 ,  A61F2002/30879 ,  A61F2002/3093 ,  A61F2002/30968 ,  A61F2002/30971 ,  A61F2002/445 ,  A61F2220/0033 ,  A61F2230/0082 ,  A61F2250/0018 ,  A61F2250/0063 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61F2310/00592 ,  A61L27/3856 ,  A61L27/3895 ,  A61L27/56 ,  A61L2430/38

公开(公告)号：EP1620024B1

公开(公告)日：2007-04-04

申请号：EP04760924.3

申请日：2004-05-07

申请人： Aleeva Medical, Inc.

发明人： YEUNG, Jeffrey, E.

IPC分类号： A61B17/88

CPC分类号： A61L27/3658 ,  A61B17/00 ,  A61B17/7061 ,  A61F2/94 ,  A61F2002/444 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/3856 ,  A61L2430/38

摘要： The intervertebral disc is avascular. With aging, endplates become occluded by calcified layers, and diffusion of nutrients and oxygen into the disc diminishes. The disc degenerates, and pain ensues. Conduits are delivered and deployed into the intervertebral disc to reestablish the exchange of nutrients and waste between the disc and bodily circulation to stop or reverse disc degeneration and relieve pain. The intervertebral disc installed with semi-permeable conduits may be used as an immuno-isolated capsule to encapsulate donor cells capable of biosynthesizing therapeutic molecules. The semi-permeable conduits establish the exchange of nutrients and therapeutic molecules between disc and bodily circulation to treat a disease without using immunosuppressive drugs.