公开(公告)号：EP1675869A2

公开(公告)日：2006-07-05

申请号：EP04796096.8

申请日：2004-10-22

申请人： CHIRON CORPORATION ,  Magagnoli, Claudia ,  Morandi, Maurizio

发明人： MAGAGNOLI, Claudia ,  MORANDI, Maurizio

IPC分类号： C07K14/195

CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K38/45 ,  A61K39/00 ,  A61K47/183 ,  A61K47/186 ,  A61K2039/55544 ,  C07K14/195 ,  Y02A50/472

摘要： This invention relates to the stabilization of a bacterial ADP-ribosylating exotoxin class protein (bARE), a method for analysing a bARE class protein, a method for the stabilization of the bARE class bacterial protein, compositions comprising a stabilized bARE protein, compositions comprising a substantially integral bARE class protein and immunogenic composition formulations incorporating same.

公开(公告)号：EP1675869B1

公开(公告)日：2012-02-15

申请号：EP04796096.8

申请日：2004-10-22

申请人： Novartis Vaccines and Diagnostics, Inc. ,  Magagnoli, Claudia ,  Morandi, Maurizio

发明人： MAGAGNOLI, Claudia ,  MORANDI, Maurizio

IPC分类号： A61K47/18 ,  A61K9/00 ,  C07K14/195 ,  A61K39/39 ,  A61K38/45

CPC分类号： A61K39/39 ,  A61K9/0019 ,  A61K38/45 ,  A61K39/00 ,  A61K47/183 ,  A61K47/186 ,  A61K2039/55544 ,  C07K14/195 ,  Y02A50/472

摘要： This invention relates to the stabilization of a bacterial ADP-ribosylating exotoxin class protein (bARE), a method for analysing a bARE class protein, a method for the stabilization of the bARE class bacterial protein, compositions comprising a stabilized bARE protein, compositions comprising a substantially integral bARE class protein and immunogenic composition formulations incorporating same.