公开(公告)号：EP2010557A2

公开(公告)日：2009-01-07

申请号：EP07754132.4

申请日：2007-03-29

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION ,  Kawaoka, Yoshihiro ,  Horimoto, Taisuke ,  Murakami, Shin

发明人： KAWAOKA, Yoshihiro ,  HORIMOTO, Taisuke ,  MURAKAMI, Shin

IPC分类号： C07K14/11

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/525 ,  A61K2039/5254 ,  C07K14/005 ,  C12N9/2402 ,  C12N15/85 ,  C12N2760/16051 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2800/107 ,  C12Y302/01018

摘要： The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes at least five internal genes from an influenza virus isolate that replicates to high titers in embryonated chicken eggs or MDCK cells.