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1.发明公开ANTIBODIES AND METHODS FOR GENERATING GENETICALLY ALTERED ANTIBODIES WITH HIGH AFFINITY 审中-公开抗体和方法对转基因抗体具有高亲和力的生产
公开(公告)号：EP1556508A2
公开(公告)日：2005-07-27
申请号：EP03754530.8
申请日：2003-09-12
发明人： GRASSO, Luigi
CPC分类号： C12N15/01 , C07K16/00 , C07K16/4291 , C07K2317/56 , C07K2317/567 , C07K2317/92 , C12N15/1024
摘要： Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulins genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the affinity of monoclonal antibodies and monoclonal antibodies with increased affinity.
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2.发明公开ANTIBODIES AND METHODS FOR GENERATING GENETICALLY ALTERED ANTIBODIES WITH HIGH AFFINITY 审中-公开抗体和方法对转基因抗体具有高亲和力的生产
公开(公告)号：EP1556508A4
公开(公告)日：2006-10-04
申请号：EP03754530
申请日：2003-09-12
发明人： GRASSO LUIGI
CPC分类号： C12N15/01 , C07K16/00 , C07K16/4291 , C07K2317/56 , C07K2317/567 , C07K2317/92 , C12N15/1024
摘要： Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. These methods are useful for generating genetic diversity within immunoglobulins genes directed against an antigen of interest to produce altered antibodies with enhanced biochemical activity. Moreover, these methods are useful for generating antibody-producing cells with increased level of antibody production. The invention also provides methods for increasing the affinity of monoclonal antibodies and monoclonal antibodies with increased affinity.
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