-
1.发明公开
公开(公告)号：EP3325652A1
公开(公告)日：2018-05-30
申请号：EP16744695.4
申请日：2016-07-21
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Université de Tours Francois Rabelais , Centre Hospitalier Régional Universitaire de Tours , National and Kapodistrian University of Athens
发明人： HEUZE VOURC'H, Nathalie , DALLONEAU, Emilie , MAVRIDIS, Konstantinos , GOUILLEUX-GRUART, Valérie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to a method for predicting the survival time of a patient suffering from a solid cancer comprising i) determining in a tissue sample obtained from the patient the gene expression level of FcRn ii) comparing expression level determined at step i) with their predetermined reference value and iii) providing a good prognosis when expression level determined at step i) is higher than their predetermined reference value, or providing a bad prognosis when expression levels determined at step i) are lower than their predetermined reference values.
-
公开(公告)号：EP4458554A1
公开(公告)日：2024-11-06
申请号：EP23386031.1
申请日：2023-05-02
申请人： National and Kapodistrian University of Athens , Krimpenis, Agathoklis , Tzivelekis Charalampos , Sgardelis, Pavlos
IPC分类号： B29C64/124 , B29C64/188 , B29C64/232 , B29C64/241 , B29C64/245 , B29C64/30 , B33Y30/00 , B33Y40/20
摘要： A multiple-axis hybrid manufacturing machine tool (1) for manufacturing a three-dimensional part, in particular a micro-part and/or a macro-part with a microfeature. The multiple-axis hybrid manufacturing machine tool (1) extends in a first direction (1001), a second direction (1002) and a third direction (1003) that are perpendicular to each other. The multiple-axis hybrid manufacturing machine tool (1) comprises a vat photopolymerization three-dimensional printing module (100), a container module (200), a CNC processing module (300) and a platform module (400). The vat photopolymerization three-dimensional printing module (100) comprises a movable illumination device (101). The container module (200) comprises at least one photopolymer receiving container (201) for receiving a photopolymer material in liquid phase. The CNC processing module (300) comprises a movable spindle (301) for holding a milling tool (10) and/or a measuring tool. The platform module (400) comprises a movable build platform (401) that is arranged and configured for vat photopolymerization three-dimensional printing of a work piece and/or on a work piece, and preferably also for CNC processing of a work piece, on the build platform (401).
-
公开(公告)号：EP3810199A1
公开(公告)日：2021-04-28
申请号：EP18737963.1
申请日：2018-06-21
申请人： Oslo Universitetssykehus HF , Consejo Superior De Investigaciones Científicas , Universitat Politècnica de València , National and Kapodistrian University of Athens , Rotas, Georgios , Vougioukalakis, Georgios C.
-
公开(公告)号：EP3307746A1
公开(公告)日：2018-04-18
申请号：EP16727948.8
申请日：2016-05-18
发明人： KOKOTOS, George
IPC分类号： C07F9/48 , C07C259/06 , C07C335/08 , C07C233/43 , C07F9/40 , A61P35/00 , A61K31/662 , A61K31/167 , A61K31/16 , A61K31/17
CPC分类号： C07F9/4816 , A61P3/04 , A61P29/00 , A61P35/00 , A61P37/00 , C07C237/22 , C07C259/06 , C07C327/42 , C07C335/08 , C07F9/4006
摘要： Novel inhibitors of the enzyme autotaxin are described. The inhibitors contain one or two zinc-binding groups at the appropriate distance, Also described are uses thereof, such as for the inhibition of autotaxin activity and the treatment of various conditions (e.g., inflammatory conditions, cancer, obesity, autoimmune diseases).
-
5.发明公开Process for the homogenous hydrogenation of (poly)unsaturated hydrocarbons 审中-公开Verfahren zur uniformen Hydrierung von（poly）ungesättigtenKohlenwasserstoffen
公开(公告)号：EP2426191A1
公开(公告)日：2012-03-07
申请号：EP10008054.8
申请日：2010-08-02
IPC分类号： C11C3/12 , C07C5/10 , C07C5/11 , C07C29/141 , C07C229/76 , C07D213/79 , C07D215/50 , C07D215/52 , C07D471/04 , C07D487/22
CPC分类号： C07C67/303 , B01J31/2243 , B01J2231/643 , B01J2231/646 , B01J2531/23 , C07C5/10 , C07C5/11 , C07C29/141 , C07C2531/22 , C07C2601/14 , C07C2601/16 , C11C3/126 , C07C69/58 , C07C69/24 , C07C69/587 , C07C33/22 , C07C13/18 , C07C13/20
摘要： Suggested is a new process for the selective hydrogenation of (poly)unsaturated hydrocarbons, in particular polyunsaturated fatty acid alkyl esters into the respective saturated and/or monounsaturated species, of aldehydes into respective alcohols and of aromatic compounds into respective saturated cyclic compounds using homogenous catalysts in a biphasic aqueous/organic solvent system, which is characterised in that said catalysts represent complexes of main-group I-V metals with water-soluble amine ligands.
摘要翻译： 建议使用均相催化剂将（多）不饱和烃，特别是多不饱和脂肪酸烷基酯选择性氢化成各自的饱和和/或单不饱和物质的各种醇和芳族化合物分别成各自的饱和环状化合物 在两相水/有机溶剂体系中，其特征在于所述催化剂表示主要IV族金属与水溶性胺配体的络合物。
-
6.发明公开
公开(公告)号：EP2366700A8
公开(公告)日：2011-11-09
申请号：EP10386007.8
申请日：2010-03-19
申请人： National and Kapodistrian University of Athens , Kokotos, George , Kokotos, Christoforos , Limnios, Dimitrios
IPC分类号： C07D403/06
CPC分类号： C07D403/06
摘要： Organocatalysts that comprise a pyrrolidine ring and a thiodydantoin or a thioxopyrimidinone ring. The compounds are effective as catalysts in enantioselective and stereoselective organic reactions.
摘要翻译： 包含吡咯烷环和硫代二胍或硫代嘧啶酮环的有机催化剂。 该化合物在对映选择性和立体选择性有机反应中作为催化剂是有效的。
-
公开(公告)号：EP4317459A1
公开(公告)日：2024-02-07
申请号：EP22188720.1
申请日：2022-08-04
IPC分类号： C12Q1/70
摘要： A method for the quantification of SARS-CoV-2 in a sample comprising a one-step multiplex reverse transcription digital PCR assay. The method includes the simultaneous amplification of three transcripts of the N gene of SARS-CoV-2, an external control and an internal control.
-
公开(公告)号：EP4316476A1
公开(公告)日：2024-02-07
申请号：EP22386055.2
申请日：2022-08-02
发明人： Vassilikogiannakis, Georgios , Eliopoulos, G. Aristides , Stratakis, Manolis , Montagnon, Tamsyn , Kalaitzakis, Dimitris
IPC分类号： A61K31/122 , A61K31/69 , A61P35/00
摘要： The invention discloses novel 4-hydroxycyclopent-2-en-1-one derivatives as active compounds in pharmaceutical compositions for the treatment of cancer. The invention confers cytotoxic effects of the said compounds on ovarian, colorectal, cervical, hepatocellular, lung, bladder and breast carcinomas, melanoma, lymphoma and myeloma malignant cells, for the inhibition of cell cycle progression at the G2/M phase, for reducing the expression of DNA replication licensing factors and for having general cancer treatment effects. It further discloses the use of the said compositions for the treatment of platinum-resistant tumors. Another aspect of the invention is the synergetic effects of these compounds with existing cancer treatment medicaments as the proteasomal inhibitors. Finally, the synthetic methods of the active compounds of the said compositions are disclosed.
-
公开(公告)号：EP4273466A1
公开(公告)日：2023-11-08
申请号：EP22171452.0
申请日：2022-05-03
摘要： The present invention refers to the use of an encapsulated phase change material (31) in particulated form in a thermal energy storage tank of a solar heating unit (1) for heating water.
Specifically, the solar heating unit can be used for heating domestic water.-
公开(公告)号：EP2970310A1
公开(公告)日：2016-01-20
申请号：EP14770647.7
申请日：2014-03-14
发明人： JOVE, Richard , NAM, Sangkil , HORNE, David , XIE, Jun , SKALTSOUNIS, Alexios Leandros , KRITSANIDA, Marina , GABORIAUD-KOLAR, Nicolas
IPC分类号： C07D487/04 , A61K31/404 , A61P35/00
摘要： Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.013 秒)
