公开(公告)号：EP2968966A1

公开(公告)日：2016-01-20

申请号：EP14716617.7

申请日：2014-03-17

申请人： Nexstim Oy

发明人： NEUVONEN, Tuomas

IPC分类号： A61N2/00 ,  A61N2/02

CPC分类号： A61B5/0484 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/4836 ,  A61N2/006 ,  A61N2/02

摘要： A method of and system for monitoring a patient's EEG (electroencephalogram) during TMS (Transcranial Magnetic Stimulation) are disclosed. The system comprises a TMS device to generate, when in an active state, a plurality of magnetic pulses, which can be applied either as a burst, comprising a plurality of pulses grouped together, or as individual pulses, to the patient's head, in accordance with a TMS treatment protocol. An EEG system is provided to measure EEG data resulting from the TMS treatment protocol being applied to the patient. The system further comprises control means in communication with the TMD device and the EEG system, the control means being arranged to activate the EEG system during the time periods when the TMS device is not generating pulses, such that the EEG data measurement is continuously applied or interleaved with the magnetic pulses being generated in accordance with the TMS treatment protocol, so as to monitor treatment efficacy and detect potential seizures.

公开(公告)号：EP1042032B1

公开(公告)日：2004-06-30

申请号：EP98955638.6

申请日：1998-11-27

申请人： Nexstim Oy

发明人： Ilmoniemi, Risto ,  Ruohonen, Jarmo ,  Kamppuri, Janne ,  Virtanen, Juha

IPC分类号： A61N2/02

CPC分类号： A61N2/02

摘要： The present invention relates to a stimulator head of a magnetic stimulator used in the stimulation of living tissue such as the human brain. Such a stimulator head comprises a stimulator head body (3) suited for mounting the stimulator head on the magnetic stimulator equipment, at least one coil (1) which is connected to said stimulator head body (3) and is designed suitable for generating a stimulating magnetic field, and conductors (7) for passing electric current from said magnetic stimulator into any of said at least one coil (1). According to the invention, the stimulator head includes a housing (2) which is connected to said stimulator head body (3) and is designed to enclose at least one air-tight space (5) which further separates each of said at least one stimulator coil (1) from the other parts of said housing (2) facing the object being stimulated. Further according to the invention, each of said at least one coil (1) is placed in said housing (2), whereby an acoustic insulation can be attained between each of said at least one coil (1) and the object being stimulated by virtue of bringing the pressure in said air-tight space (5) to a substantially low level.

公开(公告)号：EP1366782A1

公开(公告)日：2003-12-03

申请号：EP03396048.5

申请日：2003-05-26

申请人： Nexstim Oy

发明人： Ruohonen, Jarmo

IPC分类号： A61N2/02 ,  A61N2/00

CPC分类号： A61N2/02 ,  A61N2/006

摘要： The invention relates to a method and apparatus for targeting electromagnetic stimulation on the human brain. According to the method, pulse-like electromagnetic fields are formed, which have a strong local electromagnetic maximum, the electromagnetic maximum of the field is targeted on the brain (2), the distribution, direction, and strength of the electromagnetic field arising in the brain are defined, and some physiological or biological response, such as, for example, a muscular response measured using electromyography, is measured. According to the invention, the position of the brain is defined in three-dimensional space and the position data is received in electrical form in a data-processing apparatus (8), the position data of the electromagnetic fields are received in the data-processing apparatus (8) in the same three-dimensional set of co-ordinates as the brain, the position data of the electromagnetic fields are combined with the position data of the brain (2), and a graphical presentation (9) of the position data of the electromagnetic fields and of the position data of the brain is formed with the aid of the data-processing apparatus (8).

摘要翻译： 本发明涉及一种用于对人脑进行电磁刺激的方法和装置。 根据该方法，形成脉冲状电磁场，其具有强的局部电磁最大值，磁场的电磁最大值以脑（2）为目标，电磁场的分布，方向和强度在 定义脑，并且测量一些生理或生物反应，例如使用肌电描记测量的肌肉反应。 根据本发明，在三维空间中定义大脑的位置，并且在数据处理装置（8）中以电子形式接收位置数据，在数据处理中接收电磁场的位置数据 装置（8）在与脑相同的三维坐标组中，电磁场的位置数据与大脑（2）的位置数据组合，并且位置数据的图形呈现（9） 借助于数据处理装置（8）形成大脑的电磁场和位置数据。

公开(公告)号：EP2442868A4

公开(公告)日：2014-12-03

申请号：EP09846103

申请日：2009-06-17

申请人： NEXSTIM OY

发明人： RUOHONEN JARMO ,  KARHU JARI

IPC分类号： A61N2/02 ,  A61N2/00

CPC分类号： A61N2/004 ,  A61N2/006 ,  A61N2/02

公开(公告)号：EP2750763A1

公开(公告)日：2014-07-09

申请号：EP12840705.3

申请日：2012-10-15

申请人： Nexstim Oy

发明人： PESOLA, Katja ,  AUTIO, Ilkka

IPC分类号： A61N2/02

CPC分类号： G01N37/00 ,  A61N2/006 ,  A61N2/02

摘要： The present invention relates generally to a method and apparatus for determining one or more cumulative effects of an application of transcranial magnetic stimulation to the brain of a subject,as well as a method and apparatus of representing same. According to an aspect of certain embodiments of the invention there is provided a method for determining one or more cumulative effects of an application of transcranial stimulation to one or more locations in a brain of a subject comprising the steps of applying multiple transcranial magnetic stimulation pulses to the brain,determining a dose of each of said stimulation pulses, measuring a physical response of the user and determining or approximating an accumulation of said response of said brain for each of said one or more locations in the brain of said subject.

公开(公告)号：EP2750762A1

公开(公告)日：2014-07-09

申请号：EP12784034.6

申请日：2012-10-15

申请人： Nexstim Oy

发明人： PESOLA, Katja ,  AUTIO, Ilkka

IPC分类号： A61N2/02

CPC分类号： G01R33/00 ,  A61N2/006 ,  A61N2/02

摘要： The present invention relates generally to a method and apparatus for determining one or more cumulative effects of an application of transcranial magnetic stimulation to the brain of a subject, as well as a method and apparatus of representing same. According to an aspect of certain embodiments of the invention there is provided a method for determining one or more cumulative effects of an application of transcranial stimulation to one or more locations in a brain of a subject comprising the steps of applying multiple transcranial magnetic stimulation pulses to the brain, determining a dose of each of said stimulation pulses, measuring a physical response of the user and determining or approximating an accumulation of said response of said brain for each of said one or more locations in the brain of said subject.

公开(公告)号：EP0935441B1

公开(公告)日：2006-10-11

申请号：EP97911257.0

申请日：1997-10-30

申请人： Nexstim Oy

发明人： Ilmoniemi, Risto ,  Karhu, Jari ,  Ruohonen, Jarmo ,  Virtanen, Juha

IPC分类号： A61B5/04 ,  A61B5/0484

CPC分类号： A61N2/006 ,  A61B5/04008 ,  A61B5/0484 ,  A61B5/7217 ,  A61N2/02

摘要： The invention relates to a method and apparatus for examining and mapping the reactivity of and connections between different cortical areas. In the method an electromagnetic stimulus is induced in the interior parts of the head and the electromagnetic field generated around the skull is measured by electrical means (1). According to the method, the electromagnetic activity of the brain is measured using multichannel equipment, artefacts caused by the stimulus are eliminated from the signal containing the electromagnetic activity, a visualization of the activity changes in the measured signals is formed, and the areas of the head related to said activity generating said electromagnetic field are localized, or alternatively, the maximum of the sensitivity pattern of the multichannel activity measurement system is focused to a desired point

公开(公告)号：EP1684630A1

公开(公告)日：2006-08-02

申请号：EP04798296.2

申请日：2004-11-16

申请人： Nexstim Oy

发明人： HANNULA, Henri ,  AHO, Matti ,  OLLIKAINEN, Marko

IPC分类号： A61B5/0478 ,  A61B5/04

CPC分类号： A61B5/0478 ,  A61B5/0492 ,  A61B2562/0215

摘要： The invention relates to an electrode structure (10) for attachment to a more extensive measuring structure (11), in order to measure electrical responses from the human body. The electrode structure (10) includes a conductive electrode (1). According to the invention, the electrode (1) is shaped to be thin in the thickness direction of the electrode structure (10), and the electrode structure (10) is equipped with a hole (6) and the electrode (1) is located at the edge of the hole (6), in such a way that its longitudinal axis is essentially parallel to the plane of the measurement subject.

公开(公告)号：EP2714193B1

公开(公告)日：2019-12-18

申请号：EP12737848.7

申请日：2012-06-04

申请人： Nexstim Oy

发明人： HANNULA, Henri

IPC分类号： A61N2/00 ,  A61N2/02 ,  A61B5/00 ,  A61B5/05 ,  A61B5/0488 ,  A61B5/055 ,  G06T19/00 ,  A61B90/00 ,  A61B34/20

公开(公告)号：EP2750762B1

公开(公告)日：2017-01-18

申请号：EP12784034.6

申请日：2012-10-15

申请人： Nexstim Oy

发明人： PESOLA, Katja ,  AUTIO, Ilkka

IPC分类号： A61N2/02

CPC分类号： G01R33/00 ,  A61N2/006 ,  A61N2/02