专利检索 ap:"OKLAHOMA BAPTIST MED CENTER INC" 第 1 页

1.

发明公开
METHODS AND COMPOSITIONS FOR ATTENUATING ANTIBODY-MEDIATED XENOGRAFT REJECTION IN HUMAN RECIPIENTS. 失效
标题翻译：方法和组合物的异种移植物抗体介导的排斥的障碍。

公开(公告)号：EP0661980A4

公开(公告)日：1994-11-24

申请号：EP92918977

申请日：1992-08-21

申请人： OKLAHOMA BAPTIST MED CENTER INC

发明人： GOOD A HEATHER , COOPER DAVID K C , MALCOLM ANDREW J

IPC分类号： A61K35/12 , A61K35/14 , A61K39/00 , A61M1/36 , A61P37/00 , A61K31/70 , A01N1/00 , A61K31/73 , A61K31/735 , C07K1/00 , C12S3/02 , C12S3/22

CPC分类号： A61K35/14 , A61K39/001 , A61M1/3679

摘要： Antibody-mediated xenograft rejection is attenuated by (1) removing preformed antibodies to various identified carbohydrate xenoantigens from the recipient's circulation prior to transplantation by extracorporeal perfusion of the recipient's blood over a biocompatible solid support to which the xenoantigens are bound and/or (2) parenterally administering a xenoantibody-inhibiting amount of an identified xenoantigen to the recipient shortly before graft revascularization and thereafter.