SALACIA COMPOSITIONS, METHODS OF TREATMENT BY THEIR ADMINISTRATION, AND METHODS OF THEIR PREPARATION
    2.
    发明公开
    SALACIA COMPOSITIONS, METHODS OF TREATMENT BY THEIR ADMINISTRATION, AND METHODS OF THEIR PREPARATION 审中-公开
    五层组合物,处理情况其施用方法和方法及其

    公开(公告)号:EP3071214A1

    公开(公告)日:2016-09-28

    申请号:EP14864855.3

    申请日:2014-11-19

    摘要: A Salacia composition described herein significantly reduces appetite, activates Hormone Sensitive Lipase, and manages a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme. Salacia compositions described herein include of at least 12% of polyphenols, 2% of mangiferin and 1% of 25,26-oxidofriedelane-1,3-dione by weight of the composition in the form of extract. The composition is obtained by continuous solvent extraction, employing non-aqueous food grade solvents. Salacia compositions herein reduce appetite by about 18% of routine diet, when effective amounts are administered to a subject in need thereof. Effective management of a healthy lipid profile is thus possible with synergistic combination of reduction in energy intake, activation of Hormone Sensitive Lipase, and inhibition of HMG-CoA Reductase enzyme responsible for cholesterol metabolism.

    摘要翻译: 中记载的组合物,五层龙极大减少食欲,所述激活激素敏感脂肪酶,并管理通过抑制HMG-CoA还原酶酶的健康脂质谱。 在描述的五层龙的组合物包括的多酚的至少12%,芒果苷的2%和按重量计在提取物的形式该组合物中的25,26-oxidofriedelane -1,3-二酮1%。 该组合物通过连续溶剂萃取获得,使用非水性食品级溶剂。 五层龙的组合物通过常规的饮食,当有效量施用给需要其的受试者的约18%降低食欲。 一个健康的脂质分布的有效管理是可能的减少的能量摄入,激素敏感脂肪酶的活化,以及抑制负责胆固醇代谢的HMG-CoA还原酶的。因此协同组合。