公开(公告)号：EP0262753A1

公开(公告)日：1988-04-06

申请号：EP87305037.1

申请日：1987-06-08

申请人： PACO RESEARCH CORPORATION

发明人： Kim, Benjamin K.

IPC分类号： A61M37/00 ,  A61L15/03

CPC分类号： A61K9/7053 ,  A61K9/7092 ,  A61K31/46

摘要： The present invention is directed to a transdermal delivery system for scopolamine. The delivery system is composed of multiple layers (14, 16, 18) containing a varying concentration of scopolamine base. Each layer (14, 16, 18) includes a medically acceptable rubber (such as a butyl rubber), an active substance (such as scopolamine) and a vehicle for the active substance (such as light mineral oil). Beginning with the first layer (in contact with the skin), concentration of the active substance increases from 7 % or less up to 10-16 %. This construction allows the controlled release of the active substance over a sustained period of time.

摘要翻译： 本发明涉及东莨菪碱的透皮递送系统。 递送系统由含有不同浓度的东莨菪碱碱的多层（14,16,18）组成。 每个层（14,16,18）包括医学上可接受的橡胶（例如丁基橡胶），活性物质（如东莨菪碱）和活性物质（如轻质矿物油）的载体。 从第一层（与皮肤接触）开始，活性物质的浓度从7％或更少增加到10-16％。 这种结构允许在持续的时间内控制活性物质的释放。

公开(公告)号：EP0224981A3

公开(公告)日：1988-08-10

申请号：EP86305511

申请日：1986-07-17

申请人： PACO RESEARCH CORPORATION

发明人： KIM, K. BENJAMIN

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K31/047 ,  A61K31/21 ,  A61K47/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61L15/03

CPC分类号： A61K9/0014 ,  A61K9/7069 ,  A61K31/21

摘要： A transdermal delivery system for a vasoactive substance includes, by weight, about 30 to 70% of a medically-acceptable liquid silicone rubber, about 5 to 25% of a vasoactive substance, about 0.1 to 2.0% of a gelling agent, about 2 to 15% of a material which swells as water is absorbed from the stratum corneum and about 5 to 35% of a mixture comprising one or more solvents, viscosity reducers and skin penetration enhancers including, by weight of the entire delivery system, about 5 to 25% of a solvent, about 0 to 5% of a viscosity reducer and about 5 to 25% of a skin penetration enhancer.

摘要翻译： 用于血管活性物质的经皮递送系统包括按重量计约30至70％的医学上可接受的液体硅橡胶，约5至25％的血管活性物质，约0.1至2.0％的胶凝剂，约2至 当水从角质层吸收时，15％的物质膨胀，并且包含一种或多种溶剂，粘度降低剂和皮肤渗透增强剂的混合物的约5％至35％，包括按整个递送系统的重量计约5至25 ％的溶剂，约0至5％的降粘剂和约5至25％的皮肤渗透促进剂。

公开(公告)号：EP0224981A2

公开(公告)日：1987-06-10

申请号：EP86305511.7

申请日：1986-07-17

申请人： PACO RESEARCH CORPORATION

发明人： Kim, K. Benjamin

IPC分类号： A61L15/03 ,  A61K47/00

CPC分类号： A61K9/0014 ,  A61K9/7069 ,  A61K31/21

摘要： A transdermal delivery system for a vasoactive substance includes, by weight, about 30 to 70% of a medically-acceptable liquid silicone rubber, about 5 to 25% of a vasoactive substance, about 0.1 to 2.0% of a gelling agent, about 2 to 15% of a material which swells as water is absorbed from the stratum corneum and about 5 to 35% of a mixture comprising one or more solvents, viscosity reducers and skin penetration enhancers including, by weight of the entire delivery system, about 5 to 25% of a solvent, about 0 to 5% of a viscosity reducer and about 5 to 25% of a skin penetration enhancer.

摘要翻译： 用于血管活性物质的透皮递送系统包括约30至70％的医学上可接受的液体硅橡胶，约5至25％的血管活性物质，约0.1至2.0％的胶凝剂，约2至 作为水溶胀的材料的15％从角质层吸收，以及约5至35％的包含一种或多种溶剂的混合物，粘度降低剂和皮肤渗透增强剂，包括按整个递送系统的重量计约5至25 溶剂的％，粘度降低剂的约0至5％和皮肤渗透增强剂的约5至25％。