公开(公告)号：EP0224981A2

公开(公告)日：1987-06-10

申请号：EP86305511.7

申请日：1986-07-17

申请人： PACO RESEARCH CORPORATION

发明人： Kim, K. Benjamin

IPC分类号： A61L15/03 ,  A61K47/00

CPC分类号： A61K9/0014 ,  A61K9/7069 ,  A61K31/21

摘要： A transdermal delivery system for a vasoactive substance includes, by weight, about 30 to 70% of a medically-acceptable liquid silicone rubber, about 5 to 25% of a vasoactive substance, about 0.1 to 2.0% of a gelling agent, about 2 to 15% of a material which swells as water is absorbed from the stratum corneum and about 5 to 35% of a mixture comprising one or more solvents, viscosity reducers and skin penetration enhancers including, by weight of the entire delivery system, about 5 to 25% of a solvent, about 0 to 5% of a viscosity reducer and about 5 to 25% of a skin penetration enhancer.

摘要翻译： 用于血管活性物质的透皮递送系统包括约30至70％的医学上可接受的液体硅橡胶，约5至25％的血管活性物质，约0.1至2.0％的胶凝剂，约2至 作为水溶胀的材料的15％从角质层吸收，以及约5至35％的包含一种或多种溶剂的混合物，粘度降低剂和皮肤渗透增强剂，包括按整个递送系统的重量计约5至25 溶剂的％，粘度降低剂的约0至5％和皮肤渗透增强剂的约5至25％。