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公开(公告)号：EP2691530A4
公开(公告)日：2015-01-21
申请号：EP12797634
申请日：2012-06-08
发明人： PICKER LOUIS , FRUH KLAUS , HANSEN SCOTT
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5256 , C12N7/00 , C12N2710/16121 , C12N2710/16143 , C12N2740/15034 , C12N2740/15071 , C12N2800/204
摘要： Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof.
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公开(公告)号：EP2691530A2
公开(公告)日：2014-02-05
申请号：EP12797634.8
申请日：2012-06-08
发明人： PICKER, Louis , FRUH, Klaus , HANSEN, Scott
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5256 , C12N7/00 , C12N2710/16121 , C12N2710/16143 , C12N2740/15034 , C12N2740/15071 , C12N2800/204 , Y02A50/386 , Y02A50/388 , Y02A50/394 , Y02A50/412 , Y02A50/466
摘要： Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof.
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3.发明公开METHODS AND COMPOSITIONS USEFUL IN GENERATING NON CANONICAL CD8+ T CELL RESPONSES 审中-公开用于产生非典型CD8 + T细胞应答的方法和组合物
公开(公告)号：EP3256595A1
公开(公告)日：2017-12-20
申请号：EP16749813.8
申请日：2016-02-10
申请人： Oregon Health & Science University , Fruh, Klaus , Picker, Louis , Hansen, Scott , Sacha, Jonah
发明人： FRUEH, Klaus , PICKER, Louis , HANSEN, Scott , SACHA, Jonah , MALOULI, Daniel
IPC分类号： C12N15/86 , C12N15/12 , C12N15/33 , C07K14/705 , C07K14/725 , C12N5/0783 , C12Q1/68 , A61K48/00 , A61P35/00
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C12N9/0093 , C12N15/00 , C12N2710/16143 , C12N2740/15034 , C12Q1/68 , Y02A50/412
摘要： Methods of inducing a CD8+ T cell response to a heterologous antigen in which at least 10% of the CD8+ T cells are MHC-E restricted are disclosed. The method involves immunizing with a CMV vector that does not express UL128 and UL130 proteins. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, a UL40 protein, and a US28 protein but that do not express an active UL128 and UL130 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active UL40 protein, UL128 protein, UL130 protein, and optionally a US28 protein. Also disclosed are recombinant CMV vectors comprising nucleic acids encoding a heterologous protein antigen, but that do not express an active US28 protein, UL128 protein, UL130 protein, and optionally a UL40 protein.
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公开(公告)号：EP2691530B1
公开(公告)日：2018-03-07
申请号：EP12797634.8
申请日：2012-06-08
发明人： PICKER, Louis , FRUH, Klaus , HANSEN, Scott
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5256 , C12N7/00 , C12N2710/16121 , C12N2710/16143 , C12N2740/15034 , C12N2740/15071 , C12N2800/204 , Y02A50/386 , Y02A50/388 , Y02A50/394 , Y02A50/412 , Y02A50/466
摘要： Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof.
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