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1.发明公开7-NITRO-5-PHENYL-1-(PYRROLIDIN-1-YLMETHYL)-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE AND OTHER BENZODIAZEPINE DERIVATIVES 有权7-硝基-5-苯基-1-（吡咯烷-1-基甲基）-1H-苯并[e] [1,4]二氮杂-2（3H） - 酮和苯并二氮杂其它衍生物
公开(公告)号：EP2646421A1
公开(公告)日：2013-10-09
申请号：EP11801632.8
申请日：2011-11-29
申请人： Pignataro, Giuseppe , Annunziato, Lucio , Molinaro, Pasquale , Scorziello, Antonella , Secondo, Agnese , Pannaccione, Anna , Cuomo, Ornella , Cantile, Maria , Di Renzo, Gianfranco , Caliendo, Giuseppe , Santagada, Vincenzo , Severino, Beatrice , Fiorino, Ferdinando
发明人： Pignataro, Giuseppe , Annunziato, Lucio , Molinaro, Pasquale , Scorziello, Antonella , Secondo, Agnese , Pannaccione, Anna , Cuomo, Ornella , Cantile, Maria , Di Renzo, Gianfranco , Caliendo, Giuseppe , Santagada, Vincenzo , Severino, Beatrice , Fiorino, Ferdinando
IPC分类号： C07D243/24 , C07D243/26 , A61K31/5513 , A61P9/10 , A61P25/28
CPC分类号： C07D243/24 , C07D243/26
摘要： The present invention describes compounds of formula (I), and in particular the 7- nitro-5-phenyl-1 -(pyrrolidin-1 -ylmethyl)-1 H-benzo[e][1,4]diazepin-2(3H)-one compound and their pharmaceuticall acceptable salts. The compounds of the invention are useful for medical use, particularly as active ingredient potentially useful for the treatment of cerebral ischemia and other disease characterized by deregulation of sodium and calcium homeostasis.
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2.发明授权7-NITRO-5-PHENYL-1-(PYRROLIDIN-1-YLMETHYL)-1H-BENZO[E][1,4]DIAZEPIN-2(3H)-ONE AND OTHER BENZODIAZEPINE DERIVATIVES 有权7-硝基-5-苯基-1-（吡咯烷-1-基）乙基] -1H-苯并[E] [1,4]二氮杂-2（3H） - 酮，其中苯并恶嗪衍生物
公开(公告)号：EP2646421B1
公开(公告)日：2015-05-06
申请号：EP11801632.8
申请日：2011-11-29
申请人： Pignataro, Giuseppe , Annunziato, Lucio , Molinaro, Pasquale , Scorziello, Antonella , Secondo, Agnese , Pannaccione, Anna , Cuomo, Ornella , Cantile, Maria , Di Renzo, Gianfranco , Caliendo, Giuseppe , Santagada, Vincenzo , Severino, Beatrice , Fiorino, Ferdinando
发明人： Pignataro, Giuseppe , Annunziato, Lucio , Molinaro, Pasquale , Scorziello, Antonella , Secondo, Agnese , Pannaccione, Anna , Cuomo, Ornella , Cantile, Maria , Di Renzo, Gianfranco , Caliendo, Giuseppe , Santagada, Vincenzo , Severino, Beatrice , Fiorino, Ferdinando
IPC分类号： C07D243/24 , C07D243/26 , A61K31/5513 , A61P9/10 , A61P25/28
CPC分类号： C07D243/24 , C07D243/26
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