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1.发明授权AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 有权酰胺衍生物作为离子通道配体和药物组合物及其使用方法
公开(公告)号：EP2215054B1
公开(公告)日：2011-08-31
申请号：EP08850350.3
申请日：2008-11-13
发明人： COX, Matthew , O'MAHONY, Donogh John, Roger , ESTIARTE-MARINEZ, Maria, De Los Angeles , KAWASHIMA, Tadashi , NAGAYAMA, Satoshi , SHISIDO, Yuji , TANAKA, Hirotaka , DUNCTON, Matthew, Alexander, James , CALABRESE, Andrew, Antony
IPC分类号： C07C311/08 , C07D239/72 , C07D239/94 , C07D401/12 , C07D471/04 , A61K31/18 , A61K31/47 , A61K31/436 , A61K31/497
CPC分类号： C07D215/48 , C07C311/08 , C07C2602/10 , C07D265/36 , C07D311/58 , C07D311/66 , C07D319/20 , C07D405/04
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
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2.发明公开AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 有权作为离子通道配体和药物组合物的酰胺衍生物及使用该组合物的方法
公开(公告)号：EP2215054A1
公开(公告)日：2010-08-11
申请号：EP08850350.3
申请日：2008-11-13
发明人： COX, Matthew , O'MAHONY, Donogh John, Roger , ESTIARTE-MARINEZ, Maria, De Los Angeles , KAWASHIMA, Tadashi , NAGAYAMA, Satoshi , SHISIDO, Yuji , TANAKA, Hirotaka , DUNCTON, Matthew, Alexander, James , CALABRESE, Andrew, Antony
IPC分类号： C07C311/08 , C07D239/72 , C07D239/94 , C07D401/12 , C07D471/04 , A61K31/18 , A61K31/47 , A61K31/436 , A61K31/497
CPC分类号： C07D215/48 , C07C311/08 , C07C2602/10 , C07D265/36 , C07D311/58 , C07D311/66 , C07D319/20 , C07D405/04
摘要： Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译： 公开了具有由下式表示的化学式的化合物：所述化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物的多种病症，包括作为非限制性实例的疼痛 ，炎症，创伤性损伤等。
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公开(公告)号：EP1667963A1
公开(公告)日：2006-06-14
申请号：EP04769377.5
申请日：2004-09-10
发明人： ASHCROFT, C.P., Pfizer Global Res. and Development , HESMONDHALGH, L.C., , GLADWELL, L.R., Pfizer Global Res. and Development , HARRIS, L.J., Pfizer Global Research & Development , HUGHS, M.L., Pfizer Global Research & Development , KLOTZ, J.T., Pfizer Global Research & Development , LEVETT, P.C., Pfizer Global Research & Development , MORLAND, M.C., Pfizer Global Res. and Development , THOMSON, N.M., Pfizer Global Res. and Development
IPC分类号： C07C319/20 , C07C323/20
CPC分类号： C07C319/20 , C07C323/20
摘要： The present invention is concerned with an improved process for the preparation of the selective serotonin reuptake inhibitor 3-[(Dimethylamino)methyl]-4-[4-(methylsulfanyl)phenoxy]benzenesulfonamide (L) or (D) tartrate (I) and with intermediate products therein.
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公开(公告)号：EP1255764A1
公开(公告)日：2002-11-13
申请号：EP01902583.2
申请日：2001-02-09
发明人： MANTELL, Simon JohnPfizer Global Res. and Dev. , MONAGHAN, Sandra M.Pfizer Global Res. and Dev. , STEPHENSON, Peter T.Pfizer Global Res. and Dev.
IPC分类号： C07H19/167 , A61K31/70 , C07D473/34 , C07D473/40
CPC分类号： C07D473/00 , C07H13/08 , C07H15/04 , C07H19/16
摘要： The present invention relates to the compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, composites containing, and the uses of such compounds as adenosine A2a receptor agonists.
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5.发明公开3-(1-3-(1,3-BENZOTHIAZOL-6-YL)PROPYLCARBAMOYL CYCLOALKYL)PROPANOIC ACID DERIVATIVES AS NEP INHIBITORS 审中-公开3-（1-3-（1,3-BENZOTHIAZOL-6-YL）PROPYLCARBAMOYY CYCLOALKYL）丙酸乙酯无抑制剂
公开(公告)号：EP1606272A1
公开(公告)日：2005-12-21
申请号：EP04718706.7
申请日：2004-03-09
IPC分类号： C07D277/64 , A61K31/428 , A61P15/00
CPC分类号： C07D277/64
摘要： The invention relates to inhibitors of neutral endopeptidase enzyme (NEP) of formula (I), uses thereof, processes for the preparation therof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of male and female sexual dysfunction, particularly female sexual dysfunction (FSD), especially wherein the FSD is female sexual arousal disorder (FSAD).
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6.发明授权AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME 有权AMIDDERIVATE ALS IONENKANALLIGANDEN SOWIE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN UND VERWENDUNGSVERFAHRENDAFÜR
公开(公告)号：EP2215054B8
公开(公告)日：2012-02-08
申请号：EP08850350.3
申请日：2008-11-13
发明人： COX, Matthew , O'MAHONY, Donogh John, Roger , ESTIARTE-MARINEZ, Maria, De Los Angeles , KAWASHIMA, Tadashi , NAGAYAMA, Satoshi , SHISIDO, Yuji , TANAKA, Hirotaka , DUNCTON, Matthew, Alexander, James , CALABRESE, Andrew, Antony
IPC分类号： C07C311/08 , C07D239/72 , C07D239/94 , C07D401/12 , C07D471/04 , A61K31/18 , A61K31/47 , A61K31/436 , A61K31/497
CPC分类号： C07D215/48 , C07C311/08 , C07C2602/10 , C07D265/36 , C07D311/58 , C07D311/66 , C07D319/20 , C07D405/04
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公开(公告)号：EP1353657A1
公开(公告)日：2003-10-22
申请号：EP02732099.3
申请日：2002-01-10
发明人： JENKINSON, Stephen,Pfizer Global Res. and Dev. , O'REILLY, Mark Anthony,Pfizer Global Res. and Dev , TREVETHICK, Michael A.,Pfizer Global Res. and Dev
IPC分类号： A61K31/00
CPC分类号： A61K45/06
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