-
公开(公告)号：EP1487485B1
公开(公告)日：2010-12-15
申请号：EP03712390.8
申请日：2003-03-19
CPC分类号： A61K39/39 , A61K2039/55511
摘要： The invention relates to the fields of vaccines, vaccine adjuvants, molecular biology and immunology, and generally relates to adjuvants and nucleic acid immunization techniques. More specifically, the invention relates to certain adjuvant compositions, and to vaccine and/or nucleic acid immunization strategies employing such compositions.
-
公开(公告)号：EP1161272B1
公开(公告)日：2006-10-04
申请号：EP00909515.9
申请日：2000-03-14
IPC分类号： A61M5/30
CPC分类号： A61M5/3015
摘要： A needleless syringe capable of accelerating particles into a target surface is provided. The syringe comprises a body (20, 21, 22) having a lumen with a diaphragm (26) located adjacent to a terminus thereof. Particles are delivered from an external surface of the diaphragm (26) by means of the motive force provided by the impact of a shockwave imparted to the internal surface of the diaphragm. A method for delivering particles from the needleless syringe is also provided.
摘要翻译： 提供了一种能够将颗粒加速到目标表面的无针注射器。 该注射器包括具有内腔的主体（20,21,22），该内腔具有位于其末端附近的隔膜（26）。 借助于施加到隔膜内表面的冲击波的冲击所提供的动力，颗粒从隔膜（26）的外表面递送。 还提供了用于从无针注射器递送颗粒的方法。
-
公开(公告)号：EP0734737B1
公开(公告)日：2006-06-07
申请号：EP96109925.6
申请日：1994-04-08
CPC分类号： A61M5/3015 , A61M5/2053 , A61M2205/42 , C12M35/00 , C12M35/04 , C12N15/895
-
公开(公告)号：EP1637174A3
公开(公告)日：2006-05-03
申请号：EP05028151.8
申请日：2002-07-25
IPC分类号： A61M5/30
CPC分类号： A61M5/3015 , A61M5/24
摘要： The invention provides a silencer and silencing method which ensures adequate silencing with no deleterious increase in back pressure (which creates a lift-off force) or decrease in device performance. Pressurised gas is supplied to a driver chamber by a bleed-hole having an effective bleed-hole area and, during use of the device for particle delivery, gas is vented to the atmosphere via a silencer having an effective venting area. The bleed-hole area and venting area are chosen to ensure that the mass flow rate of gas through the effective venting area is substantially equal to or greater than the mass flow rate of gas through the effective bleed-hole area. This ensures that there is no build up of gas in the silencer device which tends to increase back pressure and hence lift-off force. Preferred embodiments of the device comprise a silencer having a large volume and a small particle exit opening. Further, there is disclosed an embodiment using one or more transfer ducts to assist particle mixing.
-
公开(公告)号：EP1637173A2
公开(公告)日：2006-03-22
申请号：EP05028150.0
申请日：1994-04-08
CPC分类号： A61M5/3015 , A61M5/2053 , A61M2205/42 , C12M35/00 , C12M35/04 , C12N15/895
摘要： A needleless syringe having a membrane (34) which is ruptured by gas pressure to generate a gas flow in which particles can be entrained so as to be injected. The invention also provides a product comprising a sealed unit comprising two diaphragms which are directly or indirectly sealed to one another around their edges, and which contain particles for transdermal injection.
摘要翻译： 一种无针注射器，其具有通过气体压力破裂以产生气流的膜（34），其中颗粒可以被夹带以被注入。 本发明还提供一种包括密封单元的产品，所述密封单元包括两个隔膜，所述两个隔膜围绕它们的边缘彼此直接或间接密封并且包含用于透皮注射的颗粒。
-
公开(公告)号：EP1365824B1
公开(公告)日：2006-03-22
申请号：EP02729462.8
申请日：2002-01-11
发明人： SHELDRAKE, Colin D., PowderJect Centre , COSTIGAN, George, PowderJect Technologies Limited , BELLHOUSE Brian John Powderject Centre
IPC分类号： A61M5/30
CPC分类号： A61M5/3015 , A61M5/2053 , A61M5/3007 , A61M2005/005
摘要： There is disclosed a method of distributing particles in a flow of gas and a needleless syringe for use in the needleless injection of particles into the skin or mucosa of a vertebrate subject. The syringe has the advantage that no bursting membranes are required, reducing noise, and that the particles are substantially uniformly distributed in the gas stream. This is achieved by providing a convergence which reduces pressure of the gas flowing in the gas flow path due to the Venturi effect such that particles initially located outside of the gas flow path are drawn into the gas flow path under the action of the reduced pressure and become entrained in the gas. An exit nozzle is provided to accelerate the particles so entrained. In another aspect of the invention, there is provided a method of creating a gas flow in a needleless syringe which comprises flowing gas through a first convergence into a chamber to form a transsonic gas jet in the chamber and passing the gas jet from the chamber into a second convergence and along the nozzle. This provides an advantageous flow regime suitable for the needleless injection of powders.
-
公开(公告)号：EP1563862A2
公开(公告)日：2005-08-17
申请号：EP05010246.6
申请日：2000-06-09
IPC分类号： A61M5/30
CPC分类号： G11B20/00 , A61M5/2046 , A61M5/3015
摘要： The invention provides mechanisms to improve particle atomisation in a needleless syringe. If the particles are more evenly distributed across the cross-section of the device at the time at which they are entrained, a better footprint of particle penetration is obtainable. The particles are initially located between first and second closure means and the pressure at which said closure means open can be made to be different. Also, a transfer duct which fluidly connects a location upstream of the second closure means to a location between the first and second closure means can be provided. Furthermore, the closure means can be constituted by rupturable membranes which are scored or indented so as to provide controlled rupturing.
摘要翻译： 本发明提供了改善无针注射器中的颗粒雾化的机理。 如果颗粒在其夹带时更均匀地分布在装置的横截面上，则可获得更好的颗粒渗透覆盖。 颗粒最初位于第一和第二封闭装置之间，并且可以使所述封闭装置打开的压力不同。 而且，可以提供将第二封闭装置上游的位置流体连接到第一和第二封闭装置之间的位置的传送管道。 此外，闭合装置可以由可破裂的膜构成，其被刻痕或缩进以便提供受控的破裂。
-
公开(公告)号：EP1546347A1
公开(公告)日：2005-06-29
申请号：EP03750996.5
申请日：2003-09-29
IPC分类号： C12N15/86 , C12N15/869
CPC分类号： C12N15/87 , A61K2039/53 , C12N15/85 , C12N15/86 , C12N2710/16643 , C12N2830/60
摘要： Nucleic acid constructs comprising viral genomic nucleic acid which comprises at least two endogenous gene expression regulatory units which each comprise an endogenous promoter where the endogenous promoters of the units are active at the same phase in the viral life cycle of the virus the viral genomic nucleic acid is derived from are provided. The endogenous gene expression regulatory units are used to express particular chosen heterologous coding sequences and in particular to express heterologous antigens. The constructs can be used in a vaccine to generate an immune response against the heterologous antigens and in particular may be used in a DNA vaccine. Methods for generating the constructs and means for their administration are also provided.
-
公开(公告)号：EP1117382B1
公开(公告)日：2005-05-11
申请号：EP99954296.2
申请日：1999-10-01
发明人： MAA, Yuh-Fun
IPC分类号： A61K9/16
CPC分类号： A61K9/1676 , A61K9/0021
摘要： Spray-coated pharmaceutical powder compositions for transdermal administration using a needless syringe comprise seed particles coated with a pharmaceutical composition, the said coated seed particles having an average size of about 10 to 100 νm and having an envelope density ranging from about 0.1 to about 25g/cm3.
-
公开(公告)号：EP1196210A1
公开(公告)日：2002-04-17
申请号：EP00937100.6
申请日：2000-06-09
发明人： KENDALL, Mark A. F. , BROWN, Garry
IPC分类号： A61M5/30
CPC分类号： G11B20/00 , A61M5/2046 , A61M5/3015
摘要： The invention provides a device which seeks to ensure that substantially all the particles delivered avoid interaction with the so-called 'starting process'. There is provided a needleless injection device comprising a driver chamber (51) arranged, in use, to contain a charge of pressurised gas, a duct section (52) connected to the driver chamber (51) to receive gas therefrom and a closure means (53) for preventing the flow of gas from the driver chamber (51) to the duct section (52) until the closure means (53) is opened. Further, a dose of particles (58) is positioned within the device in the region of the closure means (53). The device is so constructed and arranged that upon opening of the closure means (53), a primary shock wave is produced to travel along the duct (52) in a downstream direction so that a substantially quasi-steady gas flow is established in the duct (52) upstream of the primary shock wave, with the dose of particles (58) being substantially wholly entrained in the substantially quasi-steady flow to be accelerated thereby and expelled from the device.
摘要翻译： 本发明提供了一种装置，其试图确保基本上所有传送的颗粒避免与所谓的“启动过程”相互作用。 提供了一种无针注射装置，包括在使用中布置成容纳一定量的加压气体的驱动器室（51），连接到驱动器室（51）以从其接收气体的管道部分（52）和封闭装置 用于防止气体从驱动室（51）流到管道部分（52）直到封闭装置（53）打开。 此外，一定剂量的颗粒（58）在封闭装置（53）的区域内定位在装置内。 该装置的构造和布置使得在打开封闭装置（53）时产生主要冲击波以沿着管道（52）在下游方向上行进，从而在管道中建立基本上准稳定的气流 （52），其中颗粒（58）的剂量基本上全部夹带在基本上准稳定的流动中，从而被加速并从装置排出。
-
-
-
-
-
-
-
-
-
搜索结果
68 条记录 (耗时 0.026 秒)
