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    COMPOSITIONS AND METHODS FOR UPREGULATING HIPPOCAMPAL PLASTICITY AND HIPPOCAMPUS-DEPENDENT LEARNING AND MEMORY
    1.
    发明公开
    COMPOSITIONS AND METHODS FOR UPREGULATING HIPPOCAMPAL PLASTICITY AND HIPPOCAMPUS-DEPENDENT LEARNING AND MEMORY 审中-公开
    组合物和高度调节的海马可塑性和海马依赖的学习和记忆方法

    公开(公告)号：EP3024467A2

    公开(公告)日：2016-06-01

    申请号：EP14828920.0

    申请日：2014-07-23

    申请人： Revalesio Corporation

    发明人： WATSON, Richard L. ,  WOOD, Anthony B. ,  ARCHAMBEAU, Gregory J. ,  GHOSH, Supurna

    IPC分类号： A61K33/00 ,  A61K9/00 ,  A61K31/58 ,  A61P25/28

    CPC分类号： A61K9/51 ,  A61K9/08 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

    摘要： Provided are methods for enhancing hippocampal plasticity and hippocampal-mediated learning and memory, and/or enhancing the synaptic maturation of neurons, and/or optimizing or enhancing neuronal synaptic transmission, and/or enhancing intracellular oxygen delivery or utilization, and/or enhancing ATP synthesis, comprising administration, to a subject in need thereof of a sufficient amount over a sufficient time, of an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures (e.g., nanobubbles) having an average diameter of less than 100 nm (e.g., in at least one subject group selected from but not limited to normal subjects, subjects recovering from neurological trauma (e.g., accidents or injury to the brain, stroke, oxygen deprivation, drowning, and asphyxia), and subjects with learning disorders (e.g., dyslexia, dyscalculia, dysgraphia, dyspraxia (sensory integration disorder), dysphasia/aphasia, auditory processing disorder, non-verbal learning disorder, visual processing disorder, and attention deficit disorder (ADD)).

    METHODS AND COMPOSITIONS FOR PROTECTING AGAINST NEUROTOXIC AGENTS
    2.
    发明公开
    METHODS AND COMPOSITIONS FOR PROTECTING AGAINST NEUROTOXIC AGENTS 审中-公开
    方法和组合物用于防止神经毒药

    公开(公告)号：EP2563121A1

    公开(公告)日：2013-03-06

    申请号：EP11775615.5

    申请日：2011-04-29

    申请人： Revalesio Corporation

    发明人： WATSON, Richard L. ,  WOOD, Anthony, B. ,  ARCHAMBEAU, Gregory, J.

    IPC分类号： A01N39/00

    CPC分类号： A61K31/58 ,  A61K9/0019 ,  A61K31/522 ,  A61K31/56 ,  A61K38/13 ,  A61K41/0004 ,  A61K45/06 ,  A61K2300/00

    摘要： Provided are methods for protecting against or reducing neurotoxicity of exposure to a neurotoxic agent, comprising administering an electrokinetically altered aqueous fluid as provided herein in an amount sufficient to provide for neuroprotection against the neurotoxic agent, preferably where protecting against or reducing loss of motor coordination in the subject exposed to the neurotoxin is afforded. In certain aspects, protecting or reducing neurotoxin-mediated neuronal apoptosis is afforded, and/or activating or inducing at least one of PI-3 kinase and Akt phosphorylation in neurons is afforded. Preferably, administering the fluid comprises administering the fluid prior to exposure to the neurotoxic agent. Additionally provided are methods for preserving or improving motor coordination in a subject having a neurodegenerative condition or disease, comprising administering an electrokinetically altered aqueous fluid as provided herein in an amount sufficient to provide for preserving or improving motor coordination in the subject.

    COMPOSITIONS AND METHODS FOR TREATING MULTIPLE SCLEROSIS
    3.
    发明公开
    COMPOSITIONS AND METHODS FOR TREATING MULTIPLE SCLEROSIS 有权
    组合物和方法的多发性硬化症治疗

    公开(公告)号：EP2282719A2

    公开(公告)日：2011-02-16

    申请号：EP09739530.5

    申请日：2009-04-27

    申请人： REVALESIO CORPORATION

    发明人： WATSON, Richard, L. ,  WOOD, Anthony, B. ,  ARCHAMBEAU, Gregory, J.

    IPC分类号： A61K9/00

    CPC分类号： A61K31/573 ,  A61K33/00 ,  A61K2300/00

    摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating inflammatory neurodegenerative condition or disease or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.

    摘要翻译： 提供了电动改变的流体（富含气体的电动流体）在用量足以提供对细胞膜电位和细胞膜电导率中的至少一个的调制在电荷稳定的含氧纳米结构的离子wässrige溶液的包含，和治疗性组合物和 使用方法在治疗炎性神经变性病症或疾病或其至少一种症状。 所述电动改变的流体或治疗性组合物和方法包括电动改变的流体ioinic与其它治疗剂组合OPTIONALLYwässrige。 特定方面提供一种用于调节或调控通过细胞膜，膜电位，膜蛋白的至少一个的调制与所述炎性应答相关的细胞内信号转导：例如膜受体，包括但不限于G蛋白偶联受体（GPCR），和 细胞间连接（例如，紧密连接，间隙连接，黏着带和桥粒）。 其他实施例包括用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物施用或式蒸发散的具体路线。

    CONTROLLING NANOBUBBLE AND NANOPARTICLE DYNAMICS IN CONICAL NANOPORES
    7.
    发明公开
    CONTROLLING NANOBUBBLE AND NANOPARTICLE DYNAMICS IN CONICAL NANOPORES 审中-公开
    控制和纳米颗粒NANOBLASEN - 动力学圆锥形纳米孔隙

    公开(公告)号：EP2986975A1

    公开(公告)日：2016-02-24

    申请号：EP14785203.2

    申请日：2014-04-17

    申请人： Revalesio Corporation

    发明人： GERMAN, Sean, R. ,  MEGA, Tony, L.

    IPC分类号： G01N27/26 ,  C12Q1/06 ,  B23P11/00

    CPC分类号： G01N33/48721

    摘要： Systems and methods for detect, manipulate and characterize nanobubbles and nanoparticles in solution. These comprise use of a conical-shaped nanopore having a nanoparticle or nanobubble sensing zone configured to be in communication with a saline solution, and having a half-cone angle sufficiently small to provide for significant channel-like character at the nanopore. An electrode(s) is used to apply a voltage/potential across the nanopore to provide electrophoretic force (EPF) across the nanopore, the nanopore is subjected to an electroosmotic force (EOF), pressure is applied/adjusted across the nanopore, and wherein adjusting at least one parameter selected from the group consisting of EPF, EOF, and pressure across the nanopore, provides for fine control of particle or nanobubble translocation velocities across the sensing zone of the nanopore (e.g., by shifting the zero velocity point to an applied voltage/potential to provide for an acceptable signal-to-noise ratio).

    BACTERIOSTATIC OR BACTERIOCIDAL COMPOSITIONS AND METHODS
    8.
    发明公开
    BACTERIOSTATIC OR BACTERIOCIDAL COMPOSITIONS AND METHODS 审中-公开
    抑菌或杀菌组合物和方法

    公开(公告)号：EP2207669A1

    公开(公告)日：2010-07-21

    申请号：EP08842668.9

    申请日：2008-10-23

    申请人： REVALESIO CORPORATION

    发明人： WATSON, Richard L. ,  WOOD, Anthony B. ,  ARCHAMBEAU, Gregory J.

    IPC分类号： B32B5/02 ,  B32B27/04

    CPC分类号： C12N13/00 ,  A61K33/00 ,  A61K45/06

    摘要： Particular aspects provide compositions and methods for treating or preventing bacterial infection or at least one symptom related to bacterial infection, and the like in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically generated fluid (including gas-enriched electrokinetically generated fluids) as disclosed herein, the electrokinetically altered aqueous fluid suitable to alter cellular membrane structure or function sufficient to provide for modulation of intracellular signal transduction, wherein treating bacterial infection or at least one symptom related to bacterial infection is thereby afforded. In particular embodiments, the fluids are gas-enriched fluids or therapeutic compositions and methods, and include oxygen-enriched water optionally in combination with other therapeutic agents. Other embodiments include particular routes of administration or formulations for the gas-enriched therapeutic compositions.

    COMPOSITIONS AND METHODS FOR TREATING MULTIPLE SCLEROSIS
    10.
    发明授权
    COMPOSITIONS AND METHODS FOR TREATING MULTIPLE SCLEROSIS 有权

    公开(公告)号：EP2282719B1

    公开(公告)日：2018-05-30

    申请号：EP09739530.5

    申请日：2009-04-27

    申请人： Revalesio Corporation

    发明人： WATSON, Richard, L. ,  WOOD, Anthony, B. ,  ARCHAMBEAU, Gregory, J.

    IPC分类号： A61K9/00 ,  A61K31/573 ,  A61K33/00

    CPC分类号： A61K31/573 ,  A61K33/00 ,  A61K2300/00

    摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating inflammatory neurodegenerative condition or disease or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.