公开(公告)号：EP3126845A1

公开(公告)日：2017-02-08

申请号：EP15717820.3

申请日：2015-03-31

申请人： Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts ,  Ruprecht-Karls-Universität Heidelberg Zentrale Universitätsverwaltung

发明人： FEDERICO, Giuseppina ,  PORUBSKY, Stefan ,  ARNOLD, Bernd ,  GRÖNE, Hermann-Josef ,  MEISTER, Michael

IPC分类号： G01N33/68 ,  A61P13/12

CPC分类号： G01N33/6893 ,  G01N2333/4703 ,  G01N2333/475 ,  G01N2500/00 ,  G01N2800/347 ,  G01N2800/52

摘要： The present invention relates to dkk3 as a marker for diagnosing chronic kidney disease and assessing the risk of disease progression, as well as to related methods and uses. In particular, the present invention relates to method for diagnosing chronic kidney disease, comprising the steps of a) obtaining a urine sample comprising early morning urine (EMU) from a mammalian, preferably a human, patient to be diagnosed, b) measuring the amount of Dickkopf 3 (DKK3) protein and/or adducts thereof in said sample, and c) concluding on a chronic kidney disease of said patient, wherein a higher amount of DKK3 protein and/or adducts thereof in said sample compared to a healthy patient is indicative for a chronic kidney disease.

摘要翻译： 本发明涉及dkk3作为诊断慢性肾脏疾病和评估疾病进展风险的标志物以及相关方法和用途。 特别地，本发明涉及用于诊断慢性肾脏疾病的方法，包括以下步骤：a）获得包含来自哺乳动物，优选人类待诊断的患者的清晨尿液（EMU）的尿液样本，b）测量所述量 所述样品中的Dickkopf 3（DKK3）蛋白质和/或其加合物，以及c）结论所述患者的慢性肾脏疾病，其中与健康患者相比，所述样品中较高量的DKK3蛋白质和/或其加合物与健康患者相比是 指示慢性肾脏疾病。