公开(公告)号：EP4263529A1

公开(公告)日：2023-10-25

申请号：EP21907266.7

申请日：2021-12-13

Applicant: ScinoPharm Taiwan, Ltd.

Inventor： HUANG, Kuan-Hsun ,  HUANG, Chung-Yang ,  HU, Tsung-Cheng

IPC: C07D403/04 ,  A61K31/506

公开(公告)号：EP4232433A1

公开(公告)日：2023-08-30

申请号：EP21883423.2

申请日：2021-03-26

Applicant: ScinoPharm Taiwan, Ltd.

Inventor： HUANG, Kuan-Hsun ,  WANG, Li-Ting ,  LIN, Inze ,  HU, Tsung-Cheng

IPC: C07D215/56 ,  A61K31/47

公开(公告)号：EP2477975B1

公开(公告)日：2018-01-10

申请号：EP10817525.8

申请日：2010-09-17

Applicant: ScinoPharm Taiwan Ltd.

Inventor： CHEN, Chen-Tung ,  LIN, Inze

IPC: C07D401/04 ,  A61P29/00 ,  A61P37/00 ,  A61K31/454 ,  A61P35/00

CPC classification number: C07D401/04

Abstract: The present invention provides for new crystalline and amorphous forms of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione, and methods of making the same.

公开(公告)号：EP3166918A1

公开(公告)日：2017-05-17

申请号：EP15819728.5

申请日：2015-07-09

Applicant: Scinopharm Taiwan, Ltd.

Inventor： HENSCHKE, Julian Paul ,  WU, Ping-yu ,  WU, Hsyueh-liang ,  WEN, Wen-hsien

IPC: C07C45/61 ,  C07C45/65 ,  C07C49/647 ,  C07C69/003

CPC classification number: C07F7/1892 ,  C07F5/025 ,  C07F7/1804

Abstract: This invention provides a novel method for the preparation of 2,3-disubstituted -4-oxy-cyclopentan1-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. The method comprises the metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted -4-oxy-cyclopent-2-en-1-ones. This method relies on the use of less toxic, easily-handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-1-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield.

Abstract translation: 本发明提供了一种新颖的方法，用于制备2,3-二取代的-4-氧基 - 环戊烷-1-酮的化合物是没有为前列腺素的合成和前列腺素产业关联的类似物是有用的。 该方法包括金属催化的不对称1,4-共轭加成乙烯基硼酸化合物的2- substituiertem -4-氧环戊-2-烯-1-酮。 此方法依赖于使用毒性较低，容易处理的试剂，并可以比一些常规方法提供的更温和的条件下进行，得到2,3-二取代的-4-氧基 - 环戊烷-1-酮的化合物和对映体非对映选择性 ，这是前体以高收率的所述前列腺素和前列腺素类似物。

公开(公告)号：EP3019861A4

公开(公告)日：2017-02-22

申请号：EP13888999

申请日：2013-07-11

Applicant: SCINOPHARM TAIWAN LTD

Inventor： CHAO HELEN ,  WANG CHUNGYAO ,  HUANG IMIN ,  WU CHIAYEN ,  CHIANG YUNGTE

IPC: G01N30/88 ,  B01D15/30 ,  C08B37/00 ,  G01N30/72

CPC classification number: G01N30/88 ,  B01D15/305 ,  C08B37/0078 ,  G01N30/7233 ,  G01N2030/8836

公开(公告)号：EP3080139A1

公开(公告)日：2016-10-19

申请号：EP13899097.3

申请日：2013-12-10

Applicant: Scinopharm Taiwan Ltd.

Inventor： ZHANG, Xiaoheng ,  MEI, Lijun

IPC: C07H19/167

CPC classification number: C07H19/16 ,  C07H19/167

Abstract: The present invention provides novel processes for the preparation of regadenoson having the formula (I). In some embodiments, the intermediates for the synthesis of regadenoson are also provided.

Abstract translation: 本发明提供了制备具有式（I）的regadenoson的新方法。 在一些实施方案中，还提供了用于合成regadenoson的中间体。

公开(公告)号：EP3024840A1

公开(公告)日：2016-06-01

申请号：EP13890122.8

申请日：2013-07-25

Applicant: Scinopharm Taiwan, Ltd.

Inventor： KUO, Lung-Huang ,  CHEN, Shang-Hong ,  WANG, Li-Ting ,  SHIH, Wen-Li ,  LIAO, Yuan-Xiu

IPC: C07H1/00 ,  A61K31/7024

Abstract: The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.

公开(公告)号：EP2753610A4

公开(公告)日：2015-11-04

申请号：EP12829246

申请日：2012-09-07

Applicant: SCINOPHARM TAIWAN LTD

Inventor： HSIAO TSUNGYU ,  HENSCHKE JULIAN PAUL ,  HO MENGFEN ,  HUANG YUANCHANG

IPC: C07D305/14 ,  A61K31/337 ,  A61P35/00

CPC classification number: C07D305/14 ,  A61K31/337

公开(公告)号：EP2768820A4

公开(公告)日：2015-03-25

申请号：EP12839769

申请日：2012-10-10

Applicant: SCINOPHARM TAIWAN LTD ,  SCINOPHARM SINGAPORE PTE LTD

Inventor： HSIAO TSUNG YU ,  TSENG HSINCHANG

IPC: C07D305/14 ,  A61K31/337 ,  A61P35/00

CPC classification number: C07D305/14

公开(公告)号：EP2753610A2

公开(公告)日：2014-07-16

申请号：EP12829246.3

申请日：2012-09-07

Applicant: Scinopharm Taiwan Ltd.

Inventor： HSIAO, Tsungyu ,  HENSCHKE, Julian, Paul ,  HO, Mengfen ,  HUANG, Yuanchang

IPC: C07D305/14 ,  A61K31/337 ,  A61P35/00

CPC classification number: C07D305/14 ,  A61K31/337

Abstract: , The present invention provides crystalline forms, including an anhydrate form, of cabazitaxel and processes for the preparation of these forms, designated as Forms C1, C2, C3, C4, C5, C6, C7, C8, C8b, C9 and C9p.