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1.发明授权PREPARATION AND USE OF FORMALIN-KILLED COLONIZATION-FACTOR-ANTIGEN (CFA)-EXPRESSING E. COLI ORGANISMS FOR VACCINATION AGAINST ENTERIC INFECTION/DIARRHEA CAUSED BY ENTEROTOXIGENIC E. COLI BACTERIA IN HUMANS 失效介绍和使用与甲醛杀死大肠杆菌的细胞集落因子抗原（CFA）EXPREMIEREN接种反对结肠感染/腹泻的人绊倒肠道细菌大肠杆菌
公开(公告)号：EP0573527B1
公开(公告)日：1998-09-09
申请号：EP92906078.8
申请日：1992-02-25
IPC分类号： A61K39/108
CPC分类号： A61K39/0258 , Y02A50/474 , Y10S435/849
摘要： Disclosed is a method of producing a vaccine composition against enteric infection caused by enterotoxigenic E. coli bacteria in humans. E. coli strains selected from different known strains each having the ability of expressing a certain type of colonization factor antigens are grown in a liquid culture medium. Finally formalin-killed E. coli strain having substantially preserved antigenic and hemagglutinating properties of said certain type of colonization factor antigens, is mixed with a pharmaceutically acceptable excipient and/or diluent. Further disclosed is a method of preventing an enteric infection caused by enterotoxigenic E. coli bacteria in humans, whereby a vaccine composition comprising inactivated E. coli strain is administered to a human being for the prevention of said infection.
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2.发明公开PREPARATION AND USE OF FORMALIN-KILLED COLONIZATION-FACTOR-ANTIGEN (CFA)-EXPRESSING E. COLI ORGANISMS FOR VACCINATION AGAINST ENTERIC INFECTION/DIARRHEA CAUSED BY ENTEROTOXIGENIC E. COLI BACTERIA IN HUMANS 失效介绍和使用与甲醛杀死大肠杆菌的细胞集落因子抗原（CFA）EXPREMIEREN接种反对结肠感染/腹泻的人绊倒的肠道细菌大肠杆菌。
公开(公告)号：EP0573527A1
公开(公告)日：1993-12-15
申请号：EP92906078.0
申请日：1992-02-25
CPC分类号： A61K39/0258 , Y02A50/474 , Y10S435/849
摘要： Disclosed is a method of producing a vaccine composition against enteric infection caused by enterotoxigenic E. coli bacteria in humans. E. coli strains selected from different known strains each having the ability of expressing a certain type of colonization factor antigens are grown in a liquid culture medium. Finally formalin-killed E. coli strain having substantially preserved antigenic and hemagglutinating properties of said certain type of colonization factor antigens, is mixed with a pharmaceutically acceptable excipient and/or diluent. Further disclosed is a method of preventing an enteric infection caused by enterotoxigenic E. coli bacteria in humans, whereby a vaccine composition comprising inactivated E. coli strain is administered to a human being for the prevention of said infection.
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