-
1.发明公开The use of a specific tumor associated antigen, sialosyllactotetraose, in diagnostic or therapeutic procedures related to cancer deseases 失效特异性肿瘤相关抗原，糖尿病视网膜病变与癌症病因相关的诊断或治疗方法的应用
公开(公告)号：EP0173663A3
公开(公告)日：1987-10-07
申请号：EP85850256
申请日：1985-08-06
发明人： Holmgren, Jan Roland
IPC分类号： G01N33/577 , G01N33/574 , A61K39/395 , A61K49/02 , C12P21/00 , C12N15/00 , C07H03/06
CPC分类号： C07K16/30 , A61K38/00 , A61K51/1045 , A61K2123/00
摘要： This invention relates to the use of a specific tumor associated antigen of carbohydrate nature, sialosyllactotetraose-(IV 3 NeuAcLcOs 4 ,) for diagnostic and therapeutic procedures related to human tumor diseases.
-
2.发明公开FUSION PROTEINS COMPRISING ANTIGENIC APOB-100 PROTEIN FRAGMENTS AND A PROTEIN CARRIER, RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR TREATMENT AND/OR PREVENTION OF ATHEROSCLEROSIS 有权与用于治疗和/或动脉粥样硬化预防抗原APOB 100蛋白质片段和蛋白质载体和相关组合物，方法和系统融合蛋白
公开(公告)号：EP2531524A1
公开(公告)日：2012-12-12
申请号：EP11702831.6
申请日：2011-02-07
申请人： Nilsson, Jan , Hansson, Göran K. , Holmgren, Jan
发明人： Nilsson, Jan , Hansson, Göran K. , Holmgren, Jan
IPC分类号： C07K14/775 , C07K19/00 , A61K38/17
CPC分类号： C07K14/775 , C07K14/195 , C07K2319/31 , C07K2319/55
摘要： A fusion protein comprising an antigenic fragment of apoB-100 and a suitable carrier and related compositions methods and systems.
-
3.发明授权PREPARATION AND USE OF FORMALIN-KILLED COLONIZATION-FACTOR-ANTIGEN (CFA)-EXPRESSING E. COLI ORGANISMS FOR VACCINATION AGAINST ENTERIC INFECTION/DIARRHEA CAUSED BY ENTEROTOXIGENIC E. COLI BACTERIA IN HUMANS 失效介绍和使用与甲醛杀死大肠杆菌的细胞集落因子抗原（CFA）EXPREMIEREN接种反对结肠感染/腹泻的人绊倒肠道细菌大肠杆菌
公开(公告)号：EP0573527B1
公开(公告)日：1998-09-09
申请号：EP92906078.8
申请日：1992-02-25
IPC分类号： A61K39/108
CPC分类号： A61K39/0258 , Y02A50/474 , Y10S435/849
摘要： Disclosed is a method of producing a vaccine composition against enteric infection caused by enterotoxigenic E. coli bacteria in humans. E. coli strains selected from different known strains each having the ability of expressing a certain type of colonization factor antigens are grown in a liquid culture medium. Finally formalin-killed E. coli strain having substantially preserved antigenic and hemagglutinating properties of said certain type of colonization factor antigens, is mixed with a pharmaceutically acceptable excipient and/or diluent. Further disclosed is a method of preventing an enteric infection caused by enterotoxigenic E. coli bacteria in humans, whereby a vaccine composition comprising inactivated E. coli strain is administered to a human being for the prevention of said infection.
-
4.发明公开HYBRID MOLECULES BETWEEN HEAT-LABILE ENTEROTOXIN AND CHOLERA TOXIN B SUBUNITS 失效杂交分子从以单位不耐热肠毒素和霍乱毒素B
公开(公告)号：EP0824548A1
公开(公告)日：1998-02-25
申请号：EP96915275.0
申请日：1996-05-02
CPC分类号： C07K14/28 , A61K39/00 , C07K14/245 , C07K2319/00 , Y02A50/472
摘要： PCT No. PCT/SE96/00570 Sec. 371 Date Jan. 5, 1998 Sec. 102(e) Date Jan. 5, 1998 PCT Filed May 2, 1996 PCT Pub. No. WO96/34893 PCT Pub. Date Nov. 7, 1996Hybrid molecules between heat-labile enterotoxin B subunit (LTB) and cholera toxin B subunit (CTB) are disclosed. Such a hybrid molecule comprises an amino-acid sequence which is composed of the amino-acid sequence of mature CTB in which such amino-acid residues are substituted with the corresponding amino-acid residues of mature LTB which impart LTB-specific epitope characteristics to said immunogenic mature CTB, or vice versa. In addition, a structural gene coding for such a hybrid molecule, a plasmid containing such a structural gene, and an immunogenic protein comprising such a hybrid molecule and optionally an immunoreactive amino-acid sequence of a prokaryotic or eukaryotic cell or a virus, are disclosed. Disclosed is also a vaccine, e.g. against enterotoxin-induced illness, comprising such an immunogenic protein, and a method of preventing or treating enterotoxin-induced illness in an individual.
-
5.发明公开PREPARATION AND USE OF FORMALIN-KILLED COLONIZATION-FACTOR-ANTIGEN (CFA)-EXPRESSING E. COLI ORGANISMS FOR VACCINATION AGAINST ENTERIC INFECTION/DIARRHEA CAUSED BY ENTEROTOXIGENIC E. COLI BACTERIA IN HUMANS 失效介绍和使用与甲醛杀死大肠杆菌的细胞集落因子抗原（CFA）EXPREMIEREN接种反对结肠感染/腹泻的人绊倒的肠道细菌大肠杆菌。
公开(公告)号：EP0573527A1
公开(公告)日：1993-12-15
申请号：EP92906078.0
申请日：1992-02-25
CPC分类号： A61K39/0258 , Y02A50/474 , Y10S435/849
摘要： Disclosed is a method of producing a vaccine composition against enteric infection caused by enterotoxigenic E. coli bacteria in humans. E. coli strains selected from different known strains each having the ability of expressing a certain type of colonization factor antigens are grown in a liquid culture medium. Finally formalin-killed E. coli strain having substantially preserved antigenic and hemagglutinating properties of said certain type of colonization factor antigens, is mixed with a pharmaceutically acceptable excipient and/or diluent. Further disclosed is a method of preventing an enteric infection caused by enterotoxigenic E. coli bacteria in humans, whereby a vaccine composition comprising inactivated E. coli strain is administered to a human being for the prevention of said infection.
-
6.发明公开The use of a specific carcinom associated antigen (hapten), fucosylsialosylgangliotetraose (Fuc-GM1) in diagnostic or therapeutic procedures related to human lung cancer (small cell carcinomas) 失效特异性相关抗原（HAPTEN），FUCOSYLSIALOSYLGANGLIOTETRAOSE（FUC-GM1）在人肺癌（小细胞肺癌）相关诊断或治疗方案中的应用
公开(公告)号：EP0162825A3
公开(公告)日：1987-10-07
申请号：EP85850172
申请日：1985-05-15
发明人： Holmgren, Jan Roland
IPC分类号： A61K39/385 , C12N15/00 , C12P21/00 , C12N05/00 , A61K49/02 , G01N33/531 , G01N33/543 , G01N33/577 , G01N33/574 , C12R01/91
CPC分类号： A61K51/0491 , A61K39/00 , A61K39/0011 , A61K51/1045 , A61K51/1081 , A61K2039/521 , A61K2039/6006 , A61K2039/622 , A61K2123/00 , C07K16/30 , C07K16/44 , G01N33/531 , Y10S435/96 , Y10S436/813
摘要： This invention relates to the use of a specific carcinoma associated antigen/hapten of carbohydrate nature, fucosylsialosylgangliotetraose-IV 2 αFucll 3 -αNeuAcGgOse 4 -(IUPAC-IUB Lipid Document, 1977) for diagnostic and therapeutic procedures related to human lung cancer (small cell carcinomas).
-
7.发明授权HYBRID MOLECULES BETWEEN HEAT-LABILE ENTEROTOXIN AND CHOLERA TOXIN B SUBUNITS 失效杂交分子从以单位不耐热肠毒素和霍乱毒素B
公开(公告)号：EP0824548B1
公开(公告)日：2004-12-08
申请号：EP96915275.0
申请日：1996-05-02
IPC分类号： C07K19/00 , C07K14/28 , C07K14/245 , C12N15/62 , A61K39/116
CPC分类号： C07K14/28 , A61K39/00 , C07K14/245 , C07K2319/00 , Y02A50/472
摘要： PCT No. PCT/SE96/00570 Sec. 371 Date Jan. 5, 1998 Sec. 102(e) Date Jan. 5, 1998 PCT Filed May 2, 1996 PCT Pub. No. WO96/34893 PCT Pub. Date Nov. 7, 1996Hybrid molecules between heat-labile enterotoxin B subunit (LTB) and cholera toxin B subunit (CTB) are disclosed. Such a hybrid molecule comprises an amino-acid sequence which is composed of the amino-acid sequence of mature CTB in which such amino-acid residues are substituted with the corresponding amino-acid residues of mature LTB which impart LTB-specific epitope characteristics to said immunogenic mature CTB, or vice versa. In addition, a structural gene coding for such a hybrid molecule, a plasmid containing such a structural gene, and an immunogenic protein comprising such a hybrid molecule and optionally an immunoreactive amino-acid sequence of a prokaryotic or eukaryotic cell or a virus, are disclosed. Disclosed is also a vaccine, e.g. against enterotoxin-induced illness, comprising such an immunogenic protein, and a method of preventing or treating enterotoxin-induced illness in an individual.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.011 秒)
