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    A MULTI COMPONENT CONTROLLED DELIVERY SYSTEM FOR FABRIC CARE PRODUCTS
    2.
    发明公开
    A MULTI COMPONENT CONTROLLED DELIVERY SYSTEM FOR FABRIC CARE PRODUCTS 审中-公开
    多组分体系，为纺织护理产品的控制分布

    公开(公告)号：EP1499704A4

    公开(公告)日：2005-12-07

    申请号：EP03714246

    申请日：2003-03-19

    申请人： SALVONA LLC

    发明人： SHEFER ADI ,  SHEFER SAMUEL

    IPC分类号： C11D1/62 ,  C11D3/37 ,  C11D3/38 ,  C11D3/395 ,  C11D3/48 ,  C11D3/50 ,  C11D9/00 ,  C11D9/26 ,  C11D9/36 ,  C11D17/00 ,  D06M13/463 ,  D06M13/473

    CPC分类号： C11D17/0039 ,  C11D1/62 ,  C11D3/505 ,  C11D9/00 ,  C11D9/26 ,  C11D9/36

    摘要： The present invention relates to an improved controlled delivery system that can be incorporated in dry granular, or powder, fabric care products, such as laundry detergents, tumble dryer sheets, rinse added products, and other fabric care products, to enhance fragrance performance. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nano-spheres of encapsulated active ingredients, such as a fragrance, that are encapsulated in a moisture sensitive micro-spheres, solid spheres. The high cationic charge density of the nano-sphere improves fragrance deposition onto the laundered fabric. The high cationic charge density on the nano-sphere surface is created by incorporating a cationic fabric conditioning agent into the solid hydrophobic matrix of the nano-spheres, by incorporating a cationic charge "booster" in the water sensitive micro-sphere matrix, or by using a cationic fabric conditioning agent in the nano-sphere matrix in conjunction with a cationic charge "booster" in the micro-sphere matrix. The fragrance carrier system also provides controlled release or prolonged fragrance release from the dry laundered fabric over an extended period of time, or yields a high impact fragrance "burst" upon ironing the fabric. The invention also pertains to fabric care products comprising the controlled release system of the present invention.

    ORAL CONTROLLED RELEASE SYSTEM FOR TARGETED DRUG DELIVERY INTO THE CELL AND ITS NUCLEUS FOR GENE THERAPY, DNA VACCINATION AND ADMINISTRATION OF GENE BASED DRUGS
    7.
    发明公开
    ORAL CONTROLLED RELEASE SYSTEM FOR TARGETED DRUG DELIVERY INTO THE CELL AND ITS NUCLEUS FOR GENE THERAPY, DNA VACCINATION AND ADMINISTRATION OF GENE BASED DRUGS 审中-公开
    口服控释系统进行有针对性的药物供应在细胞及其核心基因治疗，DNA疫苗和给药药物基因为基础的

    公开(公告)号：EP1720522A1

    公开(公告)日：2006-11-15

    申请号：EP05729926.5

    申请日：2005-03-02

    申请人： Salvona LLC

    发明人： SHEFER, Adi ,  SHEFER, Samuel

    IPC分类号： A61K9/14 ,  A61K9/50 ,  A61K9/51 ,  A61K9/52 ,  A61K9/56 ,  A61K9/58 ,  A61K9/62 ,  A61K9/127

    CPC分类号： A61K9/5123 ,  A61K9/1635 ,  A61K48/0008 ,  A61K48/0075 ,  B82Y5/00

    摘要： The present invention relates to an oral drug delivery system which delivers pharmaceutical active ingredients into the cell and/or its nucleus for the effective administration of nucleic acids including gene therapy, vaccination, administration of gene based drugs or administration of gene based treatment modalities, including the use of sense, antisense nucleotide sequences, antigens, antibodies, ribozymes, as well as oligonucleotides and polynucleotide constructs for gene correction. These actives may also include viruses, vectors, proteins, peptides, and nucleic acids, DNA or RN fragments, which code functionally active or inactive or conditionally inactivatable proteins. The controlled delivery system of the present invention is substantially a free-flowing powder consisting of solid hydrophobic nanospheres encapsulated in pH sensitive microspheres. The controlled release system can be used to target and control the release of pharmaceutical active ingredients onto certain regions of the gastrointestinal tract, specially the small intestine. The invention further pertains to pharmaceutical products comprising the controlled release system of the present invention.