摘要:
Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.
摘要:
An edible composition of matter having an apparent viscosity of from about 150 cP to about 2000 cP at about 30 s-1; a yield stress of from 0 Pa to about 20 Pa at 1 s-1; and a flow index of from about 0.2 to about 0.6. The composition may include an imaging agent. The compositions are useful for providing sustenance to dysphagic subjects and for evalualuating dysphagia.
摘要:
The subject invention provides an X-ray visible drug delivery device for subdermal administration of a contraceptive or hormone remplacement therapy.
摘要:
The subject invention provides an X-ray visible drug delivery device for subdermal administration of a contraceptive or hormone remplacement therapy.
摘要:
This invention relates to a colonic residue tagging system, formulation, it and method for use in preparing an individual for a predetermined activity which requires tagging at least some colonic residue in a digestive tract such that a medically and/or diagnostically useful procedure can be performed on the difestive tract. Such predetermined activity includes, but is not limited to, colon screening. In one alternative embodiment, a dietary regimen comprising low residue food is coordinated with the colonic residue tagging regimen, prior to a predetermined activity, thereby resulting in tagged stool such that a medically or diagnostically useful procedure can be performed on the digestive tract. The present invention also provides an individual sufficient amounts of fluids and nutrition while minimizing the amount of stool formation prior to the predetermined activity.
摘要:
Disclosed are a viscosity-standardized combination of solutions and a method of using the solutions for the diagnosis of dysphagia and for radiographic imaging of the oropharynx. This invention is directed to a standardized combination of edible solutions for evaluating human subjects for the presence of dyshagia. Because the solutions have a standard and known viscosity, they promote the systematic study and treatment of swallowing disorders. The combination comprises three solutions: the first a 'thin' composition, the second a 'nectar thick' composition and the third a 'honey thick' composition. The utilities of the subject compositions and methods are several-fold. A primary utility is that by using standardized compositions, consistency in treating dysphagia is promoted. Rather than supplying patients an arbitrarily thickened food or X-ray imaging product, the patient is supplied a composition of known viscosity. The patient's ability to swallow the composition properly i studies (one using the nectar-thick composition, the other using the honey-thick composition) to be compared and contrasted. Moreover, it allows the results from different patients to be compared directly, without variations in viscosity of the imaging agent introducing uncontrolled variables into the comparison.
摘要:
Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise an ethylene vinyl alcohol copolymer, a biocompatible solvent and a water insoluble contrasting agent selected from the group consisting of tantalum, tantalum oxide and barium sulfate. Also disclosed are methods for embolizing a blood vessel using the compositions described herein.
or a pharmaceutically acceptable salt thereof, contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein X= or ―SO₂―; Z= H, halo, C₁-C₂₀ alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R= C₁-C₂₅ alkyl, cycloalkyl, aryl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene, lower-alkoxy-carbonyloxy; n = 1-5; y = 0-4; and w = 1-4.
摘要翻译:本发明公开了含水组合物中含有的式“IMAGE”的造影剂及其用于胃肠道诊断放射学的方法,其中X = Z,H,卤素,C 1 -C 20烷基,环烷基,低级烷氧基,氰基, 其中烷基和环烷基可被卤素或卤代低级烷基取代; R = C 1 -C 25烷基,环烷基,芳基或卤代低级烷基,任选被卤素,氟代低级烷基,低级烷氧基,羟基,羧基或低级烷氧基羰基,低级烯基,低级 - 炔基, 低级亚烷基,低级烷氧基 - 羰氧基; N = 1-5; Y = 0-4; 并且在药学上可接受的载体中w = 1-4。
摘要:
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract , in combination with a divalent cation and an x-ray contrast producing agent of the formula
or a pharmaceutically acceptable salt thereof, and methods for their use in diagnostic radiology of the gastrointestinal tract wherein
Z = H, halo, C 1 -C 20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R 1 and R 2 are independently C l -C 25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxycarbonyloxy; n is 1-5; y is 1-4; and x is 1 or 2