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公开(公告)号：EP0260635A2
公开(公告)日：1988-03-23
申请号：EP87113397.1
申请日：1987-09-14
申请人： Sepragen Corporation
CPC分类号： H01J49/0431 , G01N27/44717 , Y10T436/24
摘要： The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface,which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation,and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface.
摘要翻译： 本发明涉及用于分离化合物的复杂混合物的新技术，其利用用于常规质谱仪的独特界面探针，其允许通过质谱仪实时分析电泳分离的化合物。 这种将质谱耦合电泳的新化学分析界面允许复杂的混合物被快速分析，具有更大的特异性和更高的灵敏度。 界面或探针提供了使复杂混合物中的大分子和/或极性分子完全表征的方法。 探针的优选实施例使用双毛细管尖端，其允许探针尖端被缓冲器连续地润湿，这提供了增加的散热，并且导致连续操作界面，其比所示的单个毛细管更耐用和电子稳定 尖端探针接口。
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公开(公告)号：EP1017286A1
公开(公告)日：2000-07-12
申请号：EP97944384.3
申请日：1997-09-22
申请人： Sepragen Corporation
IPC分类号： A23C9/14
CPC分类号： A23C9/1465 , A23C11/04 , A23J1/205
摘要： A method is disclosed for sequential separation of whey proteins using radial-flow chromatography. Different buffer systems adjusted to suitable pH and ionic strength are utilized in the separation process. The method separates at least five different proteins from whey. Infant feeding formulas, and other food formulations are also disclosed incorporating therein in different proportions various proteins separated from the whey.
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公开(公告)号：EP0260635B1
公开(公告)日：1994-03-02
申请号：EP87113397.1
申请日：1987-09-14
申请人： Sepragen Corporation
CPC分类号： H01J49/0431 , G01N27/44717 , Y10T436/24
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公开(公告)号：EP0260635A3
公开(公告)日：1989-08-23
申请号：EP87113397.1
申请日：1987-09-14
申请人： Sepragen Corporation
CPC分类号： H01J49/0431 , G01N27/44717 , Y10T436/24
摘要： The invention involves a new technique for the separation of complex mixtures of chemicals, which utilizes a unique interface probe for conventional mass spectrometers which allows the electrophoretically separated compounds to be analyzed in real-time by a mass spectrometer. This new chemical analysis interface,which couples electrophoresis with mass spectrometry, allows complex mixtures to be analyzed very rapidly, with much greater specificity, and with greater sensitivity. The interface or probe provides a means whereby large and/or polar molecules in complex mixtures to be completely characterized. The preferred embodiment of the probe utilizes a double capillary tip which allows the probe tip to be continually wetted by the buffer, which provides for increased heat dissipation,and results in a continually operating interface which is more durable and electronically stable than the illustrated single capillary tip probe interface.
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公开(公告)号：EP0259796B1
公开(公告)日：1996-01-03
申请号：EP87112952.4
申请日：1987-09-04
申请人： Sepragen Corporation
IPC分类号： H01J49/04
CPC分类号： H01J49/0431 , G01N30/7286 , H01J49/049
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公开(公告)号：EP0530258B1
公开(公告)日：1995-09-20
申请号：EP91909759.2
申请日：1991-05-22
申请人： Sepragen Corporation
CPC分类号： B01J39/22 , B01D15/00 , B01D15/08 , B01D15/361 , B01D15/3804 , B01J20/26 , G01N2030/528
摘要： A cross-linked flexible sponge adsorbent medium containing substantially uniformly distributed fibrous reinforcement is prepared under such conditions that swelling of the sponge is controlled to a water retention value of 2 to 6; and simultaneously or subsequently, the cross-linked sponge is reacted with a reagent which introduces functional groups into the modified cross-linked sponge. There is also provided apparatus having an inlet for liquid, an outlet for liquid so as to define a path for liquid flow between the inlet and the outlet, an adsorbent medium, obtainable by the above method, being positioned across the liquid flow path in the apparatus.
摘要翻译： 含有基本上均匀分布的纤维增强材料的交联柔性海绵吸附介质在这样的条件下制备，即海绵的膨胀控制在2至6的保水值; 同时或随后，使交联海绵与将官能团引入改性交联海绵的试剂反应。 还提供了具有液体入口，液体出口以限定入口和出口之间的液体流动路径的设备，通过上述方法可获得的吸附介质定位在液体流动路径中的 仪器。
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公开(公告)号：EP0259796A3
公开(公告)日：1989-10-18
申请号：EP87112952.4
申请日：1987-09-04
申请人： Sepragen Corporation
CPC分类号： H01J49/0431 , G01N30/7286 , H01J49/049
摘要： A moving belt interface for real-time, high-performance liquid chromatograph (HPLC)/mass spectrometer (MS) analysis which strips away the HPLC solvent as it emerges from the end of the HPLC column and leaves a residue suitable for mass-spectral analysis. The interface includes a portable, stand-alone apparatus having a plural stage vacuum station, a continuous ribbon or belt, a drive train magnetically coupled to an external drive motor, a calibrated HPLC delivery system, a heated probe tip and means located adjacent the probe tip for direct ionization of the residue on the belt. The interface is also capable of being readily adapted to fit any mass spectrometer.
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公开(公告)号：EP0259796A2
公开(公告)日：1988-03-16
申请号：EP87112952.4
申请日：1987-09-04
申请人： Sepragen Corporation
CPC分类号： H01J49/0431 , G01N30/7286 , H01J49/049
摘要： A moving belt interface for real-time, high-performance liquid chromatograph (HPLC)/mass spectrometer (MS) analysis which strips away the HPLC solvent as it emerges from the end of the HPLC column and leaves a residue suitable for mass-spectral analysis. The interface includes a portable, stand-alone apparatus having a plural stage vacuum station, a continuous ribbon or belt, a drive train magnetically coupled to an external drive motor, a calibrated HPLC delivery system, a heated probe tip and means located adjacent the probe tip for direct ionization of the residue on the belt. The interface is also capable of being readily adapted to fit any mass spectrometer.
摘要翻译： 用于实时，高效液相色谱（HPLC）/质谱仪（MS）分析的移动带接口，从HPLC柱的末端离开HPLC溶剂，并留下适合于质谱分析的残留物 。 该接口包括具有多级真空站，连续带或带的便携式独立设备，磁耦合到外部驱动马达的驱动系，校准的HPLC输送系统，加热的探针尖端和位于探头附近的装置 尖端用于直接电离皮带上的残留物。 该界面还能够容易地适应于任何质谱仪。
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