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    DETECTION OF A TARGET IN A SAMPLE
    2.
    发明授权
    DETECTION OF A TARGET IN A SAMPLE 有权
    NACHWEIS EINER ZIELSUBSTANZ IN EINER PROBE

    公开(公告)号：EP1075656B1

    公开(公告)日：2011-07-06

    申请号：EP99918252.0

    申请日：1999-05-04

    申请人： Technion Research & Development Foundation Limited ,  Eichen, Yoav ,  Sivan, Uri ,  Braun, Erez

    发明人： EICHEN, Yoav ,  SIVAN, Uri ,  BRAUN, Erez

    IPC分类号： G01N27/327 ,  G01N33/543 ,  G01N27/00 ,  C12Q1/68

    CPC分类号： C12Q1/6825 ,  C12Q1/6816 ,  C12Q1/6834 ,  G01N33/5438

    摘要： The invention concerns a system, device, kit and method for detecting the presence, or concentration of a target in a sample. An assay set comprising at least two spaced apart electrodes is used, comprising a recognition moiety, capable of specific binding to the target, which is attached to at least one of the electrodes or the substrate therein between. If the recognition moiety binds the target then a conductive bridge can be formed between the electrodes, based on the complex between the recognition moiety and the target. The conductive bridge is formed by using nucleation-center forming entities attached to the complexes or to the targets from which a conductive substance is substantially grown. Alternatively the conducting bridge forms a conductive polymer between the electrodes.

    摘要翻译： 本发明涉及用于检测样品中靶的存在或浓度的系统，装置，试剂盒和方法。 使用包含至少两个间隔开的电极的测定组，其包含能够特异性结合靶的识别部分，其连接到至少一个电极或其中的基板之间。 如果识别部分结合靶，则可以基于识别部分和靶之间的复合物在电极之间形成导电桥。 导电桥是通过使用连接到复合物或基本上生长导电物质的靶的成核中心形成实体形成的。 或者，导电桥在电极之间形成导电聚合物。