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1.发明公开ABSORBENT POLYMERIC COMPOSITIONS WITH VARYING COUNTERION CONTENT AND THEIR METHODS OF PREPARATION AND USE 有权具有不同针对离子含量吸水树脂组合物及其制造和使用方法
公开(公告)号：EP2187979A1
公开(公告)日：2010-05-26
申请号：EP08798991.9
申请日：2008-08-29
发明人： STRICKLAND, Alan , GRASS, George
CPC分类号： C08F2/32 , A61K9/1688 , A61K9/4891 , A61K31/78 , C08F220/06 , C08F222/1006 , C08J3/12 , C08J3/128 , C08J2300/14 , C08J2333/08
摘要： Cross-linked polyelectrolyte polymers with bound counterions that absorb about 20-fold or more of their mass in saline such as physiological saline a with the proviso that sodium does not exceed 60% of total bound counterions when hydrogen is the sole other counterion, are disclosed. Methods of preparing the disclosed polymers and for treating subjects such as patients in need of fluid removal and/or modulation of ions (e.g., sodium and/or potassium) are provided.
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2.发明公开Water-absorbent polymers and their use as a medicament 审中-公开Wasser-absorptionierende Polymere und ihre Verwendung als Arzneimittel
公开(公告)号：EP1847271A2
公开(公告)日：2007-10-24
申请号：EP07015451.3
申请日：2001-11-06
发明人： Simon, Jaime , Strickland, Alan D.
IPC分类号： A61K31/715 , A61K9/16 , A61K9/50 , A61P7/10 , A61K47/30 , A61K47/38 , A61P7/00 , A61K31/78 , A61K31/74 , A61K47/32
CPC分类号： A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/74 , A61K31/78 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
摘要翻译： 本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。 在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。 聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。 优选的聚合物包括优选以珠粒形式提供的超级吸收性丙烯酸聚合物。 聚合物可以包括用于选择性除去血液传播的废物的官能团，例如， 尿素，来自G.I. 道。
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3.发明公开COMPOSITIONS COMPRISING CROSSLINKED CATION- BINDING POLYMERS AND CALCIUM AND/OR MAGNESIUM CATIONS, AND USES THEREOF 审中-公开组合物的交联阳离子结合聚合物以及钙和/或镁离子和它们的用途
公开(公告)号：EP2663291A1
公开(公告)日：2013-11-20
申请号：EP12701299.5
申请日：2012-01-10
IPC分类号： A61K9/16
CPC分类号： A61K31/78 , A23L33/10 , A61K9/1611 , A61K9/1635
摘要： The present disclosure relates generally to use of crosslinked cation-binding polymers containing carboxylic acid groups for treatment of heart failure and associated symptoms and conditions. In particular, the disclosed polymers, and compositions, formulations, and dosage forms containing the polymers, may be used to treat ion and/or fluid imbalances associated with heart failure.
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4.发明公开Absorbent polymeric compositions with varying counterion content and their methods of preparation and use 审中-公开具有不同抗衡离子含量的吸收性聚合物组合物及其制备和使用方法
公开(公告)号：EP2583698A1
公开(公告)日：2013-04-24
申请号：EP12194070.4
申请日：2008-08-29
发明人： Strickland, Alan , Grass, George
CPC分类号： C08F2/32 , A61K9/1688 , A61K9/4891 , A61K31/78 , C08F220/06 , C08F222/1006 , C08J3/12 , C08J3/128 , C08J2300/14 , C08J2333/08
摘要： Cross-linked polyelectrolyte polymers with bound counterions that absorb about 20-fold or more of their mass in saline such as physiological saline a with the proviso that sodium does not exceed 60% of total bound counterions when hydrogen is the sole other counterion, are disclosed. Methods of preparing the disclosed polymers and for treating subjects such as patients in need of fluid removal and/or modulation of ions (e.g., sodium and/or potassium) are provided.
摘要翻译： 具有结合抗衡离子的交联聚电解质聚合物被公开，所述抗衡离子在盐水中吸收其质量的约20倍或更多，例如生理盐水，条件是当氢是唯一的其他抗衡离子时钠不超过总结合反离子的60％ 。 提供制备所公开的聚合物和用于治疗诸如需要流体去除和/或离子调节（例如钠和/或钾）的患者的受试者的方法。
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5.发明授权ABSORBENT POLYMERIC COMPOSITIONS WITH VARYING COUNTERION CONTENT AND THEIR METHODS OF PREPARATION AND USE 有权具有不同针对离子含量吸水树脂组合物及其制造和使用方法
公开(公告)号：EP2187979B1
公开(公告)日：2014-09-24
申请号：EP08798991.9
申请日：2008-08-29
发明人： STRICKLAND, Alan , GRASS, George
CPC分类号： C08F2/32 , A61K9/1688 , A61K9/4891 , A61K31/78 , C08F220/06 , C08F222/1006 , C08J3/12 , C08J3/128 , C08J2300/14 , C08J2333/08
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公开(公告)号：EP1381376B1
公开(公告)日：2008-01-02
申请号：EP01992473.7
申请日：2001-11-06
发明人： SIMON, Jaime , STRICKLAND, Alan, D.
IPC分类号： A61K31/715 , A61K9/16 , A61K9/50 , A61P7/10
CPC分类号： A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K31/78 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patents suffering from fluid overload states. In one embodiment, the subject method involves ingesting and entericaally coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polmers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, for the G.I. tract.
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7.发明公开COMPOSITIONS COMPRISING CROSSLINKED CATION- BINDING POLYMERS AND A BASE, USES THEREOF 审中-公开组合物的交联阳离子结合聚合物和碱及其用途
公开(公告)号：EP2663290A1
公开(公告)日：2013-11-20
申请号：EP12701298.7
申请日：2012-01-10
CPC分类号： A61K31/78 , A23L33/10 , A61K9/1611 , A61K9/1635
摘要： The present disclosure relates generally to use of crosslinked cation-binding polymers containing carboxylic acid groups for treatment of heart failure and associated symptoms and conditions. In particular, the disclosed polymers, and compositions, formulations, and dosage forms containing the polymers, may be used to treat ion and/or fluid imbalances associated with heart failure.
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8.发明公开Absorbent polymeric compositions with varying counterion content and their methods of preparation and use 审中-公开与使用不同的反离子含量及其生产方法和吸收性聚合物组合物
公开(公告)号：EP2601981A1
公开(公告)日：2013-06-12
申请号：EP12194076.1
申请日：2008-08-29
发明人： Strickland, Alan , Grass, George
IPC分类号： A61L15/60 , C08F8/00 , C08F20/00 , A61K9/16 , A61K31/78 , C08J3/12 , C08F220/06 , A61K9/48 , C08F222/10
CPC分类号： C08F2/32 , A61K9/1688 , A61K9/4891 , A61K31/78 , C08F220/06 , C08F222/1006 , C08J3/12 , C08J3/128 , C08J2300/14 , C08J2333/08
摘要： Cross-linked polyelectrolyte polymers with bound counterions that absorb about 20-fold or more of their mass in saline such as physiological saline a with the proviso that sodium does not exceed 60% of total bound counterions when hydrogen is the sole other counterion, are disclosed. Methods of preparing the disclosed polymers and for treating subjects such as patients in need of fluid removal and/or modulation of ions (e.g., sodium and/or potassium) are provided.
摘要翻译： 具有结合的抗衡离子交联聚电解质的聚合物并吸收约20倍或在盐水中更多的质量：如生理盐水，条件做的钠大小限制总结合的抗衡离子的60％。当氢是唯一的其它抗衡离子，是圆盘游离缺失 ， 制备游离缺失盘聚合物和用于治疗受试者的方法：如有需要的病人流体去除和/或离子（例如，钠和/或钾）的调制的被提供。
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公开(公告)号：EP2324861A1
公开(公告)日：2011-05-25
申请号：EP10012216.7
申请日：2001-11-06
发明人： Simon, Jaime , Strickland, Alan D.
IPC分类号： A61L15/60
CPC分类号： A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K31/78 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
摘要翻译： 本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。 在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。 聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。 优选的聚合物包括优选以珠粒形式提供的超级吸收性丙烯酸聚合物。 聚合物可以包括用于选择性除去血液传播的废物的官能团，例如， 尿素，来自G.I. 道。
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公开(公告)号：EP1847271A3
公开(公告)日：2008-08-06
申请号：EP07015451.3
申请日：2001-11-06
发明人： Simon, Jaime , Strickland, Alan D.
IPC分类号： A61K31/715 , A61K9/16 , A61K9/50 , A61P7/10 , A61K47/30 , A61K47/38 , A61P7/00 , A61K31/78 , A61K31/74 , A61K47/32
CPC分类号： A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/74 , A61K31/78 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
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