公开(公告)号：EP3407915A1

公开(公告)日：2018-12-05

申请号：EP17744768.7

申请日：2017-01-24

申请人： President and Fellows of Harvard College ,  Children's Medical Center Corporation ,  McCarroll, Steven A. ,  Sekar, Aswin ,  Carroll, Michael C. ,  Stevens, Beth

发明人： MCCARROLL, Steven, A. ,  SEKAR, Aswin ,  CARROLL, Michael, C. ,  STEVENS, Beth

IPC分类号： A61K45/00 ,  A61P25/18 ,  C07K16/18

CPC分类号： A61K45/00 ,  A61K48/005 ,  C07K14/005 ,  C07K14/472 ,  C12N2740/10022 ,  G01N33/6896 ,  G01N2800/302

摘要： The invention provides methods of treating schizophrenia in a subject, including for example, administering to the subject an agent that inhibits expression or activity of a C4A polynucleotide or polypeptide. The invention also provides methods of identifying a subject having or at risk of developing schizophrenia involving measuring or detecting an alteration in the level, copy number, and/or sequence of complement component C4A or complement component C4B relative to a reference.