公开(公告)号：EP3782995A1

公开(公告)日：2021-02-24

申请号：EP19788657.5

申请日：2019-04-18

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Suzhou Institute of Drug Innovation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： ZHOU, Bing ,  LUO, Cheng ,  JIANG, Hualiang ,  YANG, Yaxi ,  MEI, Lianghe ,  LU, Wenchao ,  XIAO, Senhao ,  CHEN, Shijie ,  WAN, Shili ,  QIAO, Gang ,  ZHANG, Rukang

IPC分类号： C07D413/06 ,  C07D417/06 ,  C07D413/14 ,  A61K31/4725 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554 ,  A61K31/5513 ,  A61P35/00 ,  A61P35/02 ,  A61P3/00 ,  A61P25/28 ,  A61P29/00

摘要： The present invention relates to a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the treatment of various HAT-related diseases or conditions.