Abstract:
A system (Fig 8) for conducting high-temperature liquid chromatographic analysis includes a mobile phase transport tube (202) configured to operably convey mobile phase from a source to respective chromatographic instruments (206) in the system, a pre-heater (212) apparatus operably coupled to the mobile phase transport tube for heating the mobile phase to a desired temperature, a chromatographic column (206) operably coupled to the pre-heater apparatus, and including temperature-maintaining means (204) for maintaining the column at a pre-determined temperature and a counter-flow heat exchanger (212) operably exchanging heat from outlet mobile phase to inlet mobile phase trough conductive heat transfer means. In a particular embodiment, the mobile phase passing through the chromatographic column is maintained in a substantially adiabatic environment.
Abstract:
A flow-dampening degassing apparatus for transport of liquid chromatography fluids therethrough includes a substantially burdoin-shaped flexible tube disposed in a reduced-pressure chamber, the tube being sufficiently flexible to expand in a cross-sectional direction upon incursion of a fluid pulsation to thereby increase an inner volume of the tube and correspondingly reduce fluid pressure therein. In a particular embodiment, the tube is fabricated from a gas-permeable and liquid-impermeable material for degassing transported fluids in the reduced-pressure chamber.
Abstract:
A flow-through vacuum degassing unit (10) for degassing a mobile phase in liquid chromatography applications includes a relatively flat self-supporting thin membrane (90) disposed in a compact degassing component, whereby the thin membrane is gas-permeable and liquid-impermeable to selectively degas a mobile phase. The self-supporting thin membrane is disposed on a permeable substrate (52) through which a vacuum is drawn by a connected vacuum source. In a particular embodiment, the self-supporting membrane (90) may be directly cast on the permeable substrate (52) through a solvent-free thermal process.
Abstract:
A flow-dampening degassing apparatus for transport of liquid chromatography fluids therethrough includes a substantially burdoin-shaped flexible tube disposed in a reduced-pressure chamber, the tube being sufficiently flexible to expand in a cross-sectional direction upon incursion of a fluid pulsation to thereby increase an inner volume of the tube and correspondingly reduce fluid pressure therein. In a particular embodiment, the tube is fabricated from a gas-permeable and liquid-impermeable material for degassing transported fluids in the reduced-pressure chamber.
Abstract:
An elongated flow-through degassing apparatus includes an elongated gas and liquid impermeable outer tube (512) and one or more gas-permeable, liquid-impermeable elongated inner tubes (514) extending within the outer tube (512) and at least partially through a chamber (518) defined within the outer tube (512). The apparatus also includes inlet (594) and outlet (596) connection structures operably coupled to respective portions of the outer tube (512) and the inner tubes (514) to further enable a sealed engagement between the outer tube (512) and the inner tubes (514), and to provide for connection devices to operably couple the degassing apparatus of the present invention to respective spaced apart components. The degassing apparatus is sufficiently flexible so as to be readily manipulatable into desired configurations.
Abstract:
A system (Fig 8) for conducting high-temperature liquid chromatographic analysis includes a mobile phase transport tube (202) configured to operably convey mobile phase from a source to respective chromatographic instruments (206) in the system, a pre-heater (212) apparatus operably coupled to the mobile phase transport tube for heating the mobile phase to a desired temperature, a chromatographic column (206) operably coupled to the pre-heater apparatus, and including temperature-maintaining means (204) for maintaining the column at a pre-determined temperature and a counter-flow heat exchanger (212) operably exchanging heat from outlet mobile phase to inlet mobile phase trough conductive heat transfer means. In a particular embodiment, the mobile phase passing through the chromatographic column is maintained in a substantially adiabatic environment.
Abstract:
A flow-through vacuum degassing unit (10) for degassing a mobile phase in liquid chromatography applications includes a relatively flat self-supporting thin membrane (90) disposed in a compact degassing component, whereby the thin membrane is gas-permeable and liquid-impermeable to selectively degas a mobile phase. The self-supporting thin membrane is disposed on a permeable substrate (52) through which a vacuum is drawn by a connected vacuum source. In a particular embodiment, the self-supporting membrane (90) may be directly cast on the permeable substrate (52) through a solvent-free thermal process.
Abstract:
A flow-through vacuum degassing unit for degassing a liquid includes a vacuum chamber adapted to be connected to a source for creating a vacuum in the chamber, an inlet and an outlet connection for admitting and discharging liquid to be degassed, a tube for conducting the liquid through the chamber, wherein the tube is a gas permeable polymeric resin material, and a control circuit for operating the source for creating a vacuum in the chamber responsive to a sensed vacuum level in the chamber.
Abstract:
A flow cell (10) for transporting fluid in a radiant energy field includes a cell body (12) having a tube (20) extending therethrough including a radiant energy blocking portion integral therewith. In a particular embodiment, the cell body (12) includes one or more end caps (14, 16) having a protrusion (40) may be inserted into the tube (20) to create a fluid seal, the end caps (14, 16) including open channels for transporting fluid (28, 32) and radiant energy (26, 30) therethrough, and the tube (20) in the cell body (12) includes an efficient radiant energy transmission lining that is spaced from the end cap protrusions (40), thereby forming a gap volume in the flow cell open channel (18), which gap volume may be calibrated such that radiant energy losses may be standardized in respective flow cells transporting fluids having various indices of refraction.