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公开(公告)号：EP4420713A2
公开(公告)日：2024-08-28
申请号：EP24172862.5
申请日：2021-01-21
发明人： MANTO, Kristen , ELFAR, John , GUDDADARANGAIAH, Jagadeeshaprasad Mashanipalya , GOVINDAPPA, Prem Kumar
IPC分类号： A61N1/00
CPC分类号： A61N1/36103 , A61N1/36146 , A61K9/0024 , A61K47/34 , A61K47/10
摘要： This document relates to methods and materials for treating nerve injuries. For example, thermoresponsive compositions containing 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP as well as methods for using such thermoresponsive compositions as a delivery system for 4-AP and/or one or more derivatives of 4-AP (e.g., to treat nerve injury) are provided. This document also provides methods and materials for treating a wound (e.g., a skin wound). For example, compositions containing 4-AP and/or one or more derivatives of 4-AP can be administered (e.g., systemically administered) to a mammal having a wound (e.g., a skin wound) to treat the wound (e.g., to promote wound healing).
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2.发明公开
公开(公告)号：EP4335511A3
公开(公告)日：2024-05-15
申请号：EP23206770.2
申请日：2012-04-30
发明人： EL-DEIRY, Wafik , ALLEN, Joshua E. , WU, Gen Sheng
IPC分类号： A61K31/519 , A61K31/337 , A61K39/395 , A61K31/437 , A61K31/4164 , A61P35/00 , A61K31/4188 , A61K31/4545 , A61K31/513
CPC分类号： A61K39/39558 , A61K31/337 , A61K31/4188 , A61K31/4545 , A61K31/513 , A61K31/519 , A61P35/00 , A61P43/00
摘要： A pharmaceutical composition, comprising the compound NSC350625, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, for use in a method of treating CNS cancer, lung cancer or lymphoma in a subject.
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公开(公告)号：EP4186555A1
公开(公告)日：2023-05-31
申请号：EP23152461.2
申请日：2012-01-05
发明人： Walters, Daniel A , Repka, William James , Powell, Kevin J. , Keenan, Richard L. , Walsh, Justin M. , Campbell, Robert L. , McBride, Mark W.
IPC分类号： A61M25/01 , F04C2/00 , A61M25/00 , A61M60/13 , A61M60/216 , A61M60/237 , A61M60/411 , A61M60/414 , A61M60/806 , A61M60/81 , A61M60/824 , A61M60/825 , A61M60/829 , A61M5/142 , A61M5/14 , F16C17/02 , F16C33/10 , F16C33/20
摘要： A heart pump and a catheter assembly therefor are provided that include a flexible catheter body having a proximal end and a distal end, the catheter body having a plurality of lumens therethrough. The catheter body can be sufficiently flexible to extend from a peripheral access to a patient's heart. The catheter assembly can also include an impeller assembly having an impeller and a housing. The impeller assembly can be coupled with the flexible catheter body such that a tensile force applied to opposite ends of the catheter assembly enhances the security of the connection between the catheter body and the impeller assembly.
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公开(公告)号：EP4157265A1
公开(公告)日：2023-04-05
申请号：EP21814416.0
申请日：2021-05-27
IPC分类号： A61K31/404 , A61K31/429 , A61K31/437
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公开(公告)号：EP4122631A1
公开(公告)日：2023-01-25
申请号：EP22182973.2
申请日：2022-07-05
摘要： Die Erfindung betrifft ein Verfahren zur Überwachung eines Brennschneidprozesses (10), welcher eine Vorheizphase (12), eine auf die Vorheizphase (12) folgende Lochstechphase (14) und eine auf die Lochstechphase (14) folgende Schneidphase (16) aufweist, wobei ein Schneidbrenner ein elektrisch leitendes Werkstück mit einer durch Verbrennung einer Gasmischung erzeugten Flamme beaufschlagt und wobei ein zwischen einem elektrisch leitenden Teil des Schneidbrenners und dem Werkstück fließender elektrischer Strom (I) mittels eines Strommessgeräts während eines Messzeitraums (18) gemessen wird. Erfindungsgemäß ist vorgesehen, dass ein Zündpunkt (20), an dem das Durchstechen eines Lochs durch das Werkstück mittels der Flamme durch Oxidation des Werkstücks beginnt, durch eine Änderung des gemessenen Stroms (I) detektiert wird.
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公开(公告)号：EP4066760A1
公开(公告)日：2022-10-05
申请号：EP22160318.6
申请日：2018-08-27
IPC分类号： A61B17/34 , A61B90/10 , A61B90/11 , A61B90/14 , A61B90/40 , A61B17/00 , A61B90/00 , A61B5/06 , A61B5/00 , A61B8/08 , A61B8/12 , A61B18/02 , A61B18/14 , A61B34/20 , A61B34/30 , A61B18/00 , A61B34/10
摘要： The present invention provides fixation devices, locking assemblies, and methods for using the same. The fixation devices of the invention are capable of accurate insertion of medical devices by providing detection means of a patient's internal anatomy and localizing a desired target. The devices are capable of locking into position to maintain accuracy.
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9.发明公开
公开(公告)号：EP4039812A1
公开(公告)日：2022-08-10
申请号：EP22156322.4
申请日：2018-02-28
发明人： CHEN, Gong
摘要： Methods of treating the effects of disruption of normal blood flow in the CNS in an individual subject in need thereof are provided according to aspects of the present invention which include administering a therapeutically effective dose of exogenous NeuroDl to an area where normal blood flow has been disrupted. Compositions are provided including 1) a recombinant adeno-associ-ated adenovirus expression vector comprising a glial cell specific promoter operably linked to a nucleic acid encoding a site-specific recombinase and 2) a recombinant adeno-associated adenovirus expression vector comprising a ubiquitous promoter operably linked to a nucleic acid encoding NeuroDl, wherein the nucleic acid encoding NeuroDl is inverted and flanked by two sets of site-specific recombinase recognition sites such that action of the recombinase irreversibly inverts the nucleic acid encoding NeuroDl such that NeuroDl is expressed in a mammalian cell.
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公开(公告)号：EP4001342A1
公开(公告)日：2022-05-25
申请号：EP22150946.6
申请日：2014-09-04
发明人： YANG, Jian , GUO, Jinshan
IPC分类号： C08G63/52 , A61L27/46 , A61L27/56 , C08G63/685 , C08G69/02
摘要： In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) citric acid, a citrate, or an ester of citric acid with (ii) a polyol, and (iii) a monomer comprising one or more alkyne moieties and/or azide moieties. The reaction product, in some instances, comprises a polymer. Further, in some cases, a composition described herein comprises a plurality of polymers. In some embodiments, the polymers are selected to be reactive with one another through a click chemistry reaction scheme to form a polymer network. In another aspect, medical implants and medical devices are described herein, the implants and devices comprising a polymer or polymer network described herein.
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