公开(公告)号：EP4420713A2

公开(公告)日：2024-08-28

申请号：EP24172862.5

申请日：2021-01-21

申请人： The Penn State Research Foundation

发明人： MANTO, Kristen ,  ELFAR, John ,  GUDDADARANGAIAH, Jagadeeshaprasad Mashanipalya ,  GOVINDAPPA, Prem Kumar

IPC分类号： A61N1/00

CPC分类号： A61N1/36103 ,  A61N1/36146 ,  A61K9/0024 ,  A61K47/34 ,  A61K47/10

摘要： This document relates to methods and materials for treating nerve injuries. For example, thermoresponsive compositions containing 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP as well as methods for using such thermoresponsive compositions as a delivery system for 4-AP and/or one or more derivatives of 4-AP (e.g., to treat nerve injury) are provided. This document also provides methods and materials for treating a wound (e.g., a skin wound). For example, compositions containing 4-AP and/or one or more derivatives of 4-AP can be administered (e.g., systemically administered) to a mammal having a wound (e.g., a skin wound) to treat the wound (e.g., to promote wound healing).

公开(公告)号：EP4093484A1

公开(公告)日：2022-11-30

申请号：EP21744391.0

申请日：2021-01-21

申请人： THE PENN STATE RESEARCH FOUNDATION

发明人： MANTO, Kristen ,  ELFAR, John ,  GUDDADARANGAIAH, Jagadeeshaprasad Mashanipalya ,  GOVINDAPPA, Prem Kumar

IPC分类号： A61N1/00

公开(公告)号：EP4420713A3

公开(公告)日：2024-10-30

申请号：EP24172862.5

申请日：2021-01-21

申请人： The Penn State Research Foundation

发明人： MANTO, Kristen ,  ELFAR, John ,  GUDDADARANGAIAH, Jagadeeshaprasad Mashanipalya ,  GOVINDAPPA, Prem Kumar

IPC分类号： A61N1/00 ,  A61K47/10 ,  A61K47/34 ,  A61K9/00 ,  A61N1/36

摘要： This document relates to methods and materials for treating nerve injuries. For example, thermoresponsive compositions containing 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP as well as methods for using such thermoresponsive compositions as a delivery system for 4-AP and/or one or more derivatives of 4-AP ( e.g., to treat nerve injury) are provided. This document also provides methods and materials for treating a wound ( e.g., a skin wound). For example, compositions containing 4-AP and/or one or more derivatives of 4-AP can be administered ( e.g. , systemically administered) to a mammal having a wound ( e.g., a skin wound) to treat the wound ( e.g., to promote wound healing).