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1.
公开(公告)号:EP3160508A4
公开(公告)日:2018-04-18
申请号:EP15815081
申请日:2015-06-30
发明人: MUCCIO DONALD D , ATIGADDA VENKATRAM REDDY , BROUILLETTE WAYNE J , GRUBBS CLINTON J , KIM JEONGA
IPC分类号: A61K45/06 , A61K31/203 , C07C57/40 , C07C57/42 , C07C57/60 , C07C57/62 , C07C59/56 , C07C63/331 , C07D307/54
CPC分类号: A61K45/06 , C07C57/40 , C07C57/42 , C07C57/60 , C07C57/62 , C07C59/56 , C07C63/331 , C07C2602/10 , C07D307/54
摘要: Novel rexinoid compounds are provided herein. Also provided herein are methods of using the compounds to treat disorders, such as metabolic disorders, diabetes, insulin resistance, glucose intolerance, obesity, steatosis, inflammation, and/or cancer.
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公开(公告)号:EP3169399A4
公开(公告)日:2018-03-14
申请号:EP15822567
申请日:2015-07-16
发明人: POPPLE RICHARD
IPC分类号: A61N5/01
CPC分类号: A61N5/1047 , A61N5/1039 , A61N5/1045 , A61N5/1081
摘要: In one embodiment, radiotherapy treatment is provided to a target volume of a patient by configuring a multileaf collimator of a radiation treatment machine in a first orientation so as to form an actual aperture having a first orientation, delivering radiation to the target volume through the actual aperture while in the first orientation with a single pass along an arcuate path centered on the target volume, configuring the multileaf collimator in a second orientation so as to place the actual aperture in a second orientation that is different from the first orientation, and delivering radiation to the target volume through the actual aperture while in the second orientation with a single pass back along the arcuate path such that a relatively large cumulative dose of radiation is delivered to the target volume through a virtual aperture created by an area of overlap between the first and second actual aperture orientations.
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公开(公告)号:EP3108556A4
公开(公告)日:2018-01-24
申请号:EP14882846
申请日:2014-02-21
CPC分类号: H02H3/165 , G01R31/024 , G01R31/027 , G01R31/06 , H02H3/04 , H02H3/162 , H02H3/253 , H02P29/024 , H02P29/0241
摘要: A method for detecting an open-phase condition of a transformer having a grounded-wye high voltage side connection including monitoring current flowing in a neutral connection on the high voltage side of the transformer in real time by voltage relaying and current relaying to identify an open phase condition signature in a signal capable of characterizing change of current magnitude. A current signal may be injected onto the neutral terminal and the zero-sequence mode of the transformer monitored to detect an open-phase condition indicated by an increase in network impedance and decrease or elimination of the injection current.
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