-
1.发明公开
公开(公告)号：EP4342900A1
公开(公告)日：2024-03-27
申请号：EP23806780.5
申请日：2023-05-10
发明人： YANG, Cheng , YANG, Guang , ZHOU, Honggang
IPC分类号： C07D493/10 , C07C57/15 , C07C51/41 , A61K31/365 , A61K39/395 , A61P35/00
摘要： The present invention relates to sesquiterpene derivatives represented by formula (I) or pharmaceutically acceptable salts thereof, a pharmaceutical composition comprising the sesquiterpene derivative and a PD-1 antibody as active components, and a preparation method therefor and the use thereof. The sesquiterpene derivatives or the pharmaceutically acceptable salts thereof of the present invention can remarkably enhance the response and treatment effects of a PD-1 antibody to tumors, and combined administration of the sesquiterpene derivatives or the pharmaceutically acceptable salts thereof and the PD-1 antibody presents an obvious synergistic effect and shows extremely strong anti-tumor activity. Therefore, the present invention provides a new way for clinical treatment of tumors and has potential clinical application value and great clinical application prospect.
-
2.发明公开
公开(公告)号：EP4116302A1
公开(公告)日：2023-01-11
申请号：EP21905192.7
申请日：2021-09-24
发明人： YANG, Cheng , YANG, Guang , ZHOU, Honggang , ZHANG, Liang , LI, Jian , LUN, Dongchao
IPC分类号： C07D487/04 , A61K31/519
摘要： The present disclosure relates to a pyrazolo[3,4-d]pyrimidine compound, a preparation method thereof, and use thereof in the preparation of an anti-tumor drug. This class of compound has an inhibitory effect on FGFR1-3 and exhibits an anti-proliferation effect on NCI-H1581 and SNU-16 cancer cell lines.
-
搜索结果
2 条记录 (耗时 0.011 秒)
