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公开(公告)号：EP4309783A1
公开(公告)日：2024-01-24
申请号：EP22382704.9
申请日：2022-07-22
发明人： Gómez-Avilés, Almudena , Rodríguez Solís, Rafael , García Frutos, Eva María , Bedia, Jorge , Belver, Carolina
摘要： The invention relates to novel Metal Organic Frameworks (MOFs) comprising a modified UiO-66-NH 2 , which consist of a N -cycloalkyl functionalized UiO-66-NH 2 . The invention also relates to the procedure to prepare them and the use thereof as a photocatalysts.
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2.发明公开
公开(公告)号：EP4309655A1
公开(公告)日：2024-01-24
申请号：EP22382706.4
申请日：2022-07-22
申请人： Consejo Superior de Investigaciones Científicas (CSIC) , Consorcio Centro de Investigación Biomédica en Red , Universidad Autónoma de Madrid , Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal
发明人： MARCO CONTELLES, José Luis , MURILLO CUESTA, Silvia , RODRÍGUEZ DE LA ROSA, Lourdes , VARELA NIETO, Isabel , ALCÁZAR GONZÁLEZ, Alberto
摘要： The present invention provides derivatives of quinolylnitrones of formula I, wherein the meaning of the substituents is as described in the description, useful in treatment and/or prevention of hearing loss.
Advantageously, these quinolylnitrones of formula (I) have a broad-spectrum effect, being efficient in the prevention and treatment of hearing loss regardless of its origin, whether caused by a physical agent, such as noise, or an ototoxic agent such as H 2 O 2 .-
公开(公告)号：EP4306170A2
公开(公告)日：2024-01-17
申请号：EP23193298.9
申请日：2020-02-19
申请人： Fundacion Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz , Universidad Autónoma De Madrid
发明人： GUADALAJARA LABAJO, Héctor , GARCIA ARRANZ, Mariano , GARCÍA OLMO, Damián , BARAMBIO BUENDÍA, Javier Jesús , CORTÉS GUIRAL, Delia , OLMEDILLAS LÓPEZ, Susana , VEGA CLEMENTE, Mª Luz
IPC分类号： A61P35/00
摘要： The present invention relates to a liquid collagenase solution which will generate the pre-conditioning of the tissues covering peritoneal tumors by means of washing with said solution for a predetermined time and at a predetermined concentration for use as cytotoxic drug-enhancing or adjuvant treatment in the treatment of solid peritoneal tumors. Throughout the present invention, said solution will be used for administration to or for irrigating the tumor directly at a concentration and for a time such that it causes thinning of the mesothelial layer covering the intestinal tract without the involvement of intermediate or internal layers.
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公开(公告)号：EP4180121A1
公开(公告)日：2023-05-17
申请号：EP21383033.4
申请日：2021-11-15
摘要： The present invention refers to a specific composition, which functions as an enzyme mimic or artificial enzyme, for assessing the presence of microorganisms in a test sample. On the other hand, the composition can be used as a medicament, preferably in the treatment of infections caused by said microorganisms.
The composition comprises:
a) a coordination polymer which in turn comprises a polymeric crystalline structure with a repeating core characterized by Formula I: M2L2(H20)4 wherein:
i. M is copper (II) metal ion,
ii. L is an aromatic pseudo-peptide characterized by Formula II: H2I-bis-amino acid or Formula III: H2T-bis-amino acid, wherein T is terephthaloyl, I is isophthaloyl, and the amino acid is a L or D amino acid; and
b) H2O2.-
公开(公告)号：EP4116434A1
公开(公告)日：2023-01-11
申请号：EP21382615.9
申请日：2021-07-07
发明人： GONZÁLEZ VASCONCELLOS, Iria María , COBOS FERNÁNDEZ, María de los Ángeles , FERNÁNDEZ PIQUERAS, José , SANTOS HERNANDEZ, Javier
IPC分类号： C12Q1/6841
摘要： The present invention refers to an in vitro method for quantifying total cell RNA content, preferably total cell content of long-non-coding RNAs (IncRNA), more preferably total cell content of IncRNA molecules transcribed from telomeric or sub-telomeric sequences or present in telomeric regions, such as TERRA and/or TERC, using a labelled probe and flow cytometry.
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公开(公告)号：EP3851117A1
公开(公告)日：2021-07-21
申请号：EP20382026.1
申请日：2020-01-20
发明人： GARCÍA DEL PORTILLO, Francisco , CASTANHEIRA, Sónia , CESTERO CARRILLO, Juan José , LÓPEZ ESCARPA, David , PUCCIARELLI MORRONE, María Graciela
摘要： The invention relates to an in vitro screening method to identify inhibitors of intracellular bacterial growth and persistence and uses thereof as medicament, preferably as antibiotics. Furthermore, the present invention also relates to the inhibitors for use in the treatment and/or prevention of intracellular bacterial infections.
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公开(公告)号：EP3669893A1
公开(公告)日：2020-06-24
申请号：EP18382956.3
申请日：2018-12-20
IPC分类号： A61K45/06 , A61K35/768 , A61P35/00
摘要： Treatment of cancer harboring mutations in the TP53 gene and/or post-translational modifications in the p53 protein. The present invention relates to the use of viruses belonging to the family Parvoviridae , genus Protoparvovirus , or combinations of such viruses with chemotherapy drugs, in the treatment of cancer. In particular the cancer is characterized by showing mutations in the TP53 gene and/or post-translational modifications in the p53 protein.
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公开(公告)号：EP3656762A1
公开(公告)日：2020-05-27
申请号：EP18382856.5
申请日：2018-11-26
发明人： FERNÁNDEZ MEDARDE, Antonio , VINUESA NAVARRO, María de los Ángeles , SÁNCHEZ LÓPEZ, José María , CAÑEDO HERNÁNDEZ, Librada María , FRESNO ESCUDERO, Manuel , SÁNCHEZ -VALDEPEÑAS VILLEGAS, Carmen María
IPC分类号： C07D209/52 , A61K31/403 , A61P29/00
摘要： The invention relates to a family of fungal compounds which are inhibitors of NF-κB inducing kinase and are thus useful in the treatment of NF-κB-related diseases or disorders such as inflammatory or autoimmune diseases or disorders.
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公开(公告)号：EP3178485B1
公开(公告)日：2018-12-12
申请号：EP15738128.6
申请日：2015-05-27
申请人： Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca , Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz , Universidad Autónoma de Madrid
发明人： EGIDO DE LOS RÍOS, Jesús , GÓMEZ GUERRERO, Carmen , SIMÓ CANONGE, Rafael , HERNÁNDEZ PASCUAL, Cristina
CPC分类号： A61K38/1709 , A61K9/0048 , A61K38/10 , A61K47/542
摘要： The present invention relates to a SOCS1-derived peptide for use in chronic complications of diabetes, particularly ocular, renal, nerve and vascular complications, as well as compositions containing same and isolated polynucleotides encoding same. The present invention also relates to the SOCS1-derived peptide for topical use in the treatment and/or prevention of neurodegenerative diseases of the retina, particularly in the early stages of diabetic retinopathy and other diseases of the retina in which neurodegeneration plays an essential role.
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10.发明公开
公开(公告)号：EP3342857A1
公开(公告)日：2018-07-04
申请号：EP18152520.5
申请日：2005-10-04
发明人： GARCÍA CASTRO, Rosa Ana , FERNÁNDEZ MIGUEL, María Gema , GARCÍA ARRANZ, Mariano , GONZÁLEZ DE LA PEÑA, Manuel Angel , GARCÍA OLMO, Damián
CPC分类号： A61K35/28 , C12N5/0607 , C12N5/0619 , C12N5/0654 , C12N5/0658 , C12N5/0667 , C12N2506/1384 , C12N2510/00 , G01N33/5008
摘要： Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. This invention relates to the identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. Specifically, it relates to an adult multipotent cell or a cell population or composition comprising said cell, isolated from non-osteochondral mesenchymal tissue, characterized in that it is positive for the following markers: CD9, CD10, CD13, CD29, CD44, CD49A, CD51, CD54, CD55, CD58, CD59, CD90 and CD105 and because it lacks expression of the following markers: CD11b, CD14, CD15, CD16, CD31, CD34, CD45, CD49f, CD102, CD104, CD106 and CD133.
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