公开(公告)号：EP2094631B1

公开(公告)日：2015-09-16

申请号：EP07871812.9

申请日：2007-12-07

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Université Louis Pasteur, U.L.P.

发明人： IVANOVA, Svetlana ,  VANHAECKE, Estelle ,  LIBS, Suzanne ,  LOUIS, Benoit ,  PHAM-HUU, Cuong ,  LEDOUX, Marc

IPC分类号： C07C41/09 ,  C07C43/04

CPC分类号： C07C41/09 ,  C07C43/043

公开(公告)号：EP1948633B1

公开(公告)日：2011-08-10

申请号：EP06842347.4

申请日：2006-10-11

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Université Louis Pasteur Strasbourg I

发明人： MELY, Yves ,  KLYMCHENKO, Andrey ,  DEMCHENKO, Oleksandr ,  SHYNKAR, Vasyl

IPC分类号： C07D311/30 ,  C07D409/04 ,  A61B5/00

CPC分类号： C07D311/30 ,  C07D409/04

摘要： The present invention relates a compound of formula (I) wherein: - R1 represents a linear alkyl group of 4 to 20 carbon atoms; - Y represents a linear alkyl group of 1 to 5 carbon atoms or a group of formula -R-O-R'-, -R-CO-R'- or -R-CO-NH-R'-, in which R represents a linear alkyl group of 1 to 3 carbon atoms, R' represents a linear alkylene group of 0-3 carbon atoms, Y being linked to the bicycle in position 6 or 7; - Z represents a linear alkyl chain of 3 or 4 carbon atoms; - A represents an oxygen atom, a sulphur atom, or a -NH group, or an amminoalkyl group -NR'' in which R' represents an alkyl group of 1 to 20 carbon atoms; - Ar represents an aromatic cycle or polycycle consisting of 6 to 14 carbon atoms, or an aromatic heterocycle, said heterocycle containing 4, 5 or 6 carbon atoms and at least one heteroatom selected in the group consisting of N, S, and O, or a condensed aromatic heterobicycle, said heterobicycle consisting of 6 to 9 carbon atoms and at least one heteroatom selected in the group consisting of N, S, and O ; - R2 and R3, which are identical or different, each representing a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R2 and R3 optionally forming a 5- to 7-membered ring with the nitrogen atom; - R4, R5 and R6, identical or different, represent an hydrogen, a linear alkyl group or a linear oxyalkyl group of 1 to 4 carbon atoms.

公开(公告)号：EP1611170B1

公开(公告)日：2011-07-06

申请号：EP04742489.0

申请日：2004-04-13

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Université Louis Pasteur

发明人： MIOSKOWSKI, Charles ,  RICKLING, Stéphane ,  SCHULTZ, Patrick

IPC分类号： C08F38/00

CPC分类号： B82Y30/00 ,  A61K9/0092 ,  A61K9/1274 ,  A61K47/34 ,  B82Y40/00 ,  C01B32/17 ,  C01B2202/02 ,  C01B2202/06 ,  C01B2202/30 ,  C08F292/00 ,  Y10S977/756 ,  Y10T428/2991 ,  Y10T428/2998

摘要： The invention relates to macromolecules auto-assembled and photopolymerised around carbon nanotubes. Said macromolecules are essentially formed from rings of lipid compounds, polymerised about the nanotubes, said polymerised compounds being obtained from lipid molecules with one or two chains A, bonded to a group Z where A is a chain, CH3-(CH2)m-C C-C C-(CH2)n-, where n and m, independently = whole numbers from 1 to 16 and Z is a polar head group embodied by a -COOH, -CO-NH-Y, -NH2 or N+(R)3, where R is an alkyl with C1 to C4 and Y is a -(CH2)4-C(R1)-N(CH2-COOH)2 group with R= H, or a COOH group, where A is a single lipid chain or a group of structure (I) or (II), where R2 = a COOH, or -CO-NH-Y1 group with Y1 = a -(CH2)4-C(R3)-N(CH2COOH)2 group with R3 = H or a COOH group, where Z and R2 can also be neutral polar head groups of the sugar or polysaccharide type. The above is of application particularly to the protection and purification of nanotubes, as a hydrophobic molecule or membrane protein vector or as a molecular motor.

公开(公告)号：EP2264014A1

公开(公告)日：2010-12-22

申请号：EP10181297.2

申请日：2002-09-03

申请人： Université Louis Pasteur ,  Centre National de la Recherche Scientifique

发明人： Watterson, Daniel M. ,  Van Eldik, Linda J. ,  Velentza, Anastasia ,  Zasadzki, Magdalena ,  Sawkar, Ann R. ,  Lukas, Thommas J. ,  Mizoeva, Salida ,  Haiech, Jacques ,  Hibert, M ,  Bourgignon, Jean-Jacques

IPC分类号： C07D237/06 ,  C07D237/30 ,  A61K31/501 ,  A61P11/00 ,  A61P35/00 ,  C07D237/20 ,  C07D237/26 ,  C07D403/12 ,  C07D401/12

CPC分类号： C07D401/12 ,  A61K31/501 ,  C07D237/20 ,  C07D237/26 ,  C07D403/12 ,  C07D487/04

摘要： This invention relates to a novel class of pyridazine compounds and related methods of use.

摘要翻译： 本发明涉及一类新颖的哒嗪化合物及其相关使用方法。

公开(公告)号：EP2240120A2

公开(公告)日：2010-10-20

申请号：EP08872036.2

申请日：2008-12-02

申请人： PROTIP SAS ,  Hôpitaux Universitaires de Strasbourg ,  Université Louis Pasteur

发明人： DEBRY, Christian ,  WALDER, André ,  DUFFAIT, Roland ,  LEFEBRE, Sylvain ,  BLANC, Claudia

IPC分类号： A61F2/20 ,  A61M16/04 ,  A61L27/14

CPC分类号： A61F2/203 ,  A61M16/0468

摘要： The present invention relates to a valve device (1) designed to be implanted in a dysfunctional larynx or in a prosthetic larynx, said device comprising a distal portion forming an annular support structure (3, 3', 3'') and a central portion forming an obturator (5, 5'), characterized in that said obturator (5, 5') comprises i) a peripheral part forming a first valve (7, 7', 7'') integral with the annular support structure (3, 3', 3'') in a first hinge region (2, 2''), and ii) a central part forming a second valve (9, 9', 9'') integral with the first valve in a second hinge region (4, 4'').

公开(公告)号：EP2189453A1

公开(公告)日：2010-05-26

申请号：EP08305835.4

申请日：2008-11-25

申请人： Université Louis Pasteur

发明人： DESAUBRY, Laurent ,  DESAUBRY, Gunsel Canan ,  CRESTEIL, Thierry ,  TÜRKERI, Gülen

IPC分类号： C07D307/93 ,  A61K31/343 ,  A61P9/00

CPC分类号： C07D307/93

摘要： The present invention discloses new rocaglaol derivatives and the use of rocaglaol derivatives to prevent or to limit the cardiotoxicity of an antineoplastic agent, in particular to prevent or to limit the apoptosis of cardiomyocytes induced by such agent.

摘要翻译： 本发明公开了新的罗卡洛尔衍生物和罗卡洛尔衍生物用于预防或限制抗肿瘤药物的心脏毒性的用途，特别是防止或限制由这种药剂引起的心肌细胞凋亡。

公开(公告)号：EP2177496A1

公开(公告)日：2010-04-21

申请号：EP08305646.5

申请日：2008-10-07

申请人： Assistance Publique - Hôpitaux de Paris ,  Centre National de la Recherche Scientifique ,  UNIVERSITE PIERRE ET MARIE CURIE ,  Université Louis Pasteur

发明人： Choppin, Sabine ,  Colobert, Françoise ,  Hanquet, Gilles ,  Leroux, Frédéric ,  Mahmoudi, Nassira ,  Mazier, Dominique

IPC分类号： C07C41/01 ,  C07C43/23

CPC分类号： C07C43/23 ,  C07B2200/07 ,  C07C41/26 ,  C07D317/54

摘要： The present invention discloses new analogs of polysphorin and their uses as antimalarial drugs which are highly effective in the hepatic phase of the disease. The present invention further discloses a new method for preparing these compounds.

摘要翻译： 本发明公开了多卟啉的新类似物及其作为抗疟药物的用途，其在该疾病的肝脏阶段是非常有效的。 本发明还公开了一种制备这些化合物的新方法。

公开(公告)号：EP1347950B1

公开(公告)日：2010-02-17

申请号：EP01997471.6

申请日：2001-11-16

申请人： Université Louis Pasteur (Etablissement Public à Caractère Scientifique, Culturel et Professionnel)

发明人： BOURGUIGNON, Jean-Jacques ,  MAITRE, Michel ,  KLOTZ, Evelyne ,  SCHMITT, Martine ,  GOBAILLE, Serge ,  MACHER, Jean-Paul

IPC分类号： C07C59/48

CPC分类号： C07D215/227 ,  C07C59/48 ,  C07C59/56 ,  C07C59/64 ,  C07C229/42 ,  C07C233/54 ,  C07C259/06 ,  C07D207/34 ,  C07D207/48 ,  C07D209/08 ,  C07D209/18 ,  C07D209/34 ,  C07D209/42 ,  C07D209/86 ,  C07D213/55 ,  C07D215/233 ,  C07D223/22 ,  C07D241/42 ,  C07D307/33 ,  C07D307/58 ,  C07D307/79 ,  C07D307/91 ,  C07D319/06 ,  C07D319/18 ,  C07D327/08 ,  C07D333/24 ,  C07D333/60 ,  C07D333/76 ,  C07D405/04 ,  C07D471/04 ,  C07D487/04

公开(公告)号：EP1317479B1

公开(公告)日：2009-09-02

申请号：EP01970656.3

申请日：2001-09-06

申请人： Aventis Pharma S.A. ,  Université Louis Pasteur de Strasbourg

发明人： NICOLAU, Yves, Claude

IPC分类号： C07K14/00 ,  C07K16/00 ,  A61P25/28

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/55555 ,  C07K14/4711 ,  C07K14/4713 ,  C07K14/79 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention generally relates to the detection, treatment or prevention of disease states. Specifically, the present invention relates to the detection, treatment or prevention of amyloidosis or amyloid-associated diseases. The present invention further comprises methods and compositions comprising therapeutic vaccines, antisera and molecular constructs, comprising expression vectors and fusion proteins encoded therein.

公开(公告)号：EP2084125A1

公开(公告)日：2009-08-05

申请号：EP07866480.2

申请日：2007-10-31

申请人： Universite De Haute Alsace ,  Université Louis Pasteur ,  Centre National de la Recherche Scientifique (CNRS)

发明人： TARNUS-RONDEAU, Céline ,  DEFOIN, Albert ,  ALBRECHT, Sébastien ,  MAIEREANU, Anamaria ,  FAUX, Nadège ,  PALE, Patrick

IPC分类号： C07C225/22 ,  C07C323/30 ,  A61K31/135 ,  A61P35/00

CPC分类号： C07C225/20 ,  C07C319/14 ,  C07C319/20 ,  C07C323/30 ,  C07C2602/12 ,  C07C2603/34

摘要： The invention relates to a compound of the general formula (I) : F(I) in which: R1, R2, R3, R4, R5, R6, R9, R10, R11 further represent a (C1-C6) alkoxy, (C1-C6) aralkyloxy, (C1-C6) alkylthio, (Q1- C6) aralkylthio radical; R9 et R11 can also form together a carbonated cycle or heterocycle or can form a double bond with the two carbon atoms adjacent to the heptene cycle; R1 et R2 can form together a carbonated cycle or heterocycle; or R1 can be bonded to the heptene cycle by a double bond while R2 is absent; R3, R4, R5 and R6 further represent a polyfluoro (C1-C6) alkyl, (C1-C6) alkoxy radical, an aryl or heteroaryl group; R3 and R4, R4 and R5, R5 and R6 can further form together a methylenedioxy radical joining the adjacent carbon atoms or an aromatic carbonated cycle or an aromatic heterocycle; R7 is a hydrogen atom, a (C1-C6) alkyl radical; X is an oxygen or sulphur atom, N-R12, N-O-R13, in which R12 and R13 represent a hydrogen atom, a (C1-C6) alkyl, (C1- C6) (cycloalkyl) alkyl, (C1-C6) (heterocycloalkyl) alkyl, (C1-C6) aralkyl, (Ci-C6) heteroaralkyl radical; Y is a carbon atom; a nitrogen atom R8 or R9 being then absent; the invention also relates to addition salts with acids except the compound for which R4, R5, R6 represent a methoxy radical, R1, R2, R3, R7 to R11 represent a hydrogen atom, X represents an oxygen atom and Y represents a carbon atom.