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    NOVEL ELATONIN LIGANDS HAVING ANTIDEPRESSANT ACTIVITY AS WELL AS SLEEP INDUCING PROPERTIES
    3.
    发明公开
    NOVEL ELATONIN LIGANDS HAVING ANTIDEPRESSANT ACTIVITY AS WELL AS SLEEP INDUCING PROPERTIES 有权
    新Elatoninliganden具有抗抑郁活性和睡眠功能

    公开(公告)号：EP1973868A1

    公开(公告)日：2008-10-01

    申请号：EP07701686.3

    申请日：2007-01-12

    申请人： McGill University ,  Universita Degli Studi Di Parma ,  UNIVERSITA' DEGLI STUDI DI MILANO ,  Universita Degli Studi Di Urbino

    发明人： GOBBI, Gabriella ,  MOR, Marco ,  RIVARA, Silvia ,  FRASCHINI, Franco ,  TARZIA, Giorgio ,  BEDINI, Annalida ,  SPADONI, Gilberto ,  LUCINI, Valeria

    IPC分类号： C07C237/04 ,  A61P25/00 ,  A61P25/24

    CPC分类号： C07C233/43 ,  C07C233/36

    摘要： Novel melatonin ligands of Formula (I) or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR8;Y is selected from the group consisting of hydrogen, aryl, heteroaryl, CrC6 alkyl, C3-C6 cycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, -OCF3, CF3, C1-C8 alkyl, C1C8 alkyloxy, C1C8 alkylthio, halogen and -Z-(CH2)P-A; R1 is selected from the group consisting of C1C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy-substituted C1C4 alkyl, hydroxy-substituted C3-C6 cycloalkyl, and NHR5, wherein R5 is C1C3 alkyl or C3-C6 cycloalkyl; R2 is selected from the group consisting of: hydrogen, C1C4 alkyl, C1C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R3 is selected from the group consisting of hydrogen, C1C4 alkyl, C1C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R and R3 may be connected together to form an -0-(CH2)v bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; R4 is selected from the group consisting of hydrogen, C1C4 alkyl, C1C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R6 is selected from the group consisting of hydrogen and C1C6 alkyl; R7 is selected from the group consisting of hydrogen, C1C4 alkyl, C1C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; and R8 is selected from the group consisting of hydrogen and C1C4 alkyl.

    A CROP ROTATION AND SCHEDULING METHOD IN A SUSTAINABLE AGRICULTURE SCENARIO
    5.
    发明公开
    A CROP ROTATION AND SCHEDULING METHOD IN A SUSTAINABLE AGRICULTURE SCENARIO 审中-公开

    公开(公告)号：EP4459523A1

    公开(公告)日：2024-11-06

    申请号：EP24173966.3

    申请日：2024-05-02

    申请人： Universita' Degli Studi di Siena ,  Universita' Degli Studi Della Tuscia

    发明人： DETTI, Paolo ,  BLASI, Emanuele ,  BENINI, Marco ,  FOSCI, Lorenzo

    IPC分类号： G06Q10/04 ,  A01B79/00 ,  G06Q50/02

    摘要： A method for planning crop rotations in at least one plot (h i , i=1...n) of land within a predetermined planning horizon or time (T), to implement a cropping method, includes the steps of: for said or each plot (h), determination of a set (C) of acceptable crops (c) based on the soil nature of the plot(s) (h), an availability of irrigation, exposure, and geographic coordinates; for said or each plot (h), definition of a succession of planting periods (t) until the planning horizon (T) is completed; specification of a plurality of desired crops (c i ) among the acceptable crops; choice of a σ sequence of k crops, where k≥2, among the desired crops (c i , i=1...k); definition of a plurality of eligible sequences σ of the desired crops c i to be assigned to plot h, according to respective predetermined time orders, subject to agronomic constraints including on each plot, uniqueness of the crop c to be assigned in each planting period t, and minimum and maximum area assigned to each crop c in each planting period t; determination, for each of the eligible sequences σ, and for all p sowing periods t of planning time T, of a total yield π h for said or each plot h, obtained as the sum of seasonal yields Y h in sowing periods t, in which each of the seasonal yields in a sowing period t is calculated based on a maximum number of crops k comprising the assigned crop in sowing period t, and the k-1 assigned crops, according to each of the sequences, in a corresponding k-1 number of consecutively preceding earlier sowing periods preceding said sowing period (Figure 1).