-
公开(公告)号：EP4061831A1
公开(公告)日：2022-09-28
申请号：EP20825064.7
申请日：2020-11-23
申请人： Research Institute at Nationwide Children's Hospital , Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico , Universita' degli Studi di Milano
发明人： MEYER, Kathrin, Christine , LIKHITE, Shibi , FOUST, Kevin , KASPAR, Brian, K. , NIZZARDO, Monica , CORTI, Stefania, Paola
IPC分类号： C07K14/435 , C12N15/87
-
公开(公告)号：EP3907301A1
公开(公告)日：2021-11-10
申请号：EP20173612.1
申请日：2020-05-08
IPC分类号： C12Q1/6886
摘要： The present invention relates to methods and kits for the evaluation of risk and treatment of distant recurrence of breast cancer in a subject. The methods and kits can comprise combining the measured expression levels of a subset of genes selected from a 20-gene signature with tumor size and nodal status to determine the risk of distant recurrence.
-
公开(公告)号：EP3796956A1
公开(公告)日：2021-03-31
申请号：EP19732738.0
申请日：2019-05-23
-
公开(公告)号：EP3620452A1
公开(公告)日：2020-03-11
申请号：EP18193196.5
申请日：2018-09-07
IPC分类号： C07D215/233
摘要： The present invention relates to a process for the preparation of Lenvatinib of formula (I) from 4-amino-3-chloro-phenol and 4-chloro-7-methoxyquinoline-6-carboxamide.
-
公开(公告)号：EP3608342A1
公开(公告)日：2020-02-12
申请号：EP19000360.8
申请日：2019-08-02
摘要： A method is proposed for producing cellulose nanocrystals (CNCs) comprising:
i. a step of feeding a cellulosic raw material, such as native vegetable fibres or vegetable biomass materials or by-products of the textile, milling industries, and of paper,
ii. a step of putting the cellulosic raw material in contact with an oxidative acid component at high temperature to produce cellulose nanocrystals (CNCs) and
iii. a step of recovery of the cellulose nanocrystals obtained,
in which method there is provided a hydrolytic-oxidative microwave-assisted treatment, with closed microwave reactor under pressurised conditions.
The nanocrystals obtained can advantageously form pourable suspensions, for example as a thin and functional cladding on the activated surface of flexible packaging materials.-
6.发明公开
公开(公告)号：EP3539118A1
公开(公告)日：2019-09-18
申请号：EP17805282.5
申请日：2017-11-14
发明人： FIORE, Gianfranco Beniamino , REDAELLI, Alberto Cesare Luigi , VISMARA, Riccardo , ANTONA, Carlo , GELPI, Guido , LEMMA, Massimo Giovanni , MANGINI, Andrea
摘要： A test bench assembly for simulating cardiac surgery includes a passive heart having at least one pair of cardiac chambers with an atrial chamber and a ventricular chamber. A reservoir is adapted to house working fluid. A pressure generator fluidically connects both to the ventricular chamber of the passive heart and to the reservoir. A pressure regulation device provides working fluid in input to the atrial chamber with preload pressure, and working fluid in output from the ventricular chamber with afterload pressure. The pressure regulation device fluidically connects both to the atrial chamber of the passive heart and to the ventricular chamber of the passive heart. The pressure regulation device has a single compliant element for each pair of cardiac chambers, which provides working fluid with both preload, and afterload pressures.
-
公开(公告)号：EP3525586A1
公开(公告)日：2019-08-21
申请号：EP17788311.3
申请日：2017-10-11
-
公开(公告)号：EP3233840B1
公开(公告)日：2018-11-21
申请号：EP15830780.1
申请日：2015-12-14
IPC分类号： C07D405/12 , A61K31/416 , C07D231/56 , A61P35/00 , A61P25/28 , A61P25/16 , A61P29/00
CPC分类号： C07D231/56 , A61P25/28 , A61P29/00 , A61P35/00 , C07D261/20 , C07D405/12
摘要： The present invention relates to novel heterocyclic derivatives having general formula (I) and their therapeutic use for diseases such as cancer, inflammation, pain, autoimmune diseases or neurodegenerative diseases like Alzheimer's or Parkinson's disease that can be treated by modulation of certain protein kinases. Compounds of formula (I) can be used for treatment of patients who do not respond to kinase inhibition therapy that comprises currently available medications.
-
公开(公告)号：EP2874663B1
公开(公告)日：2018-01-10
申请号：EP13773359.8
申请日：2013-07-19
发明人： GRANUCCI, Francesca , PROSPERI, Davide , ZANONI, Ivan , CORSI, Fabio, Ruggero, Maria , COLOMBO, Miriam
CPC分类号： A61K9/5138 , A61K9/5115 , A61K38/1709 , A61K47/6935 , A61K49/1851 , C07K14/47
摘要： The present invention relates to methods and means of transport of active substances in the cell cytosol. In particular, the invention relates to means that make it possible to transport directly in the cytosol substances capable of interacting with protein systems, such as the family of nuclear factors of activated T-cells (NFATs) or nucleic acids localized in the cytosol. In particular, the invention relates to nanoconstructs useful in the treatment of inflammatory diseases, methods for their preparation, and compositions containing them.
-
10.发明公开
公开(公告)号：EP3233840A1
公开(公告)日：2017-10-25
申请号：EP15830780.1
申请日：2015-12-14
IPC分类号： C07D405/12 , A61K31/416 , C07D231/56 , A61P35/00 , A61P25/28 , A61P25/16 , A61P29/00
CPC分类号： C07D231/56 , A61P25/28 , A61P29/00 , A61P35/00 , C07D261/20 , C07D405/12
摘要： The present invention relates to novel heterocyclic derivatives having general formula (I) and their therapeutic use for diseases such as cancer, inflammation, pain, autoimmune diseases or neurodegenerative diseases like Alzheimer's or Parkinson's disease that can be treated by modulation of certain protein kinases. Compounds of formula (I) can be used for treatment of patients who do not respond to kinase inhibition therapy that comprises currently available medications.
摘要翻译： 本发明涉及具有通式（I）的新型杂环衍生物及其对诸如癌症，炎症，疼痛，自身免疫疾病或可通过调节某些蛋白激酶来治疗的阿尔茨海默病或帕金森病等神经退行性疾病的疾病的治疗用途。 式（I）化合物可用于治疗对包含现有药物的激酶抑制疗法无应答的患者。
-
-
-
-
-
-
-
-
-
搜索结果
166 条记录 (耗时 0.026 秒)
